SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2g0b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2g0b FEEM
(uncultured
bacterium) 		4 / 4 ALA A 109
VAL A 108
ALA A 107
HIS A 102
 None
 1.16A 1q23A-2g0bA:
undetectable		 1q23A-2g0bA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2g0b FEEM
(uncultured
bacterium) 		4 / 4 ALA A 109
VAL A 108
ALA A 107
HIS A 102
 None
 1.13A 1q23K-2g0bA:
undetectable		 1q23K-2g0bA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_B_FK5B401_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 2g0b FEEM
(uncultured
bacterium) 		5 / 10 ASP A  75
ARG A  86
VAL A  96
TYR A 163
ILE A  77
 None
None
NLT  A 400 (-3.4A)
None
None
 1.40A 1q6iB-2g0bA:
undetectable		 1q6iB-2g0bA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_B_ACTB1463_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 2g0b FEEM
(uncultured
bacterium) 		4 / 7 VAL A 166
ALA A 170
GLY A 164
THR A 165
 NLT  A 400 (-4.5A)
NLT  A 400 ( 3.7A)
None
None
 0.73A 2xrzB-2g0bA:
undetectable		 2xrzB-2g0bA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 2g0b FEEM
(uncultured
bacterium) 		5 / 12 ILE A 141
THR A  61
PHE A 154
ALA A 174
ALA A  93
 NLT  A 400 (-4.9A)
None
NLT  A 400 (-4.7A)
None
None
 1.37A 3ua1A-2g0bA:
undetectable		 3ua1A-2g0bA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 2g0b FEEM
(uncultured
bacterium) 		4 / 8 ALA A  18
ALA A  19
ILE A  22
ALA A   7
 None
 0.64A 4v1fA-2g0bA:
undetectable
4v1fB-2g0bA:
undetectable		 4v1fA-2g0bA:
20.74
4v1fB-2g0bA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2g0b FEEM
(uncultured
bacterium) 		5 / 12 ALA A  47
LEU A  72
THR A 132
ILE A 134
LEU A 137
 None
 1.14A 4x5hA-2g0bA:
undetectable		 4x5hA-2g0bA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_B_FK5B201_1
(FK506-BINDING
PROTEIN 1)		 2g0b FEEM
(uncultured
bacterium) 		5 / 11 ASP A  75
ARG A  86
VAL A  96
TYR A 163
ILE A  77
 None
None
NLT  A 400 (-3.4A)
None
None
 1.33A 5hw8B-2g0bA:
undetectable		 5hw8B-2g0bA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWC_A_FK5A201_1
(FK506-BINDING
PROTEIN 1A)		 2g0b FEEM
(uncultured
bacterium) 		5 / 11 ASP A  75
ARG A  86
VAL A  96
TYR A 163
ILE A  77
 None
None
NLT  A 400 (-3.4A)
None
None
 1.31A 5hwcA-2g0bA:
undetectable		 5hwcA-2g0bA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 2g0b FEEM
(uncultured
bacterium) 		4 / 7 GLN A 183
LEU A 175
ALA A  93
LEU A  72
 None
 1.11A 5nwvA-2g0bA:
undetectable		 5nwvA-2g0bA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2g0b FEEM
(uncultured
bacterium) 		4 / 5 GLN A 183
VAL A 177
TRP A 180
THR A 127
 None
 1.22A 6cduA-2g0bA:
0.0
6cduB-2g0bA:
0.0		 6cduA-2g0bA:
20.61
6cduB-2g0bA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2g0b FEEM
(uncultured
bacterium) 		5 / 7 ALA A 129
THR A 127
GLN A 183
VAL A 177
TRP A 180
 None
 1.42A 6cduA-2g0bA:
undetectable
6cduE-2g0bA:
undetectable		 6cduA-2g0bA:
20.61
6cduE-2g0bA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2g0b FEEM
(uncultured
bacterium) 		5 / 6 GLN A 183
VAL A 177
TRP A 180
ALA A 129
THR A 127
 None
 1.39A 6cduB-2g0bA:
undetectable
6cduC-2g0bA:
undetectable		 6cduB-2g0bA:
20.61
6cduC-2g0bA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2g0b FEEM
(uncultured
bacterium) 		5 / 8 GLN A 183
VAL A 177
TRP A 180
ALA A 129
THR A 127
 None
 1.49A 6cduD-2g0bA:
undetectable
6cduE-2g0bA:
undetectable		 6cduD-2g0bA:
20.61
6cduE-2g0bA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2g0b FEEM
(uncultured
bacterium) 		5 / 7 ALA A 129
THR A 127
GLN A 183
VAL A 177
TRP A 180
 None
 1.41A 6cduF-2g0bA:
undetectable
6cduJ-2g0bA:
undetectable		 6cduF-2g0bA:
20.61
6cduJ-2g0bA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2g0b FEEM
(uncultured
bacterium) 		5 / 7 GLN A 183
VAL A 177
TRP A 180
ALA A 129
THR A 127
 None
 1.48A 6cduH-2g0bA:
undetectable
6cduI-2g0bA:
undetectable		 6cduH-2g0bA:
20.61
6cduI-2g0bA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_I_EY4I500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2g0b FEEM
(uncultured
bacterium) 		4 / 5 GLN A 183
VAL A 177
TRP A 180
THR A 127
 None
 1.17A 6cduI-2g0bA:
0.1
6cduJ-2g0bA:
0.1		 6cduI-2g0bA:
20.61
6cduJ-2g0bA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_1
(PEPTIDYLPROLYL
ISOMERASE)		 2g0b FEEM
(uncultured
bacterium) 		5 / 10 ASP A  75
ARG A  86
VAL A  96
TYR A 163
ILE A  77
 None
None
NLT  A 400 (-3.4A)
None
None
 1.34A 6mkeC-2g0bA:
undetectable		 6mkeC-2g0bA:
17.28