SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fwr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 2fwr DNA REPAIR PROTEIN
RAD25
(Archaeoglobus
fulgidus) 		3 / 3 VAL A 246
VAL A 114
TRP A 105
 None
 0.92A 1bdwA-2fwrA:
undetectable
1bdwB-2fwrA:
undetectable		 1bdwA-2fwrA:
3.40
1bdwB-2fwrA:
3.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 2fwr DNA REPAIR PROTEIN
RAD25
(Archaeoglobus
fulgidus) 		4 / 8 ARG A 327
ALA A 309
GLY A 294
ILE A 295
 None
 0.70A 1hshD-2fwrA:
undetectable		 1hshD-2fwrA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_C_BEZC505_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2fwr DNA REPAIR PROTEIN
RAD25
(Archaeoglobus
fulgidus) 		4 / 6 ILE A  65
GLU A  66
PHE A 220
ARG A 298
 None
 1.25A 1oniA-2fwrA:
undetectable
1oniC-2fwrA:
undetectable		 1oniA-2fwrA:
16.45
1oniC-2fwrA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 2fwr DNA REPAIR PROTEIN
RAD25
(Archaeoglobus
fulgidus) 		4 / 6 LEU A 271
TYR A 279
ILE A 329
GLY A 423
 None
 0.95A 2du8A-2fwrA:
undetectable		 2du8A-2fwrA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EFJ_A_37TA502_1
(3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE)		 2fwr DNA REPAIR PROTEIN
RAD25
(Archaeoglobus
fulgidus) 		5 / 12 LEU A 102
ILE A 429
SER A 424
ILE A 418
ILE A 451
 None
 1.38A 2efjA-2fwrA:
undetectable		 2efjA-2fwrA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 2fwr DNA REPAIR PROTEIN
RAD25
(Archaeoglobus
fulgidus) 		5 / 12 ARG A 266
ILE A 129
ILE A 197
ALA A 101
GLU A  99
 None
 1.18A 2j0dA-2fwrA:
undetectable		 2j0dA-2fwrA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 2fwr DNA REPAIR PROTEIN
RAD25
(Archaeoglobus
fulgidus) 		4 / 4 LEU A 447
THR A 263
ILE A 352
HIS A 347
 None
 1.41A 2jfaB-2fwrA:
undetectable		 2jfaB-2fwrA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 2fwr DNA REPAIR PROTEIN
RAD25
(Archaeoglobus
fulgidus) 		3 / 3 ARG A 431
GLU A 427
GLN A 430
 None
 1.00A 2p16A-2fwrA:
undetectable		 2p16A-2fwrA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2fwr DNA REPAIR PROTEIN
RAD25
(Archaeoglobus
fulgidus) 		3 / 3 ILE A 217
ILE A  64
LEU A 132
 None
 0.55A 2prgA-2fwrA:
undetectable		 2prgA-2fwrA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 2fwr DNA REPAIR PROTEIN
RAD25
(Archaeoglobus
fulgidus) 		3 / 3 PHE A 198
SER A 216
LEU A 189
 None
 0.75A 2w1bA-2fwrA:
undetectable		 2w1bA-2fwrA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 2fwr DNA REPAIR PROTEIN
RAD25
(Archaeoglobus
fulgidus) 		4 / 7 GLY A 162
ILE A  83
THR A  85
LEU A 174
 None
 0.98A 2xrhA-2fwrA:
undetectable		 2xrhA-2fwrA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2fwr DNA REPAIR PROTEIN
RAD25
(Archaeoglobus
fulgidus) 		4 / 8 GLY A 421
ILE A 343
VAL A 399
SER A 452
 None
 0.82A 2yoeB-2fwrA:
undetectable
2yoeC-2fwrA:
undetectable		 2yoeB-2fwrA:
21.33
2yoeC-2fwrA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 2fwr DNA REPAIR PROTEIN
RAD25
(Archaeoglobus
fulgidus) 		3 / 3 PRO A 251
LEU A 254
ARG A  95
 None
 0.82A 3aqiA-2fwrA:
3.3		 3aqiA-2fwrA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 2fwr DNA REPAIR PROTEIN
RAD25
(Archaeoglobus
fulgidus) 		3 / 3 TYR A 286
TYR A 279
GLU A 324
 None
 0.98A 3pfgA-2fwrA:
3.5		 3pfgA-2fwrA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 2fwr DNA REPAIR PROTEIN
RAD25
(Archaeoglobus
fulgidus) 		4 / 7 ARG A 327
ALA A 309
GLY A 294
ILE A 295
 None
 0.70A 3spkB-2fwrA:
undetectable		 3spkB-2fwrA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_E_ACTE204_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 2fwr DNA REPAIR PROTEIN
RAD25
(Archaeoglobus
fulgidus) 		3 / 3 LYS A 172
PRO A 173
LEU A 174
 None
 0.51A 3tpxE-2fwrA:
undetectable		 3tpxE-2fwrA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 2fwr DNA REPAIR PROTEIN
RAD25
(Archaeoglobus
fulgidus) 		4 / 6 GLY A 456
LEU A 271
TYR A 279
GLU A 283
 None
 1.15A 3w9tB-2fwrA:
undetectable		 3w9tB-2fwrA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 2fwr DNA REPAIR PROTEIN
RAD25
(Archaeoglobus
fulgidus) 		4 / 6 GLY A 456
LEU A 271
TYR A 279
GLU A 283
 None
 1.14A 3w9tE-2fwrA:
undetectable		 3w9tE-2fwrA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 2fwr DNA REPAIR PROTEIN
RAD25
(Archaeoglobus
fulgidus) 		4 / 6 GLY A 456
LEU A 271
TYR A 279
GLU A 283
 None
 1.16A 3w9tF-2fwrA:
undetectable		 3w9tF-2fwrA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 2fwr DNA REPAIR PROTEIN
RAD25
(Archaeoglobus
fulgidus) 		5 / 12 LEU A 132
PRO A 135
ALA A  80
LEU A 196
GLY A 111
 None
 0.96A 4l9qB-2fwrA:
undetectable		 4l9qB-2fwrA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_2
(ANDROGEN RECEPTOR)		 2fwr DNA REPAIR PROTEIN
RAD25
(Archaeoglobus
fulgidus) 		4 / 7 LEU A 196
LEU A 224
LEU A 204
ILE A 113
 None
 1.04A 4okwA-2fwrA:
undetectable		 4okwA-2fwrA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 2fwr DNA REPAIR PROTEIN
RAD25
(Archaeoglobus
fulgidus) 		5 / 9 PHE A 193
GLY A 190
GLU A 187
ILE A 217
ALA A 218
 None
 1.43A 5entC-2fwrA:
0.0		 5entC-2fwrA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 2fwr DNA REPAIR PROTEIN
RAD25
(Archaeoglobus
fulgidus) 		3 / 3 ASP A 180
SER A 208
TYR A 209
 None
 0.89A 5glmA-2fwrA:
undetectable		 5glmA-2fwrA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 2fwr DNA REPAIR PROTEIN
RAD25
(Archaeoglobus
fulgidus) 		5 / 6 THR A 392
GLY A 389
GLU A 388
PHE A 390
ILE A 374
 None
 1.29A 5kmfA-2fwrA:
undetectable
5kmfC-2fwrA:
undetectable		 5kmfA-2fwrA:
22.39
5kmfC-2fwrA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 2fwr DNA REPAIR PROTEIN
RAD25
(Archaeoglobus
fulgidus) 		3 / 3 MET A 126
GLU A 151
ARG A 152
 None
 1.12A 5tjyA-2fwrA:
undetectable		 5tjyA-2fwrA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2fwr DNA REPAIR PROTEIN
RAD25
(Archaeoglobus
fulgidus) 		3 / 3 GLU A 200
HIS A 203
ARG A 230
 None
None
IPA  A6001 (-3.0A)
 0.82A 5uunA-2fwrA:
undetectable		 5uunA-2fwrA:
21.31