SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fvm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		 2fvm DIHYDROPYRIMIDINASE
(Lachancea
kluyveri) 		5 / 8 ALA A 277
GLY A 346
ILE A 343
VAL A 264
ILE A 265
 None
 1.18A 1d4yB-2fvmA:
undetectable		 1d4yB-2fvmA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 2fvm DIHYDROPYRIMIDINASE
(Lachancea
kluyveri) 		4 / 5 HIS A  62
HIS A 199
HIS A 255
ASP A 358
 ZN  A 601 (-3.2A)
ZN  A 602 (-3.4A)
ZN  A 602 ( 3.5A)
ZN  A 601 ( 3.1A)
 0.65A 1e9yB-2fvmA:
19.7		 1e9yB-2fvmA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 2fvm DIHYDROPYRIMIDINASE
(Lachancea
kluyveri) 		5 / 6 HIS A  62
HIS A  64
HIS A 199
HIS A 255
ASP A 358
 ZN  A 601 (-3.2A)
ZN  A 601 ( 3.4A)
ZN  A 602 (-3.4A)
ZN  A 602 ( 3.5A)
ZN  A 601 ( 3.1A)
 0.73A 1fweC-2fvmA:
20.7		 1fweC-2fvmA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_2
(ADENOSINE KINASE)		 2fvm DIHYDROPYRIMIDINASE
(Lachancea
kluyveri) 		4 / 4 SER A 331
LEU A  72
TYR A 172
GLY A 393
 URP  A 604 (-4.4A)
URP  A 604 ( 4.9A)
None
URP  A 604 (-3.4A)
 1.38A 1liiA-2fvmA:
2.6		 1liiA-2fvmA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2fvm DIHYDROPYRIMIDINASE
(Lachancea
kluyveri) 		5 / 12 GLU A 278
HIS A 255
HIS A 224
HIS A 199
TYR A 172
 None
ZN  A 602 ( 3.5A)
None
ZN  A 602 (-3.4A)
None
 1.46A 1o86A-2fvmA:
undetectable		 1o86A-2fvmA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 2fvm DIHYDROPYRIMIDINASE
(Lachancea
kluyveri) 		3 / 3 ASP A 479
LYS A 373
ARG A 375
 None
 1.15A 1ra8A-2fvmA:
undetectable		 1ra8A-2fvmA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 2fvm DIHYDROPYRIMIDINASE
(Lachancea
kluyveri) 		3 / 3 ARG A 493
TYR A 462
LYS A 460
 None
 0.69A 1uujB-2fvmA:
undetectable		 1uujB-2fvmA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 2fvm DIHYDROPYRIMIDINASE
(Lachancea
kluyveri) 		5 / 8 VAL A 206
ARG A 335
THR A 171
THR A 237
ALA A 236
 None
 1.11A 2a1hA-2fvmA:
undetectable
2a1hB-2fvmA:
undetectable		 2a1hA-2fvmA:
21.08
2a1hB-2fvmA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 2fvm DIHYDROPYRIMIDINASE
(Lachancea
kluyveri) 		5 / 11 ARG A 335
THR A 171
THR A 237
ALA A 236
VAL A 206
 None
 1.18A 2cojA-2fvmA:
undetectable
2cojB-2fvmA:
undetectable		 2cojA-2fvmA:
22.51
2cojB-2fvmA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACHA546_0
(ACETYLCHOLINESTERASE)		 2fvm DIHYDROPYRIMIDINASE
(Lachancea
kluyveri) 		4 / 8 GLU A 278
PHE A  97
HIS A  62
GLY A 356
 None
KCX  A 167 ( 4.5A)
ZN  A 601 (-3.2A)
None
 1.07A 2ha4A-2fvmA:
undetectable		 2ha4A-2fvmA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		 2fvm DIHYDROPYRIMIDINASE
(Lachancea
kluyveri) 		4 / 6 ASP A  66
VAL A  75
PRO A  68
THR A  99
 None
 1.15A 2q6oB-2fvmA:
undetectable		 2q6oB-2fvmA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 2fvm DIHYDROPYRIMIDINASE
(Lachancea
kluyveri) 		5 / 12 TYR A 503
LEU A 473
GLY A  90
PRO A 402
ASP A 129
 None
 1.40A 2zznB-2fvmA:
undetectable		 2zznB-2fvmA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 2fvm DIHYDROPYRIMIDINASE
(Lachancea
kluyveri) 		5 / 12 ARG A 520
ALA A  61
ASP A  60
ALA A  82
PHE A  97
 None
None
None
None
KCX  A 167 ( 4.5A)
 1.03A 3axtA-2fvmA:
2.5		 3axtA-2fvmA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 2fvm DIHYDROPYRIMIDINASE
(Lachancea
kluyveri) 		3 / 3 TYR A 503
TYR A 454
GLY A 506
 None
 0.67A 3eteB-2fvmA:
undetectable
3eteD-2fvmA:
undetectable
3eteF-2fvmA:
undetectable		 3eteB-2fvmA:
21.33
3eteD-2fvmA:
21.33
3eteF-2fvmA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		 2fvm DIHYDROPYRIMIDINASE
(Lachancea
kluyveri) 		5 / 9 ILE A 452
TYR A 494
ILE A 496
LEU A   6
GLU A  45
 None
 1.22A 3f78A-2fvmA:
undetectable		 3f78A-2fvmA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_B_ICFB2_1
(INTEGRIN ALPHA-L)		 2fvm DIHYDROPYRIMIDINASE
(Lachancea
kluyveri) 		5 / 9 ILE A 452
TYR A 494
ILE A 496
LEU A   6
GLU A  45
 None
 1.15A 3f78B-2fvmA:
undetectable		 3f78B-2fvmA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2fvm DIHYDROPYRIMIDINASE
(Lachancea
kluyveri) 		3 / 3 LEU A 213
LEU A 218
ARG A 292
 None
 0.60A 3hcnB-2fvmA:
undetectable		 3hcnB-2fvmA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_1
(STRUCTURAL PROTEIN
VP3)		 2fvm DIHYDROPYRIMIDINASE
(Lachancea
kluyveri) 		3 / 3 GLU A 112
ASP A 101
ASP A 119
 None
 0.77A 3jb2A-2fvmA:
undetectable		 3jb2A-2fvmA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 2fvm DIHYDROPYRIMIDINASE
(Lachancea
kluyveri) 		3 / 3 ARG A 335
VAL A 264
THR A 237
 None
 0.87A 3pwrA-2fvmA:
undetectable		 3pwrA-2fvmA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2fvm DIHYDROPYRIMIDINASE
(Lachancea
kluyveri) 		4 / 4 GLY A  90
GLY A  57
THR A  55
LEU A 420
 None
 0.93A 3si7C-2fvmA:
undetectable
3si7D-2fvmA:
undetectable		 3si7C-2fvmA:
19.93
3si7D-2fvmA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_2
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 2fvm DIHYDROPYRIMIDINASE
(Lachancea
kluyveri) 		4 / 4 PRO A 250
LEU A 252
HIS A 133
LEU A 132
 None
 1.28A 3vw7A-2fvmA:
0.0		 3vw7A-2fvmA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 2fvm DIHYDROPYRIMIDINASE
(Lachancea
kluyveri) 		4 / 8 ASP A 358
PHE A 169
LEU A  72
HIS A  62
 ZN  A 601 ( 3.1A)
KCX  A 167 ( 4.2A)
URP  A 604 ( 4.9A)
ZN  A 601 (-3.2A)
 1.19A 4f5zA-2fvmA:
2.3		 4f5zA-2fvmA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 2fvm DIHYDROPYRIMIDINASE
(Lachancea
kluyveri) 		4 / 5 HIS A  62
HIS A 199
HIS A 255
ASP A 358
 ZN  A 601 (-3.2A)
ZN  A 602 (-3.4A)
ZN  A 602 ( 3.5A)
ZN  A 601 ( 3.1A)
 0.61A 4h9mA-2fvmA:
21.4		 4h9mA-2fvmA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K17_B_OHBB701_0
(LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A)		 2fvm DIHYDROPYRIMIDINASE
(Lachancea
kluyveri) 		5 / 5 GLU A 201
SER A 258
ARG A 228
PRO A 332
SER A 257
 None
 1.41A 4k17B-2fvmA:
undetectable		 4k17B-2fvmA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)		 2fvm DIHYDROPYRIMIDINASE
(Lachancea
kluyveri) 		4 / 8 ASP A 129
TYR A 130
GLY A 515
ALA A  86
 None
 0.92A 4m48A-2fvmA:
undetectable		 4m48A-2fvmA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 2fvm DIHYDROPYRIMIDINASE
(Lachancea
kluyveri) 		3 / 3 VAL A  63
ALA A  61
PHE A  97
 None
None
KCX  A 167 ( 4.5A)
 0.86A 4olbA-2fvmA:
undetectable		 4olbA-2fvmA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 2fvm DIHYDROPYRIMIDINASE
(Lachancea
kluyveri) 		5 / 6 HIS A  62
HIS A  64
HIS A 199
HIS A 255
ASP A 358
 ZN  A 601 (-3.2A)
ZN  A 601 ( 3.4A)
ZN  A 602 (-3.4A)
ZN  A 602 ( 3.5A)
ZN  A 601 ( 3.1A)
 0.61A 4ubpC-2fvmA:
20.3		 4ubpC-2fvmA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2fvm DIHYDROPYRIMIDINASE
(Lachancea
kluyveri) 		3 / 3 VAL A  63
ALA A  61
PHE A  97
 None
None
KCX  A 167 ( 4.5A)
 0.94A 4w5nA-2fvmA:
undetectable		 4w5nA-2fvmA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 2fvm DIHYDROPYRIMIDINASE
(Lachancea
kluyveri) 		3 / 3 VAL A  63
ALA A  61
PHE A  97
 None
None
KCX  A 167 ( 4.5A)
 0.85A 4z4iA-2fvmA:
undetectable		 4z4iA-2fvmA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 2fvm DIHYDROPYRIMIDINASE
(Lachancea
kluyveri) 		5 / 12 GLY A 356
SER A 257
PHE A 253
GLU A 233
LEU A 252
 None
 1.13A 5czyA-2fvmA:
0.9		 5czyA-2fvmA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 2fvm DIHYDROPYRIMIDINASE
(Lachancea
kluyveri) 		4 / 4 CYH A 526
PHE A 524
ILE A 354
GLY A 433
 None
 1.36A 5hesB-2fvmA:
0.0		 5hesB-2fvmA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 2fvm DIHYDROPYRIMIDINASE
(Lachancea
kluyveri) 		5 / 12 TYR A 328
LEU A 286
ILE A 486
GLY A 485
ILE A 469
 None
 1.20A 5ifuA-2fvmA:
undetectable		 5ifuA-2fvmA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2fvm DIHYDROPYRIMIDINASE
(Lachancea
kluyveri) 		3 / 3 VAL A  63
ALA A  61
PHE A  97
 None
None
KCX  A 167 ( 4.5A)
 0.86A 5js1A-2fvmA:
1.8		 5js1A-2fvmA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2fvm DIHYDROPYRIMIDINASE
(Lachancea
kluyveri) 		3 / 3 LYS A   9
LEU A 450
ILE A  13
 None
 0.72A 5kc0A-2fvmA:
undetectable		 5kc0A-2fvmA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L7I_A_VISA1202_1
(SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG)		 2fvm DIHYDROPYRIMIDINASE
(Lachancea
kluyveri) 		5 / 12 ASP A 307
SER A 310
ARG A 411
GLU A 487
LEU A 468
 None
 1.36A 5l7iA-2fvmA:
0.3		 5l7iA-2fvmA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L7I_B_VISB1202_1
(SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG)		 2fvm DIHYDROPYRIMIDINASE
(Lachancea
kluyveri) 		5 / 12 ASP A 307
SER A 310
ARG A 411
GLU A 487
LEU A 468
 None
 1.36A 5l7iB-2fvmA:
0.1		 5l7iB-2fvmA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_K_BO2K305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 2fvm DIHYDROPYRIMIDINASE
(Lachancea
kluyveri) 		5 / 11 THR A  83
ALA A  82
GLY A  90
GLY A  89
ALA A  88
 None
 0.92A 5lf3K-2fvmA:
undetectable
5lf3L-2fvmA:
undetectable		 5lf3K-2fvmA:
18.65
5lf3L-2fvmA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_Y_BO2Y305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 2fvm DIHYDROPYRIMIDINASE
(Lachancea
kluyveri) 		5 / 11 THR A  83
ALA A  82
GLY A  90
GLY A  89
ALA A  88
 None
 0.92A 5lf3Y-2fvmA:
undetectable
5lf3Z-2fvmA:
undetectable		 5lf3Y-2fvmA:
18.65
5lf3Z-2fvmA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 2fvm DIHYDROPYRIMIDINASE
(Lachancea
kluyveri) 		5 / 11 THR A  83
ALA A  82
GLY A  90
GLY A  89
ALA A  88
 None
 0.96A 5lf7K-2fvmA:
undetectable
5lf7L-2fvmA:
undetectable		 5lf7K-2fvmA:
18.65
5lf7L-2fvmA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 2fvm DIHYDROPYRIMIDINASE
(Lachancea
kluyveri) 		5 / 11 THR A  83
ALA A  82
GLY A  90
GLY A  89
ALA A  88
 None
 0.94A 5lf7Y-2fvmA:
undetectable
5lf7Z-2fvmA:
undetectable		 5lf7Y-2fvmA:
18.65
5lf7Z-2fvmA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2fvm DIHYDROPYRIMIDINASE
(Lachancea
kluyveri) 		3 / 3 THR A 125
MET A  79
HIS A  81
 None
 0.99A 5uunA-2fvmA:
undetectable		 5uunA-2fvmA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 2fvm DIHYDROPYRIMIDINASE
(Lachancea
kluyveri) 		5 / 12 LEU A 175
GLY A 393
ILE A 135
PHE A  97
GLU A 201
 None
URP  A 604 (-3.4A)
KCX  A 167 ( 4.4A)
KCX  A 167 ( 4.5A)
None
 1.03A 5veuH-2fvmA:
undetectable		 5veuH-2fvmA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_K_BO2K301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2fvm DIHYDROPYRIMIDINASE
(Lachancea
kluyveri) 		5 / 11 THR A  83
ALA A  82
GLY A  90
GLY A  89
ALA A  88
 None
 0.91A 6hwdK-2fvmA:
undetectable
6hwdL-2fvmA:
undetectable		 6hwdK-2fvmA:
9.39
6hwdL-2fvmA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_Y_BO2Y301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2fvm DIHYDROPYRIMIDINASE
(Lachancea
kluyveri) 		5 / 11 THR A  83
ALA A  82
GLY A  90
GLY A  89
ALA A  88
 None
 0.91A 6hwdY-2fvmA:
undetectable
6hwdZ-2fvmA:
undetectable		 6hwdY-2fvmA:
9.39
6hwdZ-2fvmA:
10.50