SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fwm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 2fwm 2,3-DIHYDRO-2,3-DIHY
DROXYBENZOATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 THR X  11
GLY X 105
ALA X 107
THR X  99
GLU X  94
 None
 1.25A 1vq1A-2fwmX:
5.6		 1vq1A-2fwmX:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 2fwm 2,3-DIHYDRO-2,3-DIHY
DROXYBENZOATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 THR X  11
ILE X  82
ALA X 107
THR X  99
GLU X  94
 None
 1.23A 1vq1A-2fwmX:
5.6		 1vq1A-2fwmX:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2fwm 2,3-DIHYDRO-2,3-DIHY
DROXYBENZOATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 5 GLN X 113
THR X 114
THR X 128
LEU X 154
 None
 1.37A 3ce6A-2fwmX:
7.9		 3ce6A-2fwmX:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2fwm 2,3-DIHYDRO-2,3-DIHY
DROXYBENZOATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 5 GLN X 113
THR X 114
THR X 128
LEU X 154
 None
 1.36A 3ce6C-2fwmX:
8.2		 3ce6C-2fwmX:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 2fwm 2,3-DIHYDRO-2,3-DIHY
DROXYBENZOATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY X  12
GLY X  14
ALA X  20
VAL X  53
VAL X 102
 None
 1.12A 3dmhA-2fwmX:
7.2		 3dmhA-2fwmX:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)		 2fwm 2,3-DIHYDRO-2,3-DIHY
DROXYBENZOATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 6 ASP X  52
GLY X 106
VAL X 102
THR X  11
 None
 1.07A 3vqrA-2fwmX:
4.4		 3vqrA-2fwmX:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 2fwm 2,3-DIHYDRO-2,3-DIHY
DROXYBENZOATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 5 ASP X  52
GLY X 106
VAL X 102
THR X  11
 None
 1.08A 3vqrB-2fwmX:
6.3		 3vqrB-2fwmX:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2fwm 2,3-DIHYDRO-2,3-DIHY
DROXYBENZOATE
DEHYDROGENASE
(Escherichia
coli) 		6 / 12 ALA X  30
ILE X 126
VAL X   8
ALA X  24
LEU X 223
ALA X 226
 None
 1.25A 4tyjA-2fwmX:
undetectable		 4tyjA-2fwmX:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 2fwm 2,3-DIHYDRO-2,3-DIHY
DROXYBENZOATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 8 VAL X 172
ILE X 218
ALA X 219
VAL X  77
VAL X 127
 None
 0.87A 5l94A-2fwmX:
undetectable		 5l94A-2fwmX:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 2fwm 2,3-DIHYDRO-2,3-DIHY
DROXYBENZOATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 5 SER X 142
ALA X 143
GLN X  97
THR X  99
 None
 1.39A 5n0tA-2fwmX:
2.0		 5n0tA-2fwmX:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 2fwm 2,3-DIHYDRO-2,3-DIHY
DROXYBENZOATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 LEU X  76
ALA X  75
VAL X   8
ILE X 218
ALA X  79
 None
 1.15A 5n5dB-2fwmX:
2.9		 5n5dB-2fwmX:
24.82