SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fv5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)
2fv5 ADAM 17
(Homo
sapiens)
4 / 5 HIS A 405
GLU A 406
HIS A 409
HIS A 415
ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
0.28A 1os2A-2fv5A:
9.5
1os2A-2fv5A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)
2fv5 ADAM 17
(Homo
sapiens)
4 / 4 HIS A 405
GLU A 406
HIS A 409
HIS A 415
ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
0.25A 1os2D-2fv5A:
9.6
1os2D-2fv5A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)
2fv5 ADAM 17
(Homo
sapiens)
5 / 10 THR A 347
HIS A 405
GLU A 406
HIS A 409
ALA A 439
541  A   1 (-3.6A)
ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
541  A   1 (-3.9A)
1.04A 1r55A-2fv5A:
21.3
1r55A-2fv5A:
27.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)
2fv5 ADAM 17
(Homo
sapiens)
5 / 10 THR A 347
HIS A 405
GLU A 406
HIS A 409
HIS A 415
541  A   1 (-3.6A)
ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
0.28A 1r55A-2fv5A:
21.3
1r55A-2fv5A:
27.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)
2fv5 ADAM 17
(Homo
sapiens)
4 / 4 HIS A 405
GLU A 406
HIS A 409
HIS A 415
ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
0.28A 1uttA-2fv5A:
10.0
1uttA-2fv5A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)
2fv5 ADAM 17
(Homo
sapiens)
4 / 4 HIS A 405
GLU A 406
HIS A 409
HIS A 415
ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
0.29A 1utzA-2fv5A:
9.8
1utzA-2fv5A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)
2fv5 ADAM 17
(Homo
sapiens)
4 / 4 HIS A 405
GLU A 406
HIS A 409
HIS A 415
ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
0.28A 1utzB-2fv5A:
9.8
1utzB-2fv5A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)
2fv5 ADAM 17
(Homo
sapiens)
4 / 6 HIS A 405
GLU A 406
HIS A 409
HIS A 415
ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
0.26A 1y93A-2fv5A:
9.8
1y93A-2fv5A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)
2fv5 ADAM 17
(Homo
sapiens)
4 / 4 HIS A 405
GLU A 406
HIS A 409
HIS A 415
ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
0.22A 2hu6A-2fv5A:
9.9
2hu6A-2fv5A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)
2fv5 ADAM 17
(Homo
sapiens)
5 / 9 LEU A 348
HIS A 405
GLU A 406
HIS A 409
HIS A 415
541  A   1 (-4.4A)
ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
0.29A 2jihA-2fv5A:
20.4
2jihA-2fv5A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)
2fv5 ADAM 17
(Homo
sapiens)
5 / 8 LEU A 348
HIS A 405
GLU A 406
HIS A 409
HIS A 415
541  A   1 (-4.4A)
ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
0.23A 2jihB-2fv5A:
20.6
2jihB-2fv5A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)
2fv5 ADAM 17
(Homo
sapiens)
4 / 6 HIS A 405
GLU A 406
HIS A 409
HIS A 415
ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
0.33A 2ow9A-2fv5A:
9.6
2ow9A-2fv5A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)
2fv5 ADAM 17
(Homo
sapiens)
4 / 4 HIS A 405
GLU A 406
HIS A 409
HIS A 415
ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
0.32A 2ow9B-2fv5A:
9.5
2ow9B-2fv5A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)
2fv5 ADAM 17
(Homo
sapiens)
4 / 4 HIS A 405
GLU A 406
HIS A 409
HIS A 415
ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
0.34A 2ozrC-2fv5A:
9.2
2ozrC-2fv5A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)
2fv5 ADAM 17
(Homo
sapiens)
4 / 4 HIS A 405
GLU A 406
HIS A 409
HIS A 415
ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
0.31A 2ozrD-2fv5A:
9.3
2ozrD-2fv5A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)
2fv5 ADAM 17
(Homo
sapiens)
4 / 4 HIS A 405
GLU A 406
HIS A 409
HIS A 415
ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
0.31A 2ozrE-2fv5A:
9.4
2ozrE-2fv5A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)
2fv5 ADAM 17
(Homo
sapiens)
3 / 3 HIS A 405
HIS A 409
HIS A 415
ZN  A   3 ( 3.2A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
0.23A 2ozrF-2fv5A:
9.4
2ozrF-2fv5A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)
2fv5 ADAM 17
(Homo
sapiens)
5 / 12 VAL A 258
THR A 387
ALA A 399
ASP A 400
ARG A 257
None
1.32A 2qm9A-2fv5A:
undetectable
2qm9A-2fv5A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XNR_A_ACTA1001_0
(NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
3)
2fv5 ADAM 17
(Homo
sapiens)
3 / 3 SER A 474
ARG A 473
GLN A 278
None
0.80A 2xnrA-2fv5A:
undetectable
2xnrA-2fv5A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)
2fv5 ADAM 17
(Homo
sapiens)
5 / 11 THR A 403
LEU A 227
ASN A 410
LEU A 251
ILE A 279
None
1.22A 3a50B-2fv5A:
undetectable
3a50B-2fv5A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)
2fv5 ADAM 17
(Homo
sapiens)
5 / 11 THR A 403
LEU A 227
ASN A 410
LEU A 251
ILE A 279
None
1.20A 3a50C-2fv5A:
undetectable
3a50C-2fv5A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)
2fv5 ADAM 17
(Homo
sapiens)
6 / 9 LEU A 348
HIS A 405
GLU A 406
HIS A 409
HIS A 415
ILE A 438
541  A   1 (-4.4A)
ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
None
0.43A 3hy7A-2fv5A:
20.0
3hy7A-2fv5A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)
2fv5 ADAM 17
(Homo
sapiens)
6 / 9 LEU A 348
HIS A 405
GLU A 406
HIS A 409
HIS A 415
ILE A 438
541  A   1 (-4.4A)
ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
None
0.37A 3hy7B-2fv5A:
20.0
3hy7B-2fv5A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)
2fv5 ADAM 17
(Homo
sapiens)
4 / 5 HIS A 405
GLU A 406
HIS A 409
HIS A 415
ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
0.29A 3kecA-2fv5A:
9.7
3kecA-2fv5A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)
2fv5 ADAM 17
(Homo
sapiens)
4 / 5 HIS A 405
GLU A 406
HIS A 409
HIS A 415
ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
0.27A 3likA-2fv5A:
9.9
3likA-2fv5A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)
2fv5 ADAM 17
(Homo
sapiens)
4 / 4 HIS A 405
GLU A 406
HIS A 409
HIS A 415
ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
0.28A 3lilA-2fv5A:
9.8
3lilA-2fv5A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)
2fv5 ADAM 17
(Homo
sapiens)
4 / 5 HIS A 405
GLU A 406
HIS A 409
HIS A 415
ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
0.26A 3ljgA-2fv5A:
10.0
3ljgA-2fv5A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)
2fv5 ADAM 17
(Homo
sapiens)
4 / 5 HIS A 405
GLU A 406
HIS A 409
HIS A 415
ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
0.24A 3lkaA-2fv5A:
9.9
3lkaA-2fv5A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)
2fv5 ADAM 17
(Homo
sapiens)
4 / 6 HIS A 405
GLU A 406
HIS A 409
HIS A 415
ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
0.41A 4a7bA-2fv5A:
9.3
4a7bA-2fv5A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)
2fv5 ADAM 17
(Homo
sapiens)
5 / 12 VAL A 364
THR A 404
ILE A 458
SER A 454
HIS A 405
None
None
None
None
ZN  A   3 ( 3.2A)
1.26A 4c49C-2fv5A:
undetectable
4c49C-2fv5A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB6_A_DXCA75_0
(PPCA)
2fv5 ADAM 17
(Homo
sapiens)
4 / 8 ILE A 277
LEU A 334
ILE A 462
GLY A 353
None
0.83A 4hb6A-2fv5A:
undetectable
4hb6A-2fv5A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)
2fv5 ADAM 17
(Homo
sapiens)
4 / 8 ASP A 416
SER A 451
ALA A 413
SER A 457
None
0.98A 4lv9A-2fv5A:
undetectable
4lv9B-2fv5A:
undetectable
4lv9A-2fv5A:
19.01
4lv9B-2fv5A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)
2fv5 ADAM 17
(Homo
sapiens)
4 / 7 ASP A 416
SER A 451
ALA A 413
SER A 457
None
1.00A 4lv9A-2fv5A:
undetectable
4lv9B-2fv5A:
undetectable
4lv9A-2fv5A:
19.01
4lv9B-2fv5A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)
2fv5 ADAM 17
(Homo
sapiens)
4 / 6 LEU A 251
PHE A 338
THR A 385
VAL A 402
None
None
None
541  A   1 ( 4.1A)
1.09A 4udaA-2fv5A:
undetectable
4udaA-2fv5A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
2fv5 ADAM 17
(Homo
sapiens)
3 / 3 PHE A 470
ILE A 462
ASP A 217
None
0.70A 5cswA-2fv5A:
undetectable
5cswA-2fv5A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
2fv5 ADAM 17
(Homo
sapiens)
3 / 3 PHE A 470
ILE A 462
ASP A 217
None
0.65A 5cswB-2fv5A:
undetectable
5cswB-2fv5A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)
2fv5 ADAM 17
(Homo
sapiens)
4 / 4 HIS A 405
GLU A 406
HIS A 409
HIS A 415
ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
0.25A 5n5jA-2fv5A:
10.0
5n5jA-2fv5A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)
2fv5 ADAM 17
(Homo
sapiens)
4 / 5 HIS A 405
GLU A 406
HIS A 409
HIS A 415
ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
0.25A 5n5kA-2fv5A:
10.0
5n5kA-2fv5A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_A_CXQA507_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)
2fv5 ADAM 17
(Homo
sapiens)
4 / 5 ARG A 473
ALA A 476
GLN A 278
ILE A 279
None
1.35A 6f6sA-2fv5A:
undetectable
6f6sB-2fv5A:
undetectable
6f6sA-2fv5A:
16.81
6f6sB-2fv5A:
17.33