SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fz4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2fz4 DNA REPAIR PROTEIN
RAD25
(Archaeoglobus
fulgidus) 		4 / 8 SER A  51
LYS A  37
ARG A  55
TYR A  28
 None
 1.28A 1eqbA-2fz4A:
undetectable
1eqbB-2fz4A:
undetectable		 1eqbA-2fz4A:
20.76
1eqbB-2fz4A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2fz4 DNA REPAIR PROTEIN
RAD25
(Archaeoglobus
fulgidus) 		4 / 8 TYR A  28
SER A  51
LYS A  37
ARG A  55
 None
 1.34A 2vmyA-2fz4A:
undetectable
2vmyB-2fz4A:
undetectable		 2vmyA-2fz4A:
22.72
2vmyB-2fz4A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 2fz4 DNA REPAIR PROTEIN
RAD25
(Archaeoglobus
fulgidus) 		4 / 7 GLY A 162
ILE A  83
THR A  85
LEU A 174
 None
 0.99A 2xrhA-2fz4A:
undetectable		 2xrhA-2fz4A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_E_ACTE204_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 2fz4 DNA REPAIR PROTEIN
RAD25
(Archaeoglobus
fulgidus) 		3 / 3 LYS A 172
PRO A 173
LEU A 174
 None
 0.72A 3tpxE-2fz4A:
undetectable		 3tpxE-2fz4A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		 2fz4 DNA REPAIR PROTEIN
RAD25
(Archaeoglobus
fulgidus) 		4 / 8 TYR A  29
PHE A 193
SER A 181
ASN A 185
 None
 1.11A 5l1fA-2fz4A:
2.8
5l1fB-2fz4A:
undetectable		 5l1fA-2fz4A:
14.46
5l1fB-2fz4A:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 2fz4 DNA REPAIR PROTEIN
RAD25
(Archaeoglobus
fulgidus) 		4 / 7 GLY A 223
HIS A 202
GLU A 229
GLY A 118
 None
 0.78A 6n7fA-2fz4A:
undetectable		 6n7fA-2fz4A:
16.74