SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fzf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZT7_A_GLYA1300_0 (GLYCYL-TRNA SYNTHETASE)	2fzf	HYPOTHETICAL PROTEIN (Pyrococcus furiosus)	4 / 7	GLU A 117 GLU A 147 TYR A 39 GLU A 62	None	1.26A	2zt7A-2fzfA: undetectable	2zt7A-2fzfA: 13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LN1_A_CELA682_2 (PROSTAGLANDIN G/H SYNTHASE 2)	2fzf	HYPOTHETICAL PROTEIN (Pyrococcus furiosus)	4 / 8	ARG A 36 LEU A 42 SER A 41 ILE A 46	None	0.82A	3ln1A-2fzfA: undetectable	3ln1A-2fzfA: 14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LN1_B_CELB682_2 (PROSTAGLANDIN G/H SYNTHASE 2)	2fzf	HYPOTHETICAL PROTEIN (Pyrococcus furiosus)	4 / 7	ARG A 36 LEU A 42 SER A 41 ILE A 46	None	0.83A	3ln1B-2fzfA: undetectable	3ln1B-2fzfA: 14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3O1C_A_ADNA127_1 (HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN 1)	2fzf	HYPOTHETICAL PROTEIN (Pyrococcus furiosus)	5 / 10	ILE A 89 PHE A 123 ILE A 13 SER A 20 LEU A 127	None	1.07A	3o1cA-2fzfA: undetectable	3o1cA-2fzfA: 25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3R9T_C_BEZC264_0 (ECHA1_1)	2fzf	HYPOTHETICAL PROTEIN (Pyrococcus furiosus)	4 / 5	ALA A 35 GLU A 147 GLU A 117 ALA A 120	None	1.32A	3r9tC-2fzfA: undetectable	3r9tC-2fzfA: 20.77

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2ZT7_A_GLYA1300_0","GLYCYL-TRNA SYNTHETASE","2fzf","HYPOTHETICAL PROTEIN","Pyrococcus furiosus",4,"GLU A 117;GLU A 147;TYR A  39;GLU A  62","None","1.26A","2zt7A-2fzfA:undetectable","2zt7A-2fzfA:13.60"],["3LN1_A_CELA682_2","PROSTAGLANDIN G\/H SYNTHASE 2","2fzf","HYPOTHETICAL PROTEIN","Pyrococcus furiosus",4,"ARG A  36;LEU A  42;SER A  41;ILE A  46","None","0.82A","3ln1A-2fzfA:undetectable","3ln1A-2fzfA:14.83"],["3LN1_B_CELB682_2","PROSTAGLANDIN G\/H SYNTHASE 2","2fzf","HYPOTHETICAL PROTEIN","Pyrococcus furiosus",4,"ARG A  36;LEU A  42;SER A  41;ILE A  46","None","0.83A","3ln1B-2fzfA:undetectable","3ln1B-2fzfA:14.83"],["3O1C_A_ADNA127_1","HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN 1","2fzf","HYPOTHETICAL PROTEIN","Pyrococcus furiosus",5,"ILE A  89;PHE A 123;ILE A  13;SER A  20;LEU A 127","None","1.07A","3o1cA-2fzfA:undetectable","3o1cA-2fzfA:25.62"],["3R9T_C_BEZC264_0","ECHA1_1","2fzf","HYPOTHETICAL PROTEIN","Pyrococcus furiosus",4,"ALA A  35;GLU A 147;GLU A 117;ALA A 120","None","1.32A","3r9tC-2fzfA:undetectable","3r9tC-2fzfA:20.77"]]