SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fx5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 2fx5 LIPASE
(Pseudomonas
mendocina) 		4 / 4 GLY A  57
SER A 126
ILE A 178
HIS A 206
 None
 1.17A 1yajJ-2fx5A:
12.9		 1yajJ-2fx5A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 2fx5 LIPASE
(Pseudomonas
mendocina) 		5 / 12 ALA A   9
TYR A  23
LYS A 114
PRO A  50
GLY A  76
 None
 1.32A 2nv4B-2fx5A:
undetectable		 2nv4B-2fx5A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		 2fx5 LIPASE
(Pseudomonas
mendocina) 		3 / 3 LEU A 100
TYR A 111
GLY A 109
 None
 0.47A 2ocuA-2fx5A:
undetectable		 2ocuA-2fx5A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 2fx5 LIPASE
(Pseudomonas
mendocina) 		5 / 12 GLN A 127
ASN A  56
GLY A 124
GLY A  55
ASN A 184
 None
 1.18A 2zw9A-2fx5A:
2.0		 2zw9A-2fx5A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC32_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2fx5 LIPASE
(Pseudomonas
mendocina) 		5 / 6 GLY A 124
GLY A 128
GLY A 131
GLY A  55
GLY A  88
 None
 1.19A 3bogA-2fx5A:
undetectable
3bogC-2fx5A:
0.0		 3bogA-2fx5A:
undetectable
3bogC-2fx5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2fx5 LIPASE
(Pseudomonas
mendocina) 		4 / 4 GLY A  88
GLY A 128
GLY A  55
GLY A 131
 None
 0.67A 3bogC-2fx5A:
undetectable		 3bogC-2fx5A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID32_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2fx5 LIPASE
(Pseudomonas
mendocina) 		5 / 6 GLY A 124
GLY A 128
GLY A 131
GLY A  55
GLY A  90
 None
 0.86A 3bogB-2fx5A:
0.0
3bogD-2fx5A:
0.0		 3bogB-2fx5A:
undetectable
3bogD-2fx5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2fx5 LIPASE
(Pseudomonas
mendocina) 		4 / 4 GLY A  88
GLY A 128
GLY A  55
GLY A 131
 None
 0.65A 3bogD-2fx5A:
undetectable		 3bogD-2fx5A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2fx5 LIPASE
(Pseudomonas
mendocina) 		4 / 4 GLY A 124
GLY A 128
GLY A 131
GLY A  55
 None
 0.67A 3bogD-2fx5A:
undetectable		 3bogD-2fx5A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB0_A_DIFA701_1
(LACTOTRANSFERRIN)		 2fx5 LIPASE
(Pseudomonas
mendocina) 		4 / 4 PRO A 107
TYR A 108
GLY A 109
THR A 110
 None
 1.24A 3ib0A-2fx5A:
undetectable		 3ib0A-2fx5A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2fx5 LIPASE
(Pseudomonas
mendocina) 		5 / 12 GLY A 131
PRO A 149
GLY A 155
ALA A 135
GLY A 136
 None
 0.89A 3ku1A-2fx5A:
undetectable		 3ku1A-2fx5A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2fx5 LIPASE
(Pseudomonas
mendocina) 		5 / 12 GLY A 131
PRO A 149
GLY A 155
ALA A 135
GLY A 136
 None
 0.90A 3ku1C-2fx5A:
2.7		 3ku1C-2fx5A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 2fx5 LIPASE
(Pseudomonas
mendocina) 		5 / 8 GLY A  90
GLY A 131
MET A 134
GLY A 136
VAL A 141
 None
 1.34A 3v1nA-2fx5A:
15.0		 3v1nA-2fx5A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_2
(NEURAMINIDASE)		 2fx5 LIPASE
(Pseudomonas
mendocina) 		3 / 3 ARG A 201
ARG A 202
TRP A 251
 None
 1.34A 4b7nA-2fx5A:
undetectable		 4b7nA-2fx5A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BB2_B_STRB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2fx5 LIPASE
(Pseudomonas
mendocina) 		5 / 11 ALA A  87
GLN A 164
THR A 144
ARG A  91
SER A 160
 None
 1.21A 4bb2A-2fx5A:
undetectable
4bb2B-2fx5A:
undetectable		 4bb2A-2fx5A:
20.29
4bb2B-2fx5A:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)		 2fx5 LIPASE
(Pseudomonas
mendocina) 		3 / 3 ARG A 201
ARG A 202
TRP A 251
 None
 1.34A 4cpzC-2fx5A:
undetectable		 4cpzC-2fx5A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_2
(NEURAMINIDASE)		 2fx5 LIPASE
(Pseudomonas
mendocina) 		3 / 3 ARG A 201
ARG A 202
TRP A 251
 None
 1.38A 4cpzE-2fx5A:
undetectable		 4cpzE-2fx5A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_2
(NEURAMINIDASE)		 2fx5 LIPASE
(Pseudomonas
mendocina) 		3 / 3 ARG A 201
ARG A 202
TRP A 251
 None
 1.33A 4cpzF-2fx5A:
undetectable		 4cpzF-2fx5A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_2
(NEURAMINIDASE)		 2fx5 LIPASE
(Pseudomonas
mendocina) 		3 / 3 ARG A 201
ARG A 202
TRP A 251
 None
 1.42A 4cpzG-2fx5A:
undetectable		 4cpzG-2fx5A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_2
(NEURAMINIDASE)		 2fx5 LIPASE
(Pseudomonas
mendocina) 		3 / 3 ARG A 201
ARG A 202
TRP A 251
 None
 1.33A 4cpzH-2fx5A:
undetectable		 4cpzH-2fx5A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2fx5 LIPASE
(Pseudomonas
mendocina) 		6 / 12 GLY A  55
GLY A 128
GLY A 131
LEU A  53
ALA A  81
HIS A 125
 None
 1.10A 4htfA-2fx5A:
undetectable		 4htfA-2fx5A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2fx5 LIPASE
(Pseudomonas
mendocina) 		6 / 12 GLY A  55
GLY A 128
GLY A 131
LEU A  53
ALA A  81
HIS A 125
 None
 1.10A 4htfB-2fx5A:
2.8		 4htfB-2fx5A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2fx5 LIPASE
(Pseudomonas
mendocina) 		4 / 7 SER A 252
TRP A 251
PHE A 197
GLU A 200
 None
 1.41A 6av7A-2fx5A:
undetectable
6av7B-2fx5A:
undetectable		 6av7A-2fx5A:
20.86
6av7B-2fx5A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 2fx5 LIPASE
(Pseudomonas
mendocina) 		4 / 8 VAL A  51
GLY A 129
SER A 132
ALA A 135
 None
 0.71A 6hu9H-2fx5A:
undetectable
6hu9e-2fx5A:
undetectable		 6hu9H-2fx5A:
14.29
6hu9e-2fx5A:
19.37