SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fzl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 2fzl DNA REPAIR PROTEIN
RAD25, XPB
(Archaeoglobus
fulgidus) 		4 / 8 LEU A 387
GLU A 384
GLU A 385
ILE A 374
 None
 1.05A 1qvtA-2fzlA:
undetectable		 1qvtA-2fzlA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2fzl DNA REPAIR PROTEIN
RAD25, XPB
(Archaeoglobus
fulgidus) 		5 / 12 ILE A 418
LEU A 450
ALA A 425
GLY A 423
SER A 422
 None
 1.12A 2a58A-2fzlA:
undetectable
2a58B-2fzlA:
undetectable		 2a58A-2fzlA:
21.17
2a58B-2fzlA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2fzl DNA REPAIR PROTEIN
RAD25, XPB
(Archaeoglobus
fulgidus) 		5 / 12 ILE A 418
LEU A 450
ALA A 425
GLY A 423
SER A 422
 None
 1.12A 2a58B-2fzlA:
undetectable
2a58C-2fzlA:
undetectable		 2a58B-2fzlA:
21.17
2a58C-2fzlA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2fzl DNA REPAIR PROTEIN
RAD25, XPB
(Archaeoglobus
fulgidus) 		5 / 12 ILE A 418
LEU A 450
ALA A 425
GLY A 423
SER A 422
 None
 1.12A 2a58D-2fzlA:
undetectable
2a58E-2fzlA:
undetectable		 2a58D-2fzlA:
21.17
2a58E-2fzlA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2fzl DNA REPAIR PROTEIN
RAD25, XPB
(Archaeoglobus
fulgidus) 		4 / 8 GLY A 421
ILE A 343
VAL A 399
SER A 452
 None
 0.90A 2yoeB-2fzlA:
2.1
2yoeC-2fzlA:
2.2		 2yoeB-2fzlA:
22.48
2yoeC-2fzlA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 2fzl DNA REPAIR PROTEIN
RAD25, XPB
(Archaeoglobus
fulgidus) 		5 / 12 ILE A 352
ALA A 413
ASP A 405
ILE A 435
ILE A 354
 None
 1.05A 4m2xE-2fzlA:
undetectable		 4m2xE-2fzlA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 2fzl DNA REPAIR PROTEIN
RAD25, XPB
(Archaeoglobus
fulgidus) 		4 / 6 ILE A 418
HIS A 376
ILE A 408
VAL A 410
 None
 0.93A 4zj8A-2fzlA:
3.0		 4zj8A-2fzlA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 2fzl DNA REPAIR PROTEIN
RAD25, XPB
(Archaeoglobus
fulgidus) 		5 / 6 THR A 392
GLY A 389
GLU A 388
PHE A 390
ILE A 374
 None
 1.49A 5kmfA-2fzlA:
undetectable
5kmfC-2fzlA:
2.7		 5kmfA-2fzlA:
25.08
5kmfC-2fzlA:
25.08