SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fvz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 2fvz INOSITOL
MONOPHOSPHATASE 2
(Homo
sapiens) 		4 / 8 ASP A 179
PHE A 186
THR A 182
ILE A 174
 None
 0.92A 1ei6C-2fvzA:
undetectable		 1ei6C-2fvzA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 2fvz INOSITOL
MONOPHOSPHATASE 2
(Homo
sapiens) 		5 / 11 LEU A 227
ALA A 168
ALA A 221
VAL A 261
LEU A 211
 None
 1.27A 1hbpA-2fvzA:
1.3		 1hbpA-2fvzA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 2fvz INOSITOL
MONOPHOSPHATASE 2
(Homo
sapiens) 		5 / 8 GLY A  31
ILE A  33
PRO A 102
ILE A 100
ILE A 120
 None
 1.32A 1hshD-2fvzA:
undetectable		 1hshD-2fvzA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2fvz INOSITOL
MONOPHOSPHATASE 2
(Homo
sapiens) 		5 / 12 LEU A 209
CYH A 212
LEU A 214
VAL A 261
TYR A 222
 None
 1.05A 1s9pB-2fvzA:
undetectable		 1s9pB-2fvzA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 2fvz INOSITOL
MONOPHOSPHATASE 2
(Homo
sapiens) 		4 / 8 SER A 206
LEU A 209
SER A 207
ASP A 231
 None
 1.06A 2j2pA-2fvzA:
undetectable
2j2pB-2fvzA:
undetectable		 2j2pA-2fvzA:
19.49
2j2pB-2fvzA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		 2fvz INOSITOL
MONOPHOSPHATASE 2
(Homo
sapiens) 		5 / 9 GLY A 205
SER A 206
LEU A 209
SER A 207
ASP A 231
 None
 1.31A 2j2pB-2fvzA:
undetectable
2j2pC-2fvzA:
undetectable		 2j2pB-2fvzA:
19.49
2j2pC-2fvzA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 2fvz INOSITOL
MONOPHOSPHATASE 2
(Homo
sapiens) 		4 / 6 SER A 206
LEU A 209
SER A 207
ASP A 231
 None
 1.03A 2j2pE-2fvzA:
undetectable
2j2pF-2fvzA:
undetectable		 2j2pE-2fvzA:
19.49
2j2pF-2fvzA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)		 2fvz INOSITOL
MONOPHOSPHATASE 2
(Homo
sapiens) 		5 / 12 GLY A 105
ALA A 210
LEU A 209
PHE A 109
ASP A 104
 None
 1.04A 2yvlD-2fvzA:
undetectable		 2yvlD-2fvzA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2fvz INOSITOL
MONOPHOSPHATASE 2
(Homo
sapiens) 		5 / 8 LEU A 128
LEU A 232
ILE A 239
VAL A 246
LEU A 254
 None
 1.24A 3kp6A-2fvzA:
undetectable
3kp6B-2fvzA:
undetectable		 3kp6A-2fvzA:
22.11
3kp6B-2fvzA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2fvz INOSITOL
MONOPHOSPHATASE 2
(Homo
sapiens) 		4 / 6 ILE A 120
VAL A 132
LEU A 141
LEU A  28
 None
 0.81A 3kp6A-2fvzA:
undetectable
3kp6B-2fvzA:
undetectable		 3kp6A-2fvzA:
22.11
3kp6B-2fvzA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 2fvz INOSITOL
MONOPHOSPHATASE 2
(Homo
sapiens) 		4 / 8 ASP A 231
ASP A 104
ASP A 101
ILE A  34
 None
 0.87A 4xjeA-2fvzA:
undetectable		 4xjeA-2fvzA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 2fvz INOSITOL
MONOPHOSPHATASE 2
(Homo
sapiens) 		4 / 8 ASP A 231
ASP A 104
ASP A 101
ILE A  34
 None
 0.83A 5cfsA-2fvzA:
undetectable		 5cfsA-2fvzA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 2fvz INOSITOL
MONOPHOSPHATASE 2
(Homo
sapiens) 		5 / 12 ILE A 239
GLY A 244
ALA A 263
LEU A 211
VAL A 261
 None
 1.00A 5hw4A-2fvzA:
undetectable		 5hw4A-2fvzA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 2fvz INOSITOL
MONOPHOSPHATASE 2
(Homo
sapiens) 		5 / 11 ILE A 239
GLY A 244
ALA A 263
LEU A 211
VAL A 261
 None
 1.00A 5hw4B-2fvzA:
undetectable		 5hw4B-2fvzA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 2fvz INOSITOL
MONOPHOSPHATASE 2
(Homo
sapiens) 		5 / 12 ILE A 239
GLY A 244
ALA A 263
LEU A 211
VAL A 261
 None
 0.98A 5hw4C-2fvzA:
undetectable		 5hw4C-2fvzA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 2fvz INOSITOL
MONOPHOSPHATASE 2
(Homo
sapiens) 		5 / 12 GLY A 121
TYR A 134
ILE A  79
ALA A 123
ALA A 233
 None
 1.01A 5kvaA-2fvzA:
undetectable		 5kvaA-2fvzA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 2fvz INOSITOL
MONOPHOSPHATASE 2
(Homo
sapiens) 		5 / 12 GLY A 121
TYR A 134
ILE A  79
ALA A 123
ALA A 233
 None
 1.02A 5kvaB-2fvzA:
undetectable		 5kvaB-2fvzA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2fvz INOSITOL
MONOPHOSPHATASE 2
(Homo
sapiens) 		5 / 10 LEU A 211
HIS A 213
ILE A 239
GLY A 217
ALA A 263
 None
 1.02A 5o96C-2fvzA:
2.2
5o96D-2fvzA:
2.5		 5o96C-2fvzA:
22.76
5o96D-2fvzA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 2fvz INOSITOL
MONOPHOSPHATASE 2
(Homo
sapiens) 		3 / 3 TRP A  98
GLU A  68
GLU A  18
 None
 0.99A 6fhwA-2fvzA:
undetectable		 6fhwA-2fvzA:
14.81