SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fy1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TF1_A_ACTA191_0 (METHYL-ACCEPTING CHEMOTAXIS PROTEIN)	2fy1	RNA-BINDING MOTIF PROTEIN, Y CHROMOSOME, FAMILY 1 MEMBER A1 (Homo sapiens)	4 / 5	LYS A 9 THR A 54 ILE A 53 LEU A 38	A B 121 ( 4.1A) None None A B 121 ( 3.8A)	1.38A	3tf1A-2fy1A: undetectable	3tf1A-2fy1A: 19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NNA_A_BZMA301_0 (ISATIN HYDROLASE A)	2fy1	RNA-BINDING MOTIF PROTEIN, Y CHROMOSOME, FAMILY 1 MEMBER A1 (Homo sapiens)	5 / 12	ILE A 12 LEU A 24 GLY A 14 GLY A 49 HIS A 74	None None C B 119 ( 2.7A) C B 119 ( 4.8A) None	1.12A	5nnaA-2fy1A: undetectable	5nnaA-2fy1A: 19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NNA_B_BZMB301_0 (ISATIN HYDROLASE A)	2fy1	RNA-BINDING MOTIF PROTEIN, Y CHROMOSOME, FAMILY 1 MEMBER A1 (Homo sapiens)	5 / 12	ILE A 12 LEU A 24 GLY A 14 GLY A 49 HIS A 74	None None C B 119 ( 2.7A) C B 119 ( 4.8A) None	1.13A	5nnaB-2fy1A: undetectable	5nnaB-2fy1A: 19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NNA_C_BZMC301_0 (ISATIN HYDROLASE A)	2fy1	RNA-BINDING MOTIF PROTEIN, Y CHROMOSOME, FAMILY 1 MEMBER A1 (Homo sapiens)	5 / 12	ILE A 12 LEU A 24 GLY A 14 GLY A 49 HIS A 74	None None C B 119 ( 2.7A) C B 119 ( 4.8A) None	1.14A	5nnaC-2fy1A: undetectable	5nnaC-2fy1A: 19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NNA_D_BZMD301_0 (ISATIN HYDROLASE A)	2fy1	RNA-BINDING MOTIF PROTEIN, Y CHROMOSOME, FAMILY 1 MEMBER A1 (Homo sapiens)	5 / 12	ILE A 12 LEU A 24 GLY A 14 GLY A 49 HIS A 74	None None C B 119 ( 2.7A) C B 119 ( 4.8A) None	1.12A	5nnaD-2fy1A: undetectable	5nnaD-2fy1A: 19.43

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3TF1_A_ACTA191_0","METHYL-ACCEPTING CHEMOTAXIS PROTEIN","2fy1","RNA-BINDING MOTIF PROTEIN, Y CHROMOSOME, FAMILY 1 MEMBER A1","Homo sapiens",4,"LYS A   9;THR A  54;ILE A  53;LEU A  38","  A B 121 ( 4.1A);None;None;  A B 121 ( 3.8A)","1.38A","3tf1A-2fy1A:undetectable","3tf1A-2fy1A:19.27"],["5NNA_A_BZMA301_0","ISATIN HYDROLASE A","2fy1","RNA-BINDING MOTIF PROTEIN, Y CHROMOSOME, FAMILY 1 MEMBER A1","Homo sapiens",5,"ILE A  12;LEU A  24;GLY A  14;GLY A  49;HIS A  74","None;None;  C B 119 ( 2.7A);  C B 119 ( 4.8A);None","1.12A","5nnaA-2fy1A:undetectable","5nnaA-2fy1A:19.43"],["5NNA_B_BZMB301_0","ISATIN HYDROLASE A","2fy1","RNA-BINDING MOTIF PROTEIN, Y CHROMOSOME, FAMILY 1 MEMBER A1","Homo sapiens",5,"ILE A  12;LEU A  24;GLY A  14;GLY A  49;HIS A  74","None;None;  C B 119 ( 2.7A);  C B 119 ( 4.8A);None","1.13A","5nnaB-2fy1A:undetectable","5nnaB-2fy1A:19.43"],["5NNA_C_BZMC301_0","ISATIN HYDROLASE A","2fy1","RNA-BINDING MOTIF PROTEIN, Y CHROMOSOME, FAMILY 1 MEMBER A1","Homo sapiens",5,"ILE A  12;LEU A  24;GLY A  14;GLY A  49;HIS A  74","None;None;  C B 119 ( 2.7A);  C B 119 ( 4.8A);None","1.14A","5nnaC-2fy1A:undetectable","5nnaC-2fy1A:19.43"],["5NNA_D_BZMD301_0","ISATIN HYDROLASE A","2fy1","RNA-BINDING MOTIF PROTEIN, Y CHROMOSOME, FAMILY 1 MEMBER A1","Homo sapiens",5,"ILE A  12;LEU A  24;GLY A  14;GLY A  49;HIS A  74","None;None;  C B 119 ( 2.7A);  C B 119 ( 4.8A);None","1.12A","5nnaD-2fy1A:undetectable","5nnaD-2fy1A:19.43"]]