SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fw2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2fw2 TESTIS-SPECIFIC
CHROMODOMAIN PROTEIN
Y 2
(Homo
sapiens) 		5 / 11 ILE A   6
ALA A  56
ILE A 103
LEU A  41
ILE A  17
 None
 1.06A 1dhiB-2fw2A:
undetectable		 1dhiB-2fw2A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2fw2 TESTIS-SPECIFIC
CHROMODOMAIN PROTEIN
Y 2
(Homo
sapiens) 		5 / 12 ILE A   6
ALA A  56
ILE A 103
LEU A  41
ILE A  17
 None
 1.04A 1draB-2fw2A:
undetectable		 1draB-2fw2A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_A_NIOA221_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2fw2 TESTIS-SPECIFIC
CHROMODOMAIN PROTEIN
Y 2
(Homo
sapiens) 		4 / 6 SER A  23
THR A  24
PHE A  70
GLU A  32
 None
 0.82A 1icuA-2fw2A:
undetectable
1icuB-2fw2A:
undetectable		 1icuA-2fw2A:
22.26
1icuB-2fw2A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_B_NIOB219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2fw2 TESTIS-SPECIFIC
CHROMODOMAIN PROTEIN
Y 2
(Homo
sapiens) 		4 / 6 PHE A  70
GLU A  32
SER A  23
THR A  24
 None
 0.87A 1icuA-2fw2A:
undetectable
1icuB-2fw2A:
undetectable		 1icuA-2fw2A:
22.26
1icuB-2fw2A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2fw2 TESTIS-SPECIFIC
CHROMODOMAIN PROTEIN
Y 2
(Homo
sapiens) 		4 / 6 SER A  23
THR A  24
PHE A  70
GLU A  32
 None
 0.86A 1icuC-2fw2A:
undetectable
1icuD-2fw2A:
undetectable		 1icuC-2fw2A:
22.26
1icuD-2fw2A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2fw2 TESTIS-SPECIFIC
CHROMODOMAIN PROTEIN
Y 2
(Homo
sapiens) 		4 / 6 SER A  23
THR A  24
PHE A  70
GLU A  32
 None
 0.81A 1kqbA-2fw2A:
undetectable
1kqbB-2fw2A:
undetectable		 1kqbA-2fw2A:
20.44
1kqbB-2fw2A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_C_BEZC522_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2fw2 TESTIS-SPECIFIC
CHROMODOMAIN PROTEIN
Y 2
(Homo
sapiens) 		4 / 6 SER A  23
THR A  24
PHE A  70
GLU A  32
 None
 0.80A 1kqbC-2fw2A:
undetectable
1kqbD-2fw2A:
undetectable		 1kqbC-2fw2A:
20.44
1kqbD-2fw2A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2fw2 TESTIS-SPECIFIC
CHROMODOMAIN PROTEIN
Y 2
(Homo
sapiens) 		4 / 6 PHE A  70
GLU A  32
SER A  23
THR A  24
 None
 0.79A 1kqbC-2fw2A:
undetectable
1kqbD-2fw2A:
undetectable		 1kqbC-2fw2A:
20.44
1kqbD-2fw2A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 2fw2 TESTIS-SPECIFIC
CHROMODOMAIN PROTEIN
Y 2
(Homo
sapiens) 		5 / 11 LEU A  29
PHE A  92
GLY A 115
VAL A 125
LEU A  19
 None
 1.41A 1mx1B-2fw2A:
undetectable		 1mx1B-2fw2A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2fw2 TESTIS-SPECIFIC
CHROMODOMAIN PROTEIN
Y 2
(Homo
sapiens) 		3 / 3 ILE A   6
ILE A  17
THR A  21
 None
 0.54A 1rg7A-2fw2A:
undetectable		 1rg7A-2fw2A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 2fw2 TESTIS-SPECIFIC
CHROMODOMAIN PROTEIN
Y 2
(Homo
sapiens) 		5 / 8 ALA A  28
ILE A 112
GLY A 113
GLY A 115
ILE A 118
 None
 1.22A 1sguA-2fw2A:
undetectable		 1sguA-2fw2A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 2fw2 TESTIS-SPECIFIC
CHROMODOMAIN PROTEIN
Y 2
(Homo
sapiens) 		5 / 8 ALA A  28
ILE A 112
GLY A 113
ILE A 118
ALA A  56
 None
 1.23A 1sguA-2fw2A:
undetectable		 1sguA-2fw2A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 2fw2 TESTIS-SPECIFIC
CHROMODOMAIN PROTEIN
Y 2
(Homo
sapiens) 		5 / 11 GLY A 109
MET A 164
LEU A 171
ALA A 173
ALA A 176
 None
 1.01A 1x7pA-2fw2A:
undetectable
1x7pB-2fw2A:
undetectable		 1x7pA-2fw2A:
20.40
1x7pB-2fw2A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 2fw2 TESTIS-SPECIFIC
CHROMODOMAIN PROTEIN
Y 2
(Homo
sapiens) 		4 / 5 ASN A 128
PHE A 191
VAL A 182
ALA A 173
 None
 1.21A 2cizA-2fw2A:
undetectable		 2cizA-2fw2A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_2
(PROTEASE
(RETROPEPSIN))		 2fw2 TESTIS-SPECIFIC
CHROMODOMAIN PROTEIN
Y 2
(Homo
sapiens) 		5 / 12 ASN A 108
GLY A 109
VAL A 105
GLY A 115
VAL A  18
 None
 0.87A 3bvbB-2fw2A:
undetectable		 3bvbB-2fw2A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2fw2 TESTIS-SPECIFIC
CHROMODOMAIN PROTEIN
Y 2
(Homo
sapiens) 		5 / 12 ILE A   6
ALA A  56
ILE A 103
LEU A  41
ILE A  17
 None
 1.06A 3drcB-2fw2A:
undetectable		 3drcB-2fw2A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)		 2fw2 TESTIS-SPECIFIC
CHROMODOMAIN PROTEIN
Y 2
(Homo
sapiens) 		5 / 12 LEU A  19
ASN A 108
VAL A 107
VAL A  60
GLY A 109
 None
 1.30A 3medA-2fw2A:
undetectable
3medB-2fw2A:
undetectable		 3medA-2fw2A:
19.29
3medB-2fw2A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_A_NCAA192_0
(NICOTINAMIDASE)		 2fw2 TESTIS-SPECIFIC
CHROMODOMAIN PROTEIN
Y 2
(Homo
sapiens) 		5 / 11 ASP A 145
PHE A  92
LEU A 121
ILE A 118
SER A 117
 None
 1.06A 3o94A-2fw2A:
undetectable		 3o94A-2fw2A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_B_NCAB192_0
(NICOTINAMIDASE)		 2fw2 TESTIS-SPECIFIC
CHROMODOMAIN PROTEIN
Y 2
(Homo
sapiens) 		5 / 11 ASP A 145
PHE A  92
LEU A 121
ILE A 118
SER A 117
 None
 1.07A 3o94B-2fw2A:
undetectable		 3o94B-2fw2A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_C_NCAC192_0
(NICOTINAMIDASE)		 2fw2 TESTIS-SPECIFIC
CHROMODOMAIN PROTEIN
Y 2
(Homo
sapiens) 		5 / 11 ASP A 145
PHE A  92
LEU A 121
ILE A 118
SER A 117
 None
 1.04A 3o94C-2fw2A:
undetectable		 3o94C-2fw2A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_D_NCAD192_0
(NICOTINAMIDASE)		 2fw2 TESTIS-SPECIFIC
CHROMODOMAIN PROTEIN
Y 2
(Homo
sapiens) 		5 / 11 ASP A 145
PHE A  92
LEU A 121
ILE A 118
SER A 117
 None
 1.04A 3o94D-2fw2A:
undetectable		 3o94D-2fw2A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_2
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2fw2 TESTIS-SPECIFIC
CHROMODOMAIN PROTEIN
Y 2
(Homo
sapiens) 		4 / 5 VAL A  38
PHE A  54
ILE A 118
PHE A  61
 None
 1.02A 3owxB-2fw2A:
undetectable		 3owxB-2fw2A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 2fw2 TESTIS-SPECIFIC
CHROMODOMAIN PROTEIN
Y 2
(Homo
sapiens) 		3 / 3 ASN A  27
LEU A 119
PHE A 260
 None
 0.82A 4dajB-2fw2A:
1.1		 4dajB-2fw2A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 2fw2 TESTIS-SPECIFIC
CHROMODOMAIN PROTEIN
Y 2
(Homo
sapiens) 		5 / 12 ILE A   6
ALA A  56
ILE A 103
LEU A  41
ILE A  17
 None
 1.06A 4dfrB-2fw2A:
undetectable		 4dfrB-2fw2A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2fw2 TESTIS-SPECIFIC
CHROMODOMAIN PROTEIN
Y 2
(Homo
sapiens) 		3 / 3 TYR A  69
HIS A  73
ARG A  72
 None
 0.98A 4e7bC-2fw2A:
1.0		 4e7bC-2fw2A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2fw2 TESTIS-SPECIFIC
CHROMODOMAIN PROTEIN
Y 2
(Homo
sapiens) 		5 / 12 GLY A  64
VAL A  38
PHE A  54
ILE A 118
PHE A  61
 None
 1.00A 4fglA-2fw2A:
undetectable
4fglB-2fw2A:
undetectable		 4fglA-2fw2A:
22.91
4fglB-2fw2A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_2
(PROTEASE PR5-DRV)		 2fw2 TESTIS-SPECIFIC
CHROMODOMAIN PROTEIN
Y 2
(Homo
sapiens) 		4 / 8 ASN A 108
GLY A 109
VAL A 105
GLY A 115
 None
 0.57A 5kr1B-2fw2A:
undetectable		 5kr1B-2fw2A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 2fw2 TESTIS-SPECIFIC
CHROMODOMAIN PROTEIN
Y 2
(Homo
sapiens) 		4 / 8 LYS A 214
ALA A 215
ASP A 123
ASN A 206
 None
 0.88A 5mvsB-2fw2A:
undetectable		 5mvsB-2fw2A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)		 2fw2 TESTIS-SPECIFIC
CHROMODOMAIN PROTEIN
Y 2
(Homo
sapiens) 		5 / 12 LEU A 114
ALA A 116
LEU A 119
LEU A 121
ILE A  34
 None
 1.04A 5toaA-2fw2A:
undetectable		 5toaA-2fw2A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 2fw2 TESTIS-SPECIFIC
CHROMODOMAIN PROTEIN
Y 2
(Homo
sapiens) 		3 / 3 ASP A   5
ARG A   4
ASP A  66
 None
 0.84A 5zvgA-2fw2A:
undetectable		 5zvgA-2fw2A:
24.44