SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fvl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		4 / 6 TYR A  24
TYR A  55
HIS A 117
VAL A 306
 None
NAP  A1001 (-4.7A)
NAP  A1001 (-4.4A)
None
 0.58A 1q13A-2fvlA:
52.3		 1q13A-2fvlA:
78.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1S2A_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		8 / 12 TYR A  24
LEU A  54
TRP A  86
HIS A 117
MET A 120
GLU A 192
SER A 217
GLN A 222
 None
None
None
NAP  A1001 (-4.4A)
None
None
NAP  A1001 (-4.0A)
NAP  A1001 (-4.0A)
 0.59A 1s2aA-2fvlA:
51.5		 1s2aA-2fvlA:
84.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XF0_A_ASDA600_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		5 / 9 LEU A  54
TRP A  86
MET A 120
ASN A 167
PRO A 318
 None
None
None
NAP  A1001 (-3.1A)
None
 0.51A 1xf0A-2fvlA:
51.5		 1xf0A-2fvlA:
84.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		4 / 6 ALA A 269
SER A 271
ASN A 280
ILE A 281
 NAP  A1001 ( 4.9A)
NAP  A1001 (-2.4A)
NAP  A1001 (-3.2A)
None
 1.02A 1yc2A-2fvlA:
undetectable		 1yc2A-2fvlA:
20.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F38_A_15MA325_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		6 / 12 TYR A  24
TRP A  86
MET A 120
LEU A 122
ASN A 167
PRO A 318
 None
None
None
None
NAP  A1001 (-3.1A)
None
 0.55A 2f38A-2fvlA:
52.1		 2f38A-2fvlA:
84.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		4 / 7 VAL A  35
LYS A  39
ILE A  42
GLY A  45
 None
 0.89A 3bjwB-2fvlA:
undetectable		 3bjwB-2fvlA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_3
(PHOSPHOLIPASE A2)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		4 / 7 VAL A  35
LYS A  39
ILE A  42
GLY A  45
 None
 0.84A 3bjwF-2fvlA:
undetectable		 3bjwF-2fvlA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		4 / 7 VAL A  35
LYS A  39
ILE A  42
GLY A  45
 None
 0.85A 3bjwH-2fvlA:
undetectable		 3bjwH-2fvlA:
16.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BUR_A_TESA339_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		6 / 10 TYR A  24
TRP A  86
THR A 221
TRP A 227
VAL A 228
VAL A 306
 None
None
NAP  A1001 (-4.7A)
None
None
None
 0.84A 3burA-2fvlA:
51.1		 3burA-2fvlA:
56.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BUR_B_TESB340_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		6 / 10 TYR A  24
TRP A  86
THR A 221
TRP A 227
VAL A 228
VAL A 306
 None
None
NAP  A1001 (-4.7A)
None
None
None
 0.72A 3burB-2fvlA:
51.3		 3burB-2fvlA:
56.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		5 / 12 HIS A 117
ILE A 163
GLY A 164
VAL A 214
ASP A  12
 NAP  A1001 (-4.4A)
None
None
None
None
 1.05A 3bwcA-2fvlA:
undetectable		 3bwcA-2fvlA:
23.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CAS_A_ASDA332_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		6 / 10 TYR A  24
TRP A  86
THR A 221
TRP A 227
VAL A 228
VAL A 306
 None
None
NAP  A1001 (-4.7A)
None
None
None
 0.79A 3casA-2fvlA:
50.8		 3casA-2fvlA:
56.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CAS_B_ASDB331_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		5 / 9 TRP A  86
THR A 221
TRP A 227
VAL A 228
VAL A 306
 None
NAP  A1001 (-4.7A)
None
None
None
 0.79A 3casB-2fvlA:
50.7		 3casB-2fvlA:
56.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CAS_B_ASDB331_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		5 / 9 TYR A  24
TRP A  86
THR A 221
VAL A 228
VAL A 306
 None
None
NAP  A1001 (-4.7A)
None
None
 0.59A 3casB-2fvlA:
50.7		 3casB-2fvlA:
56.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R43_A_ID8A332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		7 / 12 TYR A  24
LEU A  54
TYR A  55
TRP A  86
HIS A 117
MET A 120
ASN A 167
 None
None
NAP  A1001 (-4.7A)
None
NAP  A1001 (-4.4A)
None
NAP  A1001 (-3.1A)
 0.53A 3r43A-2fvlA:
51.1		 3r43A-2fvlA:
84.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R43_A_ID8A332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		5 / 12 TYR A  24
LEU A  54
TYR A  55
TRP A  86
PHE A 310
 None
None
NAP  A1001 (-4.7A)
None
None
 0.90A 3r43A-2fvlA:
51.1		 3r43A-2fvlA:
84.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R58_A_NPSA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		6 / 10 LEU A  54
TYR A  55
HIS A 117
MET A 120
ASN A 167
PRO A 318
 None
NAP  A1001 (-4.7A)
NAP  A1001 (-4.4A)
None
NAP  A1001 (-3.1A)
None
 0.51A 3r58A-2fvlA:
49.9		 3r58A-2fvlA:
84.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R6I_A_JMSA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		7 / 12 TYR A  24
LEU A  54
TYR A  55
TRP A  86
HIS A 117
MET A 120
ASN A 167
 None
None
NAP  A1001 (-4.7A)
None
NAP  A1001 (-4.4A)
None
NAP  A1001 (-3.1A)
 0.54A 3r6iA-2fvlA:
49.7		 3r6iA-2fvlA:
84.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R6I_A_JMSA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		5 / 12 TYR A  24
LEU A  54
TYR A  55
TRP A  86
PHE A 310
 None
None
NAP  A1001 (-4.7A)
None
None
 0.96A 3r6iA-2fvlA:
49.7		 3r6iA-2fvlA:
84.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R7M_A_SUZA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		6 / 10 TYR A  24
LEU A  54
TYR A  55
TRP A  86
HIS A 117
ASN A 167
 None
None
NAP  A1001 (-4.7A)
None
NAP  A1001 (-4.4A)
NAP  A1001 (-3.1A)
 0.24A 3r7mA-2fvlA:
49.7		 3r7mA-2fvlA:
84.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R7M_A_SUZA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		5 / 10 TYR A  24
LEU A  54
TYR A  55
TRP A  86
PHE A 310
 None
None
NAP  A1001 (-4.7A)
None
None
 1.03A 3r7mA-2fvlA:
49.7		 3r7mA-2fvlA:
84.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R8G_A_IZPA409_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		6 / 9 LEU A  54
TYR A  55
HIS A 117
MET A 120
ASN A 167
PRO A 318
 None
NAP  A1001 (-4.7A)
NAP  A1001 (-4.4A)
None
NAP  A1001 (-3.1A)
None
 0.46A 3r8gA-2fvlA:
49.9		 3r8gA-2fvlA:
84.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R94_A_FLRA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		6 / 12 LEU A  54
TYR A  55
HIS A 117
MET A 120
ASN A 167
PRO A 318
 None
NAP  A1001 (-4.7A)
NAP  A1001 (-4.4A)
None
NAP  A1001 (-3.1A)
None
 0.50A 3r94A-2fvlA:
49.6		 3r94A-2fvlA:
84.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		5 / 12 ALA A 269
LEU A 261
ALA A 253
THR A 251
VAL A 283
 NAP  A1001 ( 4.9A)
None
NAP  A1001 (-3.4A)
None
None
 0.96A 3rukA-2fvlA:
undetectable		 3rukA-2fvlA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		5 / 12 ALA A 269
LEU A 261
ALA A 253
THR A 251
VAL A 283
 NAP  A1001 ( 4.9A)
None
NAP  A1001 (-3.4A)
None
None
 0.94A 3rukB-2fvlA:
undetectable		 3rukB-2fvlA:
21.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG8_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		8 / 12 LEU A  54
TYR A  55
TRP A  86
HIS A 117
MET A 120
ASN A 167
SER A 217
PRO A 318
 None
NAP  A1001 (-4.7A)
None
NAP  A1001 (-4.4A)
None
NAP  A1001 (-3.1A)
NAP  A1001 (-4.0A)
None
 0.59A 3ug8A-2fvlA:
49.8		 3ug8A-2fvlA:
84.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		3 / 3 TYR A  24
GLU A 192
TYR A 305
 None
 0.23A 3ug8A-2fvlA:
49.8		 3ug8A-2fvlA:
84.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UGR_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		6 / 12 TYR A  24
LEU A  54
TRP A  86
HIS A 117
MET A 120
SER A 217
 None
None
None
NAP  A1001 (-4.4A)
None
NAP  A1001 (-4.0A)
 0.47A 3ugrA-2fvlA:
50.0		 3ugrA-2fvlA:
84.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		6 / 7 TYR A  55
ASN A 167
GLU A 192
GLN A 222
TYR A 305
PRO A 318
 NAP  A1001 (-4.7A)
NAP  A1001 (-3.1A)
None
NAP  A1001 (-4.0A)
None
None
 0.56A 3ugrA-2fvlA:
50.0		 3ugrA-2fvlA:
84.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		4 / 8 TYR A  24
TYR A  55
HIS A 117
LEU A 129
 None
NAP  A1001 (-4.7A)
NAP  A1001 (-4.4A)
None
 1.24A 3uzzB-2fvlA:
51.0		 3uzzB-2fvlA:
53.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		4 / 6 ALA A 218
ALA A 253
PRO A 252
LEU A 235
 None
NAP  A1001 (-3.4A)
None
None
 0.99A 4dtzA-2fvlA:
undetectable		 4dtzA-2fvlA:
22.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JQ1_A_NPSA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		5 / 9 TYR A  24
TYR A  55
TRP A  86
HIS A 117
TRP A 227
 None
NAP  A1001 (-4.7A)
None
NAP  A1001 (-4.4A)
None
 0.44A 4jq1A-2fvlA:
52.1		 4jq1A-2fvlA:
81.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		4 / 8 TYR A  55
TRP A  86
HIS A 117
TRP A 227
 NAP  A1001 (-4.7A)
None
NAP  A1001 (-4.4A)
None
 0.67A 4jq1B-2fvlA:
51.9		 4jq1B-2fvlA:
81.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JQA_A_ID8A401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		5 / 9 TYR A  24
TYR A  55
TRP A  86
HIS A 117
TRP A 227
 None
NAP  A1001 (-4.7A)
None
NAP  A1001 (-4.4A)
None
 0.81A 4jqaA-2fvlA:
52.1		 4jqaA-2fvlA:
81.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JQA_B_ID8B401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		5 / 9 TYR A  24
TYR A  55
TRP A  86
HIS A 117
TRP A 227
 None
NAP  A1001 (-4.7A)
None
NAP  A1001 (-4.4A)
None
 0.84A 4jqaB-2fvlA:
52.6		 4jqaB-2fvlA:
81.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		4 / 8 TYR A  24
TYR A  55
TRP A  86
HIS A 117
 None
NAP  A1001 (-4.7A)
None
NAP  A1001 (-4.4A)
 0.15A 4jtrA-2fvlA:
51.9		 4jtrA-2fvlA:
81.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JTR_B_IZPB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		4 / 6 TYR A  24
TYR A  55
TRP A  86
HIS A 117
 None
NAP  A1001 (-4.7A)
None
NAP  A1001 (-4.4A)
 0.18A 4jtrB-2fvlA:
52.4		 4jtrB-2fvlA:
81.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		4 / 8 LEU A 108
LEU A 106
ASP A  50
ILE A  49
 None
None
NAP  A1001 (-3.7A)
None
 0.88A 4lzrA-2fvlA:
undetectable		 4lzrA-2fvlA:
17.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVP_A_GBMA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		5 / 11 TYR A  24
LEU A  54
TYR A  55
TRP A  86
HIS A 117
 None
None
NAP  A1001 (-4.7A)
None
NAP  A1001 (-4.4A)
 0.24A 4yvpA-2fvlA:
52.5		 4yvpA-2fvlA:
82.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		6 / 12 TYR A  24
LEU A  54
TYR A  55
TRP A  86
HIS A 117
ASN A 167
 None
None
NAP  A1001 (-4.7A)
None
NAP  A1001 (-4.4A)
NAP  A1001 (-3.1A)
 0.23A 4yvpB-2fvlA:
52.6		 4yvpB-2fvlA:
82.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVV_A_GBMA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		6 / 9 TYR A  24
LEU A  54
TYR A  55
TRP A  86
HIS A 117
ASN A 167
 None
None
NAP  A1001 (-4.7A)
None
NAP  A1001 (-4.4A)
NAP  A1001 (-3.1A)
 0.17A 4yvvA-2fvlA:
51.9		 4yvvA-2fvlA:
84.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVV_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		6 / 9 TYR A  24
LEU A  54
TYR A  55
TRP A  86
HIS A 117
ASN A 167
 None
None
NAP  A1001 (-4.7A)
None
NAP  A1001 (-4.4A)
NAP  A1001 (-3.1A)
 0.20A 4yvvB-2fvlA:
51.9		 4yvvB-2fvlA:
84.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVX_A_GMRA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		7 / 12 TYR A  24
LEU A  54
TYR A  55
TRP A  86
HIS A 117
LEU A 122
ASN A 167
 None
None
NAP  A1001 (-4.7A)
None
NAP  A1001 (-4.4A)
None
NAP  A1001 (-3.1A)
 0.24A 4yvxA-2fvlA:
51.6		 4yvxA-2fvlA:
84.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVX_B_GMRB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		8 / 12 TYR A  24
LEU A  54
TYR A  55
TRP A  86
HIS A 117
MET A 120
LEU A 122
ASN A 167
 None
None
NAP  A1001 (-4.7A)
None
NAP  A1001 (-4.4A)
None
None
NAP  A1001 (-3.1A)
 0.41A 4yvxB-2fvlA:
51.4		 4yvxB-2fvlA:
84.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZFC_A_GCZA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		7 / 9 TYR A  24
LEU A  54
TYR A  55
TRP A  86
HIS A 117
MET A 120
ASN A 167
 None
None
NAP  A1001 (-4.7A)
None
NAP  A1001 (-4.4A)
None
NAP  A1001 (-3.1A)
 0.43A 4zfcA-2fvlA:
51.9		 4zfcA-2fvlA:
84.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZFC_B_GCZB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		7 / 9 TYR A  24
LEU A  54
TYR A  55
TRP A  86
HIS A 117
MET A 120
ASN A 167
 None
None
NAP  A1001 (-4.7A)
None
NAP  A1001 (-4.4A)
None
NAP  A1001 (-3.1A)
 0.41A 4zfcB-2fvlA:
52.2		 4zfcB-2fvlA:
84.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		3 / 3 ASP A   2
LEU A 261
ARG A 258
 None
 0.82A 5e8qA-2fvlA:
undetectable		 5e8qA-2fvlA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		3 / 3 LEU A 244
ALA A 245
LEU A 296
 None
 0.41A 5uunB-2fvlA:
undetectable		 5uunB-2fvlA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		4 / 5 PHE A  89
PHE A  90
LEU A  85
LEU A 129
 None
 1.30A 5veuH-2fvlA:
undetectable		 5veuH-2fvlA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA605_0
(ALPHA-AMYLASE)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		4 / 8 ILE A 138
ASP A 313
HIS A 314
PRO A 315
 None
 0.77A 6ag0A-2fvlA:
8.1		 6ag0A-2fvlA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC605_0
(ALPHA-AMYLASE)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		4 / 8 ILE A 138
ASP A 313
HIS A 314
PRO A 315
 None
 0.83A 6ag0C-2fvlA:
8.3		 6ag0C-2fvlA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens) 		4 / 6 TYR A 114
GLN A 190
GLU A  58
ALA A  98
 None
NAP  A1001 (-4.0A)
None
None
 1.26A 6djzB-2fvlA:
undetectable		 6djzB-2fvlA:
21.52