SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fyw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_2
(POL POLYPROTEIN)		 2fyw CONSERVED
HYPOTHETICAL PROTEIN
(Streptococcus
pneumoniae) 		6 / 12 GLY A  57
ASP A 251
ILE A 250
ILE A 252
ILE A  61
ALA A   3
 None
 1.06A 1sguB-2fywA:
undetectable		 1sguB-2fywA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 2fyw CONSERVED
HYPOTHETICAL PROTEIN
(Streptococcus
pneumoniae) 		5 / 10 GLY A  57
ILE A 250
ILE A 252
ILE A  61
ALA A   3
 None
 1.00A 1sh9B-2fywA:
undetectable		 1sh9B-2fywA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 2fyw CONSERVED
HYPOTHETICAL PROTEIN
(Streptococcus
pneumoniae) 		4 / 8 ILE A 140
SER A 176
ASP A 198
LEU A 148
 None
 1.00A 2cdqA-2fywA:
undetectable		 2cdqA-2fywA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2fyw CONSERVED
HYPOTHETICAL PROTEIN
(Streptococcus
pneumoniae) 		4 / 8 GLY A 135
ASP A 103
ILE A 104
GLN A 126
 None
 0.80A 3fi0I-2fywA:
undetectable		 3fi0I-2fywA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 2fyw CONSERVED
HYPOTHETICAL PROTEIN
(Streptococcus
pneumoniae) 		4 / 8 LEU A 117
ILE A 119
ASN A 139
ILE A 175
 None
 0.90A 3wxoA-2fywA:
undetectable		 3wxoA-2fywA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_A_ECNA403_1
(FLAVOHEMOGLOBIN)		 2fyw CONSERVED
HYPOTHETICAL PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 GLN A 150
ALA A 149
LEU A 148
LEU A 117
ILE A 227
 None
 1.10A 4g1bA-2fywA:
undetectable		 4g1bA-2fywA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_A_ACTA401_0
(UNCHARACTERIZED
PROTEIN)		 2fyw CONSERVED
HYPOTHETICAL PROTEIN
(Streptococcus
pneumoniae) 		6 / 9 SER A 184
GLY A 183
TYR A 200
CYH A 181
GLY A 182
THR A 202
 None
 1.38A 4lb0A-2fywA:
undetectable		 4lb0A-2fywA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2fyw CONSERVED
HYPOTHETICAL PROTEIN
(Streptococcus
pneumoniae) 		5 / 10 THR A 259
ILE A  93
VAL A  95
ALA A  42
ILE A  61
 None
 0.98A 4lbgA-2fywA:
undetectable		 4lbgA-2fywA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2fyw CONSERVED
HYPOTHETICAL PROTEIN
(Streptococcus
pneumoniae) 		5 / 9 THR A 259
ILE A  93
VAL A  95
ALA A  42
ILE A  61
 None
 0.95A 4lbgB-2fywA:
undetectable		 4lbgB-2fywA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2fyw CONSERVED
HYPOTHETICAL PROTEIN
(Streptococcus
pneumoniae) 		4 / 8 HIS A  65
LYS A  64
SER A  98
SER A  19
 None
 1.24A 4ndnA-2fywA:
undetectable		 4ndnA-2fywA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 2fyw CONSERVED
HYPOTHETICAL PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 ILE A 134
ASP A 103
GLY A 185
HIS A  99
 None
 1.04A 4oltA-2fywA:
undetectable		 4oltA-2fywA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 2fyw CONSERVED
HYPOTHETICAL PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 ILE A 134
ASP A 103
GLY A 185
HIS A  99
 None
 1.06A 4oltB-2fywA:
undetectable		 4oltB-2fywA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_2
(ASPARTYL PROTEASE)		 2fyw CONSERVED
HYPOTHETICAL PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 LEU A 221
ILE A 180
GLY A 118
VAL A 199
ILE A 201
 None
 0.93A 4q1xB-2fywA:
undetectable		 4q1xB-2fywA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_2
(ASPARTYL PROTEASE)		 2fyw CONSERVED
HYPOTHETICAL PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 LEU A 221
ILE A 180
GLY A 118
VAL A 199
ILE A 201
 None
 0.95A 4q1yB-2fywA:
undetectable		 4q1yB-2fywA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2fyw CONSERVED
HYPOTHETICAL PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 ASP A  87
LYS A  90
HIS A  91
ILE A  54
 None
 1.18A 5a06A-2fywA:
undetectable		 5a06A-2fywA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2fyw CONSERVED
HYPOTHETICAL PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 ASP A  87
LYS A  90
HIS A  91
ILE A  54
 None
 1.18A 5a06B-2fywA:
undetectable		 5a06B-2fywA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1344_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2fyw CONSERVED
HYPOTHETICAL PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 ASP A  87
LYS A  90
HIS A  91
ILE A  54
 None
 1.20A 5a06D-2fywA:
undetectable		 5a06D-2fywA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1344_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2fyw CONSERVED
HYPOTHETICAL PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 ASP A  87
LYS A  90
HIS A  91
ILE A  54
 None
 1.16A 5a06F-2fywA:
undetectable		 5a06F-2fywA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 2fyw CONSERVED
HYPOTHETICAL PROTEIN
(Streptococcus
pneumoniae) 		4 / 4 CYH A 114
PHE A 113
ILE A 134
GLY A 108
 None
 1.22A 5hesB-2fywA:
0.0		 5hesB-2fywA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)		 2fyw CONSERVED
HYPOTHETICAL PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 LYS A  64
HIS A  65
HIS A  99
 None
 1.36A 5oexA-2fywA:
undetectable		 5oexA-2fywA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 2fyw CONSERVED
HYPOTHETICAL PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 LYS A  64
HIS A  65
HIS A  99
 None
 1.33A 5oexB-2fywA:
undetectable		 5oexB-2fywA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 2fyw CONSERVED
HYPOTHETICAL PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 LYS A  64
HIS A  65
HIS A  99
 None
 1.34A 5oexC-2fywA:
undetectable		 5oexC-2fywA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 2fyw CONSERVED
HYPOTHETICAL PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 LYS A  64
HIS A  65
HIS A  99
 None
 1.32A 5oexD-2fywA:
undetectable		 5oexD-2fywA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2fyw CONSERVED
HYPOTHETICAL PROTEIN
(Streptococcus
pneumoniae) 		6 / 11 LEU A 221
ILE A 201
GLY A 182
LEU A 161
SER A 160
VAL A 152
 None
 1.29A 5twjD-2fywA:
undetectable		 5twjD-2fywA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2fyw CONSERVED
HYPOTHETICAL PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 PHE A 188
ILE A  62
ILE A 104
PHE A  13
 None
 1.05A 5vkqA-2fywA:
undetectable
5vkqD-2fywA:
undetectable		 5vkqA-2fywA:
9.75
5vkqD-2fywA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 2fyw CONSERVED
HYPOTHETICAL PROTEIN
(Streptococcus
pneumoniae) 		4 / 4 PRO A 223
MET A 213
GLY A 217
VAL A 164
 None
 1.41A 6ak3A-2fywA:
undetectable		 6ak3A-2fywA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 2fyw CONSERVED
HYPOTHETICAL PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 GLY A  57
ASP A  59
ILE A 250
 None
 0.59A 6dgxB-2fywA:
undetectable		 6dgxB-2fywA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_0
(ADENOSYLHOMOCYSTEINA
SE)		 2fyw CONSERVED
HYPOTHETICAL PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 HIS A 225
ASP A 103
HIS A  65
GLY A 185
PHE A 113
 None
 1.48A 6exiA-2fywA:
undetectable		 6exiA-2fywA:
16.67