SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fxf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2fxf DIAMINE
ACETYLTRANSFERASE 1
(Homo
sapiens) 		5 / 9 ALA A   9
ASP A  13
ILE A 105
ILE A   6
THR A  10
 None
None
ACO  A1000 (-4.2A)
None
None
 1.38A 1j3jB-2fxfA:
undetectable		 1j3jB-2fxfA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2fxf DIAMINE
ACETYLTRANSFERASE 1
(Homo
sapiens) 		4 / 8 SER A 136
GLY A  73
ILE A 105
PHE A 103
 ACO  A1000 (-2.6A)
None
ACO  A1000 (-4.2A)
None
 0.95A 3aodA-2fxfA:
undetectable		 3aodA-2fxfA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P73_A_ACTA275_0
(MHC RFP-Y CLASS I
ALPHA CHAIN)		 2fxf DIAMINE
ACETYLTRANSFERASE 1
(Homo
sapiens) 		3 / 3 ILE A  71
VAL A  56
ARG A   7
 None
 0.57A 3p73A-2fxfA:
undetectable		 3p73A-2fxfA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 2fxf DIAMINE
ACETYLTRANSFERASE 1
(Homo
sapiens) 		3 / 3 ASN A 133
SER A 136
ARG A 101
 ACO  A1000 ( 3.1A)
ACO  A1000 (-2.6A)
ACO  A1000 (-3.7A)
 0.72A 5b2qA-2fxfA:
undetectable		 5b2qA-2fxfA:
6.75