SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2g04'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 2g04 PROBABLE
FATTY-ACID-COA
RACEMASE FAR
(Mycobacterium
tuberculosis) 		5 / 8 ARG A 112
ALA A  24
GLY A  19
ILE A  18
VAL A 166
 None
 1.24A 1d4sB-2g04A:
undetectable		 1d4sB-2g04A:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2g04 PROBABLE
FATTY-ACID-COA
RACEMASE FAR
(Mycobacterium
tuberculosis) 		5 / 11 GLY A 120
PRO A 121
ASP A 192
LEU A 165
ILE A 113
 None
 1.10A 1jzsA-2g04A:
undetectable		 1jzsA-2g04A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_A_ANWA99_0
(PROTEIN S100-A13)		 2g04 PROBABLE
FATTY-ACID-COA
RACEMASE FAR
(Mycobacterium
tuberculosis) 		4 / 7 VAL A 300
THR A 301
PHE A 293
THR A 290
 None
 1.12A 2kotA-2g04A:
undetectable		 2kotA-2g04A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2g04 PROBABLE
FATTY-ACID-COA
RACEMASE FAR
(Mycobacterium
tuberculosis) 		4 / 7 VAL A 344
GLY A 342
ALA A 341
LEU A  31
 None
 0.81A 2wekB-2g04A:
5.7		 2wekB-2g04A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_1
(PROTEASE)		 2g04 PROBABLE
FATTY-ACID-COA
RACEMASE FAR
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  25
ALA A  24
GLY A  19
ILE A  18
VAL A 166
 None
 0.90A 3el4A-2g04A:
undetectable		 3el4A-2g04A:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2g04 PROBABLE
FATTY-ACID-COA
RACEMASE FAR
(Mycobacterium
tuberculosis) 		5 / 10 ALA A  71
VAL A  65
ALA A  79
ILE A  13
LEU A  15
 None
 1.22A 3fl9A-2g04A:
undetectable		 3fl9A-2g04A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2g04 PROBABLE
FATTY-ACID-COA
RACEMASE FAR
(Mycobacterium
tuberculosis) 		5 / 11 ALA A  71
LEU A  63
VAL A  65
ILE A  13
LEU A  15
 None
 1.13A 3fl9C-2g04A:
undetectable		 3fl9C-2g04A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2g04 PROBABLE
FATTY-ACID-COA
RACEMASE FAR
(Mycobacterium
tuberculosis) 		5 / 10 ALA A  71
LEU A  63
VAL A  65
ILE A  13
LEU A  15
 None
 1.11A 3fl9E-2g04A:
undetectable		 3fl9E-2g04A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2g04 PROBABLE
FATTY-ACID-COA
RACEMASE FAR
(Mycobacterium
tuberculosis) 		5 / 12 ALA A  71
LEU A  63
VAL A  65
ILE A  13
LEU A  15
 None
 1.15A 3fl9G-2g04A:
undetectable		 3fl9G-2g04A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2g04 PROBABLE
FATTY-ACID-COA
RACEMASE FAR
(Mycobacterium
tuberculosis) 		5 / 9 ALA A  71
LEU A  63
VAL A  65
ILE A  13
LEU A  15
 None
 1.11A 3fl9H-2g04A:
undetectable		 3fl9H-2g04A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		 2g04 PROBABLE
FATTY-ACID-COA
RACEMASE FAR
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 221
PHE A 142
ARG A 214
ALA A 141
ALA A 138
 None
 1.10A 3keeA-2g04A:
undetectable		 3keeA-2g04A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_2
(PROTEASE)		 2g04 PROBABLE
FATTY-ACID-COA
RACEMASE FAR
(Mycobacterium
tuberculosis) 		5 / 10 GLY A  25
ALA A  24
GLY A  19
ILE A  18
VAL A 166
 None
 0.95A 3nu9B-2g04A:
undetectable		 3nu9B-2g04A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 2g04 PROBABLE
FATTY-ACID-COA
RACEMASE FAR
(Mycobacterium
tuberculosis) 		4 / 8 ALA A  24
VAL A  27
LEU A  31
LEU A 168
 None
 0.80A 3roxA-2g04A:
5.1		 3roxA-2g04A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_2
(POL POLYPROTEIN)		 2g04 PROBABLE
FATTY-ACID-COA
RACEMASE FAR
(Mycobacterium
tuberculosis) 		5 / 9 GLY A  25
ALA A  24
GLY A  19
ILE A  18
VAL A 166
 None
 1.06A 3u7sB-2g04A:
undetectable		 3u7sB-2g04A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2g04 PROBABLE
FATTY-ACID-COA
RACEMASE FAR
(Mycobacterium
tuberculosis) 		4 / 8 ASP A 100
ILE A  96
GLY A  95
VAL A  38
 None
 0.77A 4acbB-2g04A:
3.8
4acbC-2g04A:
undetectable		 4acbB-2g04A:
21.44
4acbC-2g04A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J5J_B_478B401_2
(PROTEASE)		 2g04 PROBABLE
FATTY-ACID-COA
RACEMASE FAR
(Mycobacterium
tuberculosis) 		5 / 10 ALA A  24
ILE A 113
ILE A  13
VAL A 186
VAL A 166
 None
 1.04A 4j5jB-2g04A:
undetectable		 4j5jB-2g04A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 2g04 PROBABLE
FATTY-ACID-COA
RACEMASE FAR
(Mycobacterium
tuberculosis) 		5 / 10 MET A 237
ALA A 241
ALA A 298
THR A 296
VAL A 292
 None
 1.20A 4j6cB-2g04A:
undetectable		 4j6cB-2g04A:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2g04 PROBABLE
FATTY-ACID-COA
RACEMASE FAR
(Mycobacterium
tuberculosis) 		3 / 3 LEU A  83
ARG A  37
MET A  46
 None
 0.92A 4m11C-2g04A:
undetectable		 4m11C-2g04A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		 2g04 PROBABLE
FATTY-ACID-COA
RACEMASE FAR
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 222
LEU A 210
MET A 204
ILE A 242
PHE A 225
 None
 1.23A 4p6xI-2g04A:
undetectable		 4p6xI-2g04A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 2g04 PROBABLE
FATTY-ACID-COA
RACEMASE FAR
(Mycobacterium
tuberculosis) 		4 / 5 ARG A  37
GLY A  16
GLY A  21
PRO A  22
 None
 0.81A 4u9uA-2g04A:
2.8		 4u9uA-2g04A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 2g04 PROBABLE
FATTY-ACID-COA
RACEMASE FAR
(Mycobacterium
tuberculosis) 		4 / 5 ARG A  37
GLY A  17
GLY A  21
PRO A  22
 None
 0.90A 4u9uA-2g04A:
2.8		 4u9uA-2g04A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 2g04 PROBABLE
FATTY-ACID-COA
RACEMASE FAR
(Mycobacterium
tuberculosis) 		4 / 5 ARG A  37
GLY A  16
GLY A  21
PRO A  22
 None
 0.86A 4u9uB-2g04A:
4.9		 4u9uB-2g04A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 2g04 PROBABLE
FATTY-ACID-COA
RACEMASE FAR
(Mycobacterium
tuberculosis) 		4 / 5 ARG A  37
GLY A  17
GLY A  21
PRO A  22
 None
 0.95A 4u9uB-2g04A:
4.9		 4u9uB-2g04A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 2g04 PROBABLE
FATTY-ACID-COA
RACEMASE FAR
(Mycobacterium
tuberculosis) 		5 / 7 GLY A 193
GLY A 162
PHE A 159
GLY A 160
VAL A 194
 None
 0.98A 5izjB-2g04A:
undetectable		 5izjB-2g04A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 2g04 PROBABLE
FATTY-ACID-COA
RACEMASE FAR
(Mycobacterium
tuberculosis) 		5 / 7 GLY A 193
GLY A 162
SER A 163
GLY A 160
VAL A 194
 None
 1.13A 5izjB-2g04A:
undetectable		 5izjB-2g04A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 2g04 PROBABLE
FATTY-ACID-COA
RACEMASE FAR
(Mycobacterium
tuberculosis) 		5 / 10 GLY A  95
ILE A  13
LEU A  75
LEU A  73
ALA A  76
 None
 1.05A 5l0zB-2g04A:
3.2		 5l0zB-2g04A:
23.20