SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fvg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 2fvg ENDOGLUCANASE
(Thermotoga
maritima) 		5 / 12 ILE A 261
PRO A 212
LEU A  55
ILE A 334
THR A 245
 None
 1.01A 1cd2A-2fvgA:
undetectable		 1cd2A-2fvgA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 2fvg ENDOGLUCANASE
(Thermotoga
maritima) 		4 / 8 SER A  58
VAL A  57
TYR A 292
VAL A 338
 None
None
EDO  A 342 (-4.3A)
None
 0.95A 1fduB-2fvgA:
undetectable		 1fduB-2fvgA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2fvg ENDOGLUCANASE
(Thermotoga
maritima) 		3 / 3 ILE A 299
ILE A 216
THR A 301
 None
 0.65A 1rg7A-2fvgA:
undetectable		 1rg7A-2fvgA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)		 2fvg ENDOGLUCANASE
(Thermotoga
maritima) 		3 / 3 PRO A  91
LEU A 125
ARG A 107
 None
 0.80A 3aqiB-2fvgA:
undetectable		 3aqiB-2fvgA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SEL_X_DXCX75_0
(CYTOCHROME C7)		 2fvg ENDOGLUCANASE
(Thermotoga
maritima) 		5 / 8 ILE A  89
LEU A  90
LYS A 163
PHE A 149
GLY A  65
 None
None
None
EDO  A 341 (-4.7A)
None
 1.44A 3selX-2fvgA:
undetectable		 3selX-2fvgA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 2fvg ENDOGLUCANASE
(Thermotoga
maritima) 		5 / 11 ALA A 160
GLU A 155
LEU A 315
GLY A 239
LEU A 238
 None
 1.14A 3uudA-2fvgA:
undetectable		 3uudA-2fvgA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB6_A_DXCA75_0
(PPCA)		 2fvg ENDOGLUCANASE
(Thermotoga
maritima) 		5 / 8 ILE A  89
LEU A  90
LYS A 163
PHE A 149
GLY A  65
 None
None
None
EDO  A 341 (-4.7A)
None
 1.45A 4hb6A-2fvgA:
undetectable		 4hb6A-2fvgA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 2fvg ENDOGLUCANASE
(Thermotoga
maritima) 		5 / 12 ILE A 261
PRO A 212
LEU A  55
ILE A 334
THR A 245
 None
 1.01A 4m2xC-2fvgA:
undetectable		 4m2xC-2fvgA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 2fvg ENDOGLUCANASE
(Thermotoga
maritima) 		5 / 11 ALA A 160
GLU A 155
LEU A 315
GLY A 239
LEU A 238
 None
 1.16A 4pxmB-2fvgA:
undetectable		 4pxmB-2fvgA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2fvg ENDOGLUCANASE
(Thermotoga
maritima) 		5 / 12 GLU A 179
ASP A 176
GLU A  28
ALA A  59
PHE A  22
 None
 1.18A 4xe5A-2fvgA:
undetectable		 4xe5A-2fvgA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_1
(ESTROGEN RECEPTOR)		 2fvg ENDOGLUCANASE
(Thermotoga
maritima) 		5 / 12 ALA A 160
LEU A   3
LEU A 315
GLY A 239
LEU A 238
 None
 1.00A 4xi3B-2fvgA:
undetectable		 4xi3B-2fvgA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_1
(ESTROGEN RECEPTOR)		 2fvg ENDOGLUCANASE
(Thermotoga
maritima) 		5 / 12 ALA A 160
LEU A   3
LEU A 315
GLY A 239
LEU A 238
 None
 1.00A 4xi3C-2fvgA:
undetectable		 4xi3C-2fvgA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2fvg ENDOGLUCANASE
(Thermotoga
maritima) 		4 / 7 ALA A 243
ASP A 166
GLY A 170
THR A 193
 None
None
None
EDO  A 342 ( 4.0A)
 0.88A 5bs8A-2fvgA:
undetectable
5bs8C-2fvgA:
undetectable
5bs8D-2fvgA:
2.2		 5bs8A-2fvgA:
22.29
5bs8C-2fvgA:
22.29
5bs8D-2fvgA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2fvg ENDOGLUCANASE
(Thermotoga
maritima) 		4 / 7 ALA A 243
ASP A 166
GLY A 170
THR A 193
 None
None
None
EDO  A 342 ( 4.0A)
 0.90A 5btgA-2fvgA:
undetectable
5btgC-2fvgA:
undetectable
5btgD-2fvgA:
2.2		 5btgA-2fvgA:
22.29
5btgC-2fvgA:
22.29
5btgD-2fvgA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_A_ESTA601_1
(ESTROGEN RECEPTOR)		 2fvg ENDOGLUCANASE
(Thermotoga
maritima) 		5 / 10 ALA A 160
GLU A 155
LEU A 315
GLY A 239
LEU A 238
 None
 1.16A 5dx3A-2fvgA:
undetectable		 5dx3A-2fvgA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 2fvg ENDOGLUCANASE
(Thermotoga
maritima) 		5 / 10 ALA A 160
GLU A 155
LEU A 315
GLY A 239
LEU A 238
 None
 1.15A 5dxbA-2fvgA:
undetectable		 5dxbA-2fvgA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)		 2fvg ENDOGLUCANASE
(Thermotoga
maritima) 		5 / 11 ALA A 160
GLU A 155
LEU A 315
GLY A 239
LEU A 238
 None
 1.16A 5dxbB-2fvgA:
undetectable		 5dxbB-2fvgA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)		 2fvg ENDOGLUCANASE
(Thermotoga
maritima) 		5 / 11 ALA A 160
GLU A 155
LEU A 315
GLY A 239
LEU A 238
 None
 1.17A 5dxgB-2fvgA:
undetectable		 5dxgB-2fvgA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 2fvg ENDOGLUCANASE
(Thermotoga
maritima) 		4 / 6 PHE A 165
PHE A 190
SER A   7
ASP A 167
 None
 1.19A 5hesA-2fvgA:
undetectable		 5hesA-2fvgA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2fvg ENDOGLUCANASE
(Thermotoga
maritima) 		5 / 12 ASP A  62
HIS A  60
ALA A  59
GLN A 209
LEU A  56
 None
 1.38A 5syfB-2fvgA:
2.7		 5syfB-2fvgA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 2fvg ENDOGLUCANASE
(Thermotoga
maritima) 		5 / 9 ALA A 160
GLU A 155
LEU A 315
GLY A 239
LEU A 238
 None
 1.14A 5wgqA-2fvgA:
undetectable		 5wgqA-2fvgA:
14.24