SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fy2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2fy2 CHOLINE
O-ACETYLTRANSFERASE
(Homo
sapiens) 		5 / 12 LEU A 506
LEU A  21
GLY A  58
MET A 523
PHE A 524
 None
 1.34A 1d4fA-2fy2A:
undetectable		 1d4fA-2fy2A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2fy2 CHOLINE
O-ACETYLTRANSFERASE
(Homo
sapiens) 		5 / 12 LEU A 506
LEU A  21
GLY A  52
MET A 523
PHE A 524
 None
 1.45A 1d4fB-2fy2A:
undetectable		 1d4fB-2fy2A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 2fy2 CHOLINE
O-ACETYLTRANSFERASE
(Homo
sapiens) 		4 / 7 SER A 540
CYH A 574
ASN A 565
TYR A 564
 None
 0.90A 1dssG-2fy2A:
undetectable		 1dssG-2fy2A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 2fy2 CHOLINE
O-ACETYLTRANSFERASE
(Homo
sapiens) 		4 / 8 SER A 540
CYH A 574
ASN A 565
TYR A 564
 None
 0.89A 1dssR-2fy2A:
undetectable		 1dssR-2fy2A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 2fy2 CHOLINE
O-ACETYLTRANSFERASE
(Homo
sapiens) 		4 / 7 ARG A 430
THR A 467
VAL A 466
ALA A 592
 None
 1.08A 1fo4B-2fy2A:
undetectable		 1fo4B-2fy2A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_B_ESTB600_1
(OESTROGEN RECEPTOR)		 2fy2 CHOLINE
O-ACETYLTRANSFERASE
(Homo
sapiens) 		5 / 9 LEU A 164
GLU A 264
LEU A 260
HIS A 376
LEU A 235
 None
 1.50A 1gwrB-2fy2A:
0.3		 1gwrB-2fy2A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2fy2 CHOLINE
O-ACETYLTRANSFERASE
(Homo
sapiens) 		5 / 12 GLY A 123
ALA A 118
SER A 119
MET A 343
LEU A 272
 None
 1.31A 1kiaD-2fy2A:
undetectable		 1kiaD-2fy2A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B9E_A_SAMA1201_0
(NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2)		 2fy2 CHOLINE
O-ACETYLTRANSFERASE
(Homo
sapiens) 		5 / 12 CYH A 322
ASN A  95
ASP A 305
SER A 325
PHE A 327
 None
 1.16A 2b9eA-2fy2A:
2.1		 2b9eA-2fy2A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 2fy2 CHOLINE
O-ACETYLTRANSFERASE
(Homo
sapiens) 		5 / 10 ILE A 575
LEU A 572
ALA A 562
VAL A 593
ILE A 571
 None
 1.06A 2nnjA-2fy2A:
undetectable		 2nnjA-2fy2A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 2fy2 CHOLINE
O-ACETYLTRANSFERASE
(Homo
sapiens) 		5 / 12 LEU A 260
ILE A 263
VAL A 249
THR A 236
PHE A 194
 None
 1.31A 2qo4A-2fy2A:
undetectable		 2qo4A-2fy2A:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 2fy2 CHOLINE
O-ACETYLTRANSFERASE
(Homo
sapiens) 		5 / 12 LEU A 260
ILE A 263
VAL A 249
THR A 236
PHE A 194
 None
 1.31A 2qo6A-2fy2A:
undetectable		 2qo6A-2fy2A:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_GLYA502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2fy2 CHOLINE
O-ACETYLTRANSFERASE
(Homo
sapiens) 		4 / 7 SER A 532
ARG A 453
TYR A 529
TYR A  28
 None
 1.45A 2vmyA-2fy2A:
undetectable
2vmyB-2fy2A:
undetectable		 2vmyA-2fy2A:
21.01
2vmyB-2fy2A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 2fy2 CHOLINE
O-ACETYLTRANSFERASE
(Homo
sapiens) 		4 / 9 PHE A 589
ALA A 590
VAL A 593
GLU A 594
 None
 0.72A 2vufA-2fy2A:
undetectable		 2vufA-2fy2A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2fy2 CHOLINE
O-ACETYLTRANSFERASE
(Homo
sapiens) 		5 / 12 ILE A 406
SER A 596
ALA A 592
LEU A 421
ILE A 571
 None
 1.28A 3adsB-2fy2A:
undetectable		 3adsB-2fy2A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		 2fy2 CHOLINE
O-ACETYLTRANSFERASE
(Homo
sapiens) 		5 / 12 GLY A 292
SER A 237
THR A 236
VAL A 321
ALA A 300
 None
 1.25A 3d91B-2fy2A:
undetectable		 3d91B-2fy2A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 2fy2 CHOLINE
O-ACETYLTRANSFERASE
(Homo
sapiens) 		4 / 8 SER A 540
CYH A 574
ASN A 565
TYR A 564
 None
 0.90A 3dmtC-2fy2A:
undetectable		 3dmtC-2fy2A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 2fy2 CHOLINE
O-ACETYLTRANSFERASE
(Homo
sapiens) 		4 / 8 LEU A 172
ARG A 448
VAL A 331
GLY A 157
 None
 0.86A 4eq4B-2fy2A:
undetectable		 4eq4B-2fy2A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 2fy2 CHOLINE
O-ACETYLTRANSFERASE
(Homo
sapiens) 		4 / 7 ARG A 285
GLY A 316
ASN A 298
MET A 343
 None
 1.08A 4g0vA-2fy2A:
undetectable		 4g0vA-2fy2A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 2fy2 CHOLINE
O-ACETYLTRANSFERASE
(Homo
sapiens) 		4 / 6 ARG A 285
GLY A 316
ASN A 298
MET A 343
 None
 1.12A 4g0vB-2fy2A:
undetectable		 4g0vB-2fy2A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)		 2fy2 CHOLINE
O-ACETYLTRANSFERASE
(Homo
sapiens) 		4 / 7 TYR A 127
PHE A 310
LEU A 158
PHE A 327
 None
 1.12A 4uymB-2fy2A:
undetectable		 4uymB-2fy2A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 2fy2 CHOLINE
O-ACETYLTRANSFERASE
(Homo
sapiens) 		5 / 12 LEU A 428
LEU A 421
ALA A 424
ALA A 562
ILE A 394
 None
 1.05A 4x20B-2fy2A:
undetectable		 4x20B-2fy2A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 2fy2 CHOLINE
O-ACETYLTRANSFERASE
(Homo
sapiens) 		5 / 12 TYR A 552
ASP A 414
LEU A 597
PHE A 573
ILE A 417
 None
 1.14A 5dv4A-2fy2A:
undetectable		 5dv4A-2fy2A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2fy2 CHOLINE
O-ACETYLTRANSFERASE
(Homo
sapiens) 		5 / 8 VAL A 593
ILE A 571
LEU A 597
ILE A 417
SER A 576
 None
 1.33A 5numA-2fy2A:
undetectable		 5numA-2fy2A:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 2fy2 CHOLINE
O-ACETYLTRANSFERASE
(Homo
sapiens) 		4 / 6 THR A 171
ASP A 170
LEU A 164
ASP A 305
 None
 1.19A 5tdzA-2fy2A:
undetectable		 5tdzA-2fy2A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 2fy2 CHOLINE
O-ACETYLTRANSFERASE
(Homo
sapiens) 		3 / 3 ARG A 453
PRO A 434
TYR A 529
 None
 0.76A 5tzoB-2fy2A:
undetectable		 5tzoB-2fy2A:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2fy2 CHOLINE
O-ACETYLTRANSFERASE
(Homo
sapiens) 		4 / 4 LEU A 235
LEU A 234
SER A 379
ALA A 381
 None
 1.13A 5uunA-2fy2A:
undetectable		 5uunA-2fy2A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 2fy2 CHOLINE
O-ACETYLTRANSFERASE
(Homo
sapiens) 		3 / 3 GLY A 499
ASP A 450
ILE A 452
 None
 0.57A 6dgxB-2fy2A:
undetectable		 6dgxB-2fy2A:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_1
(-)		 2fy2 CHOLINE
O-ACETYLTRANSFERASE
(Homo
sapiens) 		5 / 12 LEU A 506
LEU A  21
GLY A  52
MET A 523
PHE A 524
 None
 1.49A 6gbnA-2fy2A:
undetectable		 6gbnA-2fy2A:
20.81