SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fyi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2fyi HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CBL
(Escherichia
coli) 		6 / 12 ILE A 145
LEU A 290
PHE A 287
ILE A 112
LEU A 124
ILE A  97
 None
 1.36A 1rb2A-2fyiA:
undetectable		 1rb2A-2fyiA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 2fyi HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CBL
(Escherichia
coli) 		4 / 6 LEU A 259
LEU A 170
ILE A 257
ARG A 258
 None
 0.90A 2rlfC-2fyiA:
undetectable
2rlfD-2fyiA:
undetectable		 2rlfC-2fyiA:
14.16
2rlfD-2fyiA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2fyi HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CBL
(Escherichia
coli) 		4 / 5 LEU A 184
THR A 261
THR A 179
HIS A 176
 None
 1.37A 3ce6B-2fyiA:
undetectable		 3ce6B-2fyiA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 2fyi HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CBL
(Escherichia
coli) 		4 / 8 ILE A 230
LEU A 222
THR A 202
GLY A 241
 None
 0.87A 3dcjB-2fyiA:
undetectable		 3dcjB-2fyiA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)		 2fyi HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CBL
(Escherichia
coli) 		3 / 3 ALA A 160
VAL A 159
GLN A 303
 None
 0.74A 3of4B-2fyiA:
undetectable		 3of4B-2fyiA:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 2fyi HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CBL
(Escherichia
coli) 		5 / 10 LEU A 242
LEU A 186
ILE A 189
ALA A 190
THR A 196
 None
 0.82A 3r9cA-2fyiA:
undetectable		 3r9cA-2fyiA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 2fyi HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CBL
(Escherichia
coli) 		5 / 9 ALA A  98
LEU A 108
LEU A 126
LEU A  95
ILE A 112
 None
 1.09A 3wdmC-2fyiA:
undetectable		 3wdmC-2fyiA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2fyi HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CBL
(Escherichia
coli) 		6 / 12 ILE A 145
LEU A 290
PHE A 287
ILE A 112
LEU A 124
ILE A  97
 None
 1.33A 4ej1A-2fyiA:
undetectable		 4ej1A-2fyiA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2fyi HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CBL
(Escherichia
coli) 		3 / 3 GLN A 128
THR A 100
THR A  99
 None
 0.82A 4fu9A-2fyiA:
undetectable		 4fu9A-2fyiA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUF_A_ACTA310_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2fyi HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CBL
(Escherichia
coli) 		3 / 3 GLN A 128
THR A 100
THR A  99
 None
 0.80A 4fufA-2fyiA:
undetectable		 4fufA-2fyiA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_B_ASCB304_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 2fyi HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CBL
(Escherichia
coli) 		4 / 6 PHE A 265
HIS A 168
ILE A 207
TYR A 197
 None
 1.50A 4o7gB-2fyiA:
undetectable		 4o7gB-2fyiA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2fyi HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CBL
(Escherichia
coli) 		4 / 8 SER A 182
LEU A 259
LEU A 170
VAL A 172
 None
 0.86A 4oj4A-2fyiA:
undetectable		 4oj4A-2fyiA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2fyi HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CBL
(Escherichia
coli) 		6 / 12 ILE A 145
LEU A 290
PHE A 287
ILE A 112
LEU A 124
ILE A  97
 None
 1.30A 5eajA-2fyiA:
undetectable		 5eajA-2fyiA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 2fyi HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CBL
(Escherichia
coli) 		3 / 3 PRO A 131
ARG A 151
GLU A 150
 None
 0.97A 5j6hA-2fyiA:
undetectable		 5j6hA-2fyiA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 2fyi HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CBL
(Escherichia
coli) 		5 / 12 ALA A  98
GLY A 129
LEU A  95
ALA A 148
GLY A 146
 None
 1.42A 5jglB-2fyiA:
undetectable		 5jglB-2fyiA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 2fyi HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CBL
(Escherichia
coli) 		4 / 8 SER A 107
THR A 102
THR A 202
SER A 149
 None
 1.01A 5l4eA-2fyiA:
undetectable
5l4eB-2fyiA:
undetectable
5l4eC-2fyiA:
undetectable
5l4eD-2fyiA:
undetectable
5l4eE-2fyiA:
undetectable		 5l4eA-2fyiA:
21.74
5l4eB-2fyiA:
21.74
5l4eC-2fyiA:
21.74
5l4eD-2fyiA:
21.74
5l4eE-2fyiA:
21.74