SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fxt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2fxt IMPORT INNER
MEMBRANE TRANSLOCASE
SUBUNIT TIM44
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 302
PHE A 422
GLY A 425
SER A 396
LEU A 394
 None
 1.23A 3n8xA-2fxtA:
undetectable		 3n8xA-2fxtA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 2fxt IMPORT INNER
MEMBRANE TRANSLOCASE
SUBUNIT TIM44
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 308
ASP A 309
PHE A 422
PHE A 317
GLN A 329
 None
 1.31A 4wh5A-2fxtA:
undetectable		 4wh5A-2fxtA:
18.78