SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fzw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN
(Homo
sapiens) 		5 / 11 CYH A  44
HIS A  66
LEU A 109
CYH A 173
VAL A 293
 ZN  A 376 (-2.4A)
ZN  A 376 (-3.3A)
None
ZN  A 376 ( 3.0A)
NAD  A1377 (-4.6A)
 0.91A 1ee2A-2fzwA:
58.3		 1ee2A-2fzwA:
62.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN
(Homo
sapiens) 		5 / 11 CYH A  44
HIS A  66
LEU A 109
CYH A 173
VAL A 293
 ZN  A 376 (-2.4A)
ZN  A 376 (-3.3A)
None
ZN  A 376 ( 3.0A)
NAD  A1377 (-4.6A)
 0.94A 1ee2B-2fzwA:
58.4		 1ee2B-2fzwA:
62.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN
(Homo
sapiens) 		5 / 12 ALA A 152
GLY A 120
GLY A 141
SER A 143
LEU A 121
 None
 0.98A 1rjdA-2fzwA:
3.2		 1rjdA-2fzwA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN
(Homo
sapiens) 		5 / 12 ALA A 152
GLY A 120
GLY A 141
SER A 143
LEU A 121
 None
 0.99A 1rjdB-2fzwA:
2.9		 1rjdB-2fzwA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN
(Homo
sapiens) 		5 / 12 ALA A 152
GLY A 120
GLY A 141
SER A 143
LEU A 121
 None
 0.99A 1rjdC-2fzwA:
3.0		 1rjdC-2fzwA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN
(Homo
sapiens) 		5 / 11 GLY A 178
ALA A 181
ALA A 186
LEU A 188
VAL A 289
 None
 1.04A 1ukbA-2fzwA:
3.5		 1ukbA-2fzwA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN
(Homo
sapiens) 		5 / 12 ALA A 280
GLY A 260
ALA A 276
SER A 264
PHE A 197
 None
 1.16A 1ve3B-2fzwA:
5.8		 1ve3B-2fzwA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLD_A_ASCA130_0
(CYTOCHROME C')		 2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN
(Homo
sapiens) 		4 / 5 ALA A  42
GLY A 174
CYH A 173
HIS A  66
 None
NAD  A1377 ( 4.4A)
ZN  A 376 ( 3.0A)
ZN  A 376 (-3.3A)
 1.47A 2yldA-2fzwA:
undetectable		 2yldA-2fzwA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN
(Homo
sapiens) 		5 / 12 LEU A 170
ILE A 367
PHE A 344
ILE A 207
GLU A 266
 None
 1.07A 3nxuA-2fzwA:
undetectable		 3nxuA-2fzwA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZWI_A_ASCA156_0
(CYTOCHROME C')		 2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN
(Homo
sapiens) 		4 / 5 ALA A  42
GLY A 174
CYH A 173
HIS A  66
 None
NAD  A1377 ( 4.4A)
ZN  A 376 ( 3.0A)
ZN  A 376 (-3.3A)
 1.47A 3zwiA-2fzwA:
undetectable		 3zwiA-2fzwA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN
(Homo
sapiens) 		5 / 10 GLY A 203
ALA A 181
GLY A 178
VAL A 196
CYH A 210
 None
 1.26A 4c5nD-2fzwA:
5.2		 4c5nD-2fzwA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CIP_A_ASCA130_0
(CYTOCHROME C')		 2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN
(Homo
sapiens) 		4 / 4 ALA A  42
GLY A 174
CYH A 173
HIS A  66
 None
NAD  A1377 ( 4.4A)
ZN  A 376 ( 3.0A)
ZN  A 376 (-3.3A)
 1.47A 4cipA-2fzwA:
undetectable		 4cipA-2fzwA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN
(Homo
sapiens) 		5 / 8 ALA A  69
VAL A 168
PRO A 328
VAL A 327
ILE A  89
 None
 1.29A 4ll3A-2fzwA:
undetectable		 4ll3A-2fzwA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN
(Homo
sapiens) 		3 / 3 ASP A 226
ASN A 241
SER A 363
 None
 0.85A 4obwA-2fzwA:
6.8		 4obwA-2fzwA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_1
(ANDROGEN RECEPTOR)		 2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN
(Homo
sapiens) 		5 / 12 LEU A 171
GLY A 172
LEU A  91
VAL A  88
THR A 144
 None
 1.20A 4ojbA-2fzwA:
undetectable		 4ojbA-2fzwA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_1
(ANDROGEN RECEPTOR)		 2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN
(Homo
sapiens) 		5 / 12 LEU A 171
GLY A 172
LEU A  91
VAL A  88
THR A 144
 None
 1.19A 4okbA-2fzwA:
undetectable		 4okbA-2fzwA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_1
(ANDROGEN RECEPTOR)		 2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN
(Homo
sapiens) 		5 / 12 LEU A 171
GLY A 172
LEU A  91
VAL A  88
THR A 144
 None
 1.20A 4okxA-2fzwA:
undetectable		 4okxA-2fzwA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN
(Homo
sapiens) 		3 / 3 VAL A 168
LEU A 171
VAL A 341
 None
 0.60A 4wq4A-2fzwA:
undetectable		 4wq4A-2fzwA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_A_ADNA301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN
(Homo
sapiens) 		5 / 9 PRO A 242
LEU A 199
GLY A 198
ILE A 240
VAL A 196
 None
None
NAD  A1377 (-3.6A)
None
None
 1.11A 4x3mA-2fzwA:
3.0		 4x3mA-2fzwA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN
(Homo
sapiens) 		4 / 7 ASN A 224
LYS A 225
LYS A 227
PHE A 265
 None
None
NAD  A1377 ( 4.8A)
None
 1.23A 4yv5A-2fzwA:
undetectable		 4yv5A-2fzwA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLI_A_ASCA202_0
(CYTOCHROME C')		 2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN
(Homo
sapiens) 		4 / 5 ALA A  42
GLY A 174
CYH A 173
HIS A  66
 None
NAD  A1377 ( 4.4A)
ZN  A 376 ( 3.0A)
ZN  A 376 (-3.3A)
 1.49A 5jliA-2fzwA:
undetectable		 5jliA-2fzwA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JT4_A_ASCA202_0
(CYTOCHROME C')		 2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN
(Homo
sapiens) 		4 / 5 ALA A  42
GLY A 174
CYH A 173
HIS A  66
 None
NAD  A1377 ( 4.4A)
ZN  A 376 ( 3.0A)
ZN  A 376 (-3.3A)
 1.50A 5jt4A-2fzwA:
undetectable		 5jt4A-2fzwA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN
(Homo
sapiens) 		4 / 6 GLY A 319
THR A 177
SER A 176
GLY A 174
 None
NAD  A1377 (-3.0A)
None
NAD  A1377 ( 4.4A)
 0.79A 5k4pA-2fzwA:
undetectable		 5k4pA-2fzwA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)		 2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN
(Homo
sapiens) 		5 / 12 ALA A  69
LEU A 170
ILE A 175
VAL A 327
PHE A 318
 None
 1.26A 5vlmB-2fzwA:
undetectable		 5vlmB-2fzwA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN
(Homo
sapiens) 		5 / 12 ALA A  69
LEU A 170
ILE A 175
VAL A 327
PHE A 318
 None
 1.28A 5vlmE-2fzwA:
undetectable		 5vlmE-2fzwA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN
(Homo
sapiens) 		5 / 12 ALA A  69
LEU A 170
ILE A 175
VAL A 327
PHE A 318
 None
 1.32A 5vlmG-2fzwA:
undetectable		 5vlmG-2fzwA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN
(Homo
sapiens) 		5 / 12 GLY A 198
ASP A 222
ILE A 223
ASN A 224
LYS A 227
 NAD  A1377 (-3.6A)
NAD  A1377 (-2.9A)
NAD  A1377 (-4.0A)
None
NAD  A1377 ( 4.8A)
 0.68A 5wy0A-2fzwA:
undetectable		 5wy0A-2fzwA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN
(Homo
sapiens) 		4 / 8 PRO A  90
THR A  41
THR A 144
PRO A 164
 None
 1.34A 5x2sI-2fzwA:
undetectable
5x2sJ-2fzwA:
undetectable
5x2sK-2fzwA:
undetectable		 5x2sI-2fzwA:
15.99
5x2sJ-2fzwA:
18.53
5x2sK-2fzwA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN
(Homo
sapiens) 		4 / 5 ILE A 249
PHE A 197
ARG A 311
THR A 302
 None
 1.27A 5z84N-2fzwA:
undetectable
5z84W-2fzwA:
undetectable		 5z84N-2fzwA:
20.41
5z84W-2fzwA:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN
(Homo
sapiens) 		5 / 12 ILE A 249
ALA A 280
ALA A 277
LEU A 253
ILE A 223
 None
None
None
None
NAD  A1377 (-4.0A)
 1.15A 6a5zD-2fzwA:
undetectable		 6a5zD-2fzwA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN
(Homo
sapiens) 		3 / 3 TYR A 179
ALA A 186
LEU A 188
 None
 0.67A 6ag0C-2fzwA:
undetectable		 6ag0C-2fzwA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN
(Homo
sapiens) 		5 / 12 GLY A 178
HIS A  66
TYR A  92
CYH A  44
GLY A 172
 None
ZN  A 376 (-3.3A)
None
ZN  A 376 (-2.4A)
None
 1.48A 6bp4B-2fzwA:
undetectable		 6bp4B-2fzwA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN
(Homo
sapiens) 		5 / 12 GLY A 178
HIS A  66
TYR A  92
LEU A  67
GLY A 172
 None
ZN  A 376 (-3.3A)
None
None
None
 1.43A 6bp4B-2fzwA:
undetectable		 6bp4B-2fzwA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN
(Homo
sapiens) 		5 / 12 GLY A 201
ILE A 175
HIS A  66
LEU A  67
GLY A 172
 NAD  A1377 (-3.8A)
None
ZN  A 376 (-3.3A)
None
None
 1.28A 6bp4B-2fzwA:
undetectable		 6bp4B-2fzwA:
20.51