SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fwv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 2fwv HYPOTHETICAL PROTEIN
MTUBF_01000852
(Mycobacterium
tuberculosis) 		5 / 10 GLU A 157
ARG A 190
LEU A 149
GLU A 126
GLY A 182
 None
DIO  A 501 (-3.7A)
None
DIO  A 501 (-3.2A)
None
 1.16A 1cmcA-2fwvA:
undetectable
1cmcB-2fwvA:
undetectable		 1cmcA-2fwvA:
18.85
1cmcB-2fwvA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 2fwv HYPOTHETICAL PROTEIN
MTUBF_01000852
(Mycobacterium
tuberculosis) 		4 / 5 ARG A  82
ARG A  89
GLY A  79
GLU A  78
 None
 0.94A 4z3oA-2fwvA:
undetectable
4z3oB-2fwvA:
undetectable		 4z3oA-2fwvA:
15.64
4z3oB-2fwvA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2fwv HYPOTHETICAL PROTEIN
MTUBF_01000852
(Mycobacterium
tuberculosis) 		4 / 7 ARG A  82
ARG A  89
GLY A  79
GLU A  78
 None
 0.86A 5bs8A-2fwvA:
undetectable
5bs8C-2fwvA:
undetectable
5bs8D-2fwvA:
undetectable		 5bs8A-2fwvA:
19.28
5bs8C-2fwvA:
19.28
5bs8D-2fwvA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 2fwv HYPOTHETICAL PROTEIN
MTUBF_01000852
(Mycobacterium
tuberculosis) 		4 / 7 ARG A  89
GLY A  79
GLU A  78
ARG A  82
 None
 0.83A 5bs8A-2fwvA:
undetectable
5bs8B-2fwvA:
undetectable
5bs8C-2fwvA:
undetectable		 5bs8A-2fwvA:
19.28
5bs8B-2fwvA:
25.00
5bs8C-2fwvA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2fwv HYPOTHETICAL PROTEIN
MTUBF_01000852
(Mycobacterium
tuberculosis) 		4 / 7 ARG A  82
ARG A  89
GLY A  79
GLU A  78
 None
 0.86A 5btaA-2fwvA:
undetectable
5btaC-2fwvA:
undetectable
5btaD-2fwvA:
undetectable		 5btaA-2fwvA:
19.28
5btaC-2fwvA:
19.28
5btaD-2fwvA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 2fwv HYPOTHETICAL PROTEIN
MTUBF_01000852
(Mycobacterium
tuberculosis) 		4 / 6 ARG A  89
GLY A  79
GLU A  78
ARG A  82
 None
 0.84A 5btaA-2fwvA:
undetectable
5btaB-2fwvA:
undetectable
5btaC-2fwvA:
undetectable		 5btaA-2fwvA:
19.28
5btaB-2fwvA:
25.00
5btaC-2fwvA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2fwv HYPOTHETICAL PROTEIN
MTUBF_01000852
(Mycobacterium
tuberculosis) 		4 / 6 ARG A  82
ARG A  89
GLY A  79
GLU A  78
 None
 0.85A 5btcA-2fwvA:
undetectable
5btcC-2fwvA:
undetectable
5btcD-2fwvA:
undetectable		 5btcA-2fwvA:
19.28
5btcC-2fwvA:
19.28
5btcD-2fwvA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2fwv HYPOTHETICAL PROTEIN
MTUBF_01000852
(Mycobacterium
tuberculosis) 		4 / 6 ARG A  89
GLY A  79
GLU A  78
ARG A  82
 None
 0.83A 5btcA-2fwvA:
undetectable
5btcB-2fwvA:
undetectable
5btcC-2fwvA:
undetectable		 5btcA-2fwvA:
19.28
5btcB-2fwvA:
25.00
5btcC-2fwvA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 2fwv HYPOTHETICAL PROTEIN
MTUBF_01000852
(Mycobacterium
tuberculosis) 		4 / 7 ARG A  89
GLY A  79
GLU A  78
ARG A  82
 None
 0.86A 5btdA-2fwvA:
undetectable
5btdB-2fwvA:
undetectable
5btdC-2fwvA:
undetectable		 5btdA-2fwvA:
19.28
5btdB-2fwvA:
25.00
5btdC-2fwvA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2fwv HYPOTHETICAL PROTEIN
MTUBF_01000852
(Mycobacterium
tuberculosis) 		4 / 7 ARG A  89
GLY A  79
GLU A  78
ARG A  82
 None
 0.86A 5btfA-2fwvA:
undetectable
5btfB-2fwvA:
undetectable
5btfC-2fwvA:
undetectable		 5btfA-2fwvA:
19.28
5btfB-2fwvA:
25.00
5btfC-2fwvA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 2fwv HYPOTHETICAL PROTEIN
MTUBF_01000852
(Mycobacterium
tuberculosis) 		4 / 6 ARG A  89
GLY A  79
GLU A  78
ARG A  82
 None
 0.85A 5btgA-2fwvA:
undetectable
5btgB-2fwvA:
undetectable
5btgC-2fwvA:
undetectable		 5btgA-2fwvA:
19.28
5btgB-2fwvA:
25.00
5btgC-2fwvA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2fwv HYPOTHETICAL PROTEIN
MTUBF_01000852
(Mycobacterium
tuberculosis) 		4 / 5 ARG A  89
GLY A  79
GLU A  78
ARG A  82
 None
 0.93A 5cdqA-2fwvA:
undetectable
5cdqB-2fwvA:
undetectable
5cdqC-2fwvA:
undetectable		 5cdqA-2fwvA:
19.96
5cdqB-2fwvA:
22.32
5cdqC-2fwvA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2fwv HYPOTHETICAL PROTEIN
MTUBF_01000852
(Mycobacterium
tuberculosis) 		4 / 5 ARG A  89
GLY A  79
GLU A  78
ARG A  82
 None
 0.94A 5cdqR-2fwvA:
undetectable
5cdqS-2fwvA:
undetectable
5cdqT-2fwvA:
undetectable		 5cdqR-2fwvA:
19.96
5cdqS-2fwvA:
22.32
5cdqT-2fwvA:
19.96