SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fv8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 2fv8 RHO-RELATED
GTP-BINDING PROTEIN
RHOB
(Homo
sapiens) 		4 / 8 VAL A 139
LEU A 114
GLY A 144
TYR A 156
 None
 0.98A 3af0A-2fv8A:
undetectable		 3af0A-2fv8A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 2fv8 RHO-RELATED
GTP-BINDING PROTEIN
RHOB
(Homo
sapiens) 		4 / 7 ASP A  87
SER A  85
GLU A  64
ASP A  65
 None
None
GDP  A 201 ( 4.8A)
None
 1.09A 3bc9A-2fv8A:
undetectable		 3bc9A-2fv8A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 2fv8 RHO-RELATED
GTP-BINDING PROTEIN
RHOB
(Homo
sapiens) 		5 / 12 LEU A  81
LEU A  55
VAL A  53
ALA A 174
THR A 175
 None
 0.95A 3r9cA-2fv8A:
undetectable		 3r9cA-2fv8A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2fv8 RHO-RELATED
GTP-BINDING PROTEIN
RHOB
(Homo
sapiens) 		3 / 3 LEU A 114
ILE A 151
ARG A 150
 None
 0.71A 4mk4B-2fv8A:
3.8		 4mk4B-2fv8A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 2fv8 RHO-RELATED
GTP-BINDING PROTEIN
RHOB
(Homo
sapiens) 		4 / 6 PHE A  25
TYR A  42
LEU A  57
THR A 175
 None
 1.33A 4paeA-2fv8A:
undetectable		 4paeA-2fv8A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2fv8 RHO-RELATED
GTP-BINDING PROTEIN
RHOB
(Homo
sapiens) 		4 / 7 GLY A 166
ASP A 155
ILE A 113
VAL A 115
 None
 0.69A 5ik1A-2fv8A:
undetectable		 5ik1A-2fv8A:
21.72