SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fym'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWH_A_PEMA501_1
(HEMOGLOBIN ALPHA
CHAIN)		 2fym ENOLASE
(Escherichia
coli) 		4 / 6 ALA A 353
LYS A 356
ASP A 360
ALA A 361
 None
 0.34A 1iwhA-2fymA:
undetectable		 1iwhA-2fymA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2fym ENOLASE
(Escherichia
coli) 		4 / 7 ALA A 181
TYR A 405
ILE A 170
PRO A 172
 None
 1.09A 1oniA-2fymA:
undetectable
1oniB-2fymA:
undetectable		 1oniA-2fymA:
17.80
1oniB-2fymA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2fym ENOLASE
(Escherichia
coli) 		4 / 6 ALA A 181
TYR A 405
ILE A 170
PRO A 172
 None
 1.07A 1oniB-2fymA:
undetectable
1oniC-2fymA:
undetectable		 1oniB-2fymA:
17.80
1oniC-2fymA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2fym ENOLASE
(Escherichia
coli) 		4 / 7 TYR A 405
ILE A 170
PRO A 172
ALA A 181
 None
 1.00A 1oniD-2fymA:
undetectable
1oniE-2fymA:
undetectable		 1oniD-2fymA:
17.80
1oniE-2fymA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2fym ENOLASE
(Escherichia
coli) 		4 / 6 ALA A 181
TYR A 405
ILE A 170
PRO A 172
 None
 1.08A 1oniH-2fymA:
undetectable
1oniI-2fymA:
undetectable		 1oniH-2fymA:
17.80
1oniI-2fymA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 2fym ENOLASE
(Escherichia
coli) 		3 / 3 ASP A 400
ARG A 398
ASP A  13
 None
 0.87A 1vptA-2fymA:
undetectable		 1vptA-2fymA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2fym ENOLASE
(Escherichia
coli) 		4 / 7 ARG A   9
ALA A 112
ASN A 108
ALA A  36
 None
 1.08A 2ejfA-2fymA:
undetectable		 2ejfA-2fymA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 2fym ENOLASE
(Escherichia
coli) 		4 / 8 VAL A  70
LEU A  26
GLY A  32
ALA A 120
 None
 0.92A 2xfsA-2fymA:
undetectable		 2xfsA-2fymA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 2fym ENOLASE
(Escherichia
coli) 		4 / 8 VAL A  70
LEU A  26
GLY A  32
ALA A 120
 None
 0.94A 2xh9A-2fymA:
undetectable		 2xh9A-2fymA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 2fym ENOLASE
(Escherichia
coli) 		4 / 8 LEU A 348
LEU A 115
THR A 323
GLY A 346
 None
 0.81A 3dcjB-2fymA:
undetectable		 3dcjB-2fymA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_1
(PROTEASE)		 2fym ENOLASE
(Escherichia
coli) 		5 / 8 GLY A 174
ALA A 175
VAL A 178
GLY A 185
ILE A 170
 None
 1.12A 3ekpA-2fymA:
undetectable		 3ekpA-2fymA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 2fym ENOLASE
(Escherichia
coli) 		5 / 12 SER A 371
HIS A 158
VAL A 205
GLY A 206
HIS A 369
 None
 1.27A 3f8wB-2fymA:
undetectable		 3f8wB-2fymA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 2fym ENOLASE
(Escherichia
coli) 		4 / 8 ALA A  22
ALA A  34
THR A 378
LEU A 129
 None
 0.98A 3khmA-2fymA:
undetectable		 3khmA-2fymA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2fym ENOLASE
(Escherichia
coli) 		4 / 5 ILE A 334
PHE A 319
ASP A 317
GLU A 294
 None
 1.15A 3kp6A-2fymA:
0.0
3kp6B-2fymA:
undetectable		 3kp6A-2fymA:
20.74
3kp6B-2fymA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 2fym ENOLASE
(Escherichia
coli) 		5 / 11 ALA A 335
ILE A 334
GLY A 333
SER A 337
LEU A 326
 None
 1.22A 3kw2A-2fymA:
undetectable		 3kw2A-2fymA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 2fym ENOLASE
(Escherichia
coli) 		5 / 11 ALA A 335
ILE A 334
GLY A 333
SER A 337
LEU A 326
 None
 1.22A 3kw2B-2fymA:
undetectable		 3kw2B-2fymA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 2fym ENOLASE
(Escherichia
coli) 		4 / 8 ALA A  22
ALA A  34
THR A 378
LEU A 129
 None
 1.02A 3l4dD-2fymA:
undetectable		 3l4dD-2fymA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 2fym ENOLASE
(Escherichia
coli) 		4 / 6 ALA A 118
ILE A 133
LEU A 348
ALA A  34
 None
 0.90A 3r9sA-2fymA:
undetectable		 3r9sA-2fymA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUN_A_CCSA165_0
(LYSOZYME)		 2fym ENOLASE
(Escherichia
coli) 		3 / 3 ASN A 101
ALA A  47
LYS A 102
 None
 1.01A 3runA-2fymA:
undetectable		 3runA-2fymA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)		 2fym ENOLASE
(Escherichia
coli) 		4 / 4 ASP A 293
ASP A 296
GLY A 291
THR A 304
 None
 1.19A 3tl9B-2fymA:
undetectable		 3tl9B-2fymA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_B_ADNB301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 2fym ENOLASE
(Escherichia
coli) 		5 / 10 ALA A 247
GLY A 291
LEU A 259
ASP A 293
LEU A 292
 None
 0.96A 3wdmB-2fymA:
undetectable		 3wdmB-2fymA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 2fym ENOLASE
(Escherichia
coli) 		5 / 10 ALA A 247
GLY A 291
LEU A 259
ASP A 293
LEU A 292
 None
 1.01A 3wdmD-2fymA:
undetectable		 3wdmD-2fymA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOS_A_4KOA201_1
(UNCHARACTERIZED
PROTEIN)		 2fym ENOLASE
(Escherichia
coli) 		5 / 12 GLY A 394
ASN A 151
MET A 150
ILE A 391
LEU A 339
 None
 1.09A 4kosA-2fymA:
undetectable		 4kosA-2fymA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOW_A_CFXA204_1
(UNCHARACTERIZED
PROTEIN)		 2fym ENOLASE
(Escherichia
coli) 		5 / 12 GLY A 394
ASN A 151
MET A 150
SER A 368
LEU A 339
 None
 1.22A 4kowA-2fymA:
0.0		 4kowA-2fymA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOY_A_CSCA214_1
(UNCHARACTERIZED
PROTEIN)		 2fym ENOLASE
(Escherichia
coli) 		5 / 11 GLY A 394
ASN A 151
MET A 150
ILE A 391
LEU A 339
 None
 1.02A 4koyA-2fymA:
undetectable		 4koyA-2fymA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2fym ENOLASE
(Escherichia
coli) 		5 / 11 MET A  93
GLY A 106
ALA A  36
LEU A 111
GLY A 346
 None
 1.12A 4kt0A-2fymA:
undetectable
4kt0J-2fymA:
undetectable		 4kt0A-2fymA:
21.20
4kt0J-2fymA:
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2fym ENOLASE
(Escherichia
coli) 		5 / 12 ALA A 159
ALA A 221
LEU A 215
LEU A 192
ILE A 225
 None
 1.17A 4lnwA-2fymA:
undetectable		 4lnwA-2fymA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2fym ENOLASE
(Escherichia
coli) 		5 / 12 ALA A 159
ALA A 221
LEU A 215
LEU A 192
ILE A 225
 None
 1.17A 4lnxA-2fymA:
undetectable		 4lnxA-2fymA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 2fym ENOLASE
(Escherichia
coli) 		4 / 6 ALA A 122
LYS A 125
LEU A 129
LEU A 136
 None
 1.26A 4xp3A-2fymA:
undetectable		 4xp3A-2fymA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 2fym ENOLASE
(Escherichia
coli) 		4 / 8 ILE A 152
LEU A 192
ILE A 170
LEU A 242
 None
 0.82A 4zvcA-2fymA:
0.3
4zvcB-2fymA:
0.5		 4zvcA-2fymA:
15.31
4zvcB-2fymA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 2fym ENOLASE
(Escherichia
coli) 		4 / 8 ILE A 170
LEU A 242
ILE A 152
LEU A 192
 None
 0.82A 4zvcA-2fymA:
0.3
4zvcB-2fymA:
0.5		 4zvcA-2fymA:
15.31
4zvcB-2fymA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2fym ENOLASE
(Escherichia
coli) 		4 / 6 ARG A  45
ASP A 290
GLY A 315
ASP A 316
 None
None
None
MG  A1431 (-3.3A)
 1.30A 5hp1A-2fymA:
undetectable		 5hp1A-2fymA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_C_PPFC601_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2fym ENOLASE
(Escherichia
coli) 		4 / 6 ARG A  45
ASP A 290
GLY A 315
ASP A 316
 None
None
None
MG  A1431 (-3.3A)
 0.91A 5hp1C-2fymA:
undetectable		 5hp1C-2fymA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 2fym ENOLASE
(Escherichia
coli) 		5 / 7 VAL A 224
LEU A 215
GLU A 227
ALA A 223
LEU A 192
 None
 1.46A 5jq7A-2fymA:
undetectable		 5jq7A-2fymA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 2fym ENOLASE
(Escherichia
coli) 		3 / 3 ALA A 175
VAL A 188
TYR A 234
 None
 0.72A 5zmqH-2fymA:
undetectable		 5zmqH-2fymA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 2fym ENOLASE
(Escherichia
coli) 		3 / 3 ALA A 175
VAL A 229
TYR A 234
 None
 0.71A 5zmqH-2fymA:
undetectable		 5zmqH-2fymA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_1
(HIV-1 PROTEASE)		 2fym ENOLASE
(Escherichia
coli) 		6 / 12 GLY A 174
ALA A 175
VAL A 178
ILE A 182
GLY A 185
ILE A 170
 None
 1.46A 6dj2B-2fymA:
undetectable		 6dj2B-2fymA:
11.37