SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2g0t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2g0t CONSERVED
HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		4 / 6 ALA A  26
LEU A 114
LEU A  92
LEU A  99
 None
 0.99A 1mt1D-2g0tA:
undetectable
1mt1E-2g0tA:
0.0		 1mt1D-2g0tA:
17.57
1mt1E-2g0tA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2g0t CONSERVED
HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		4 / 5 GLY A  31
PRO A  41
ALA A  13
ILE A  82
 None
 0.88A 2aofA-2g0tA:
undetectable		 2aofA-2g0tA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2g0t CONSERVED
HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		4 / 7 GLY A 202
ILE A 201
VAL A 208
ILE A 138
 None
 0.71A 2aojB-2g0tA:
undetectable		 2aojB-2g0tA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2g0t CONSERVED
HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		4 / 7 VAL A 307
LEU A 178
PHE A 323
THR A 173
 None
 1.13A 2f78B-2g0tA:
undetectable		 2f78B-2g0tA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 2g0t CONSERVED
HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		4 / 8 VAL A 110
PHE A 124
ALA A  97
GLN A 121
 None
 1.15A 2ij7C-2g0tA:
undetectable		 2ij7C-2g0tA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 2g0t CONSERVED
HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		3 / 3 ASN A  87
ASP A 210
GLN A 241
 None
None
EDO  A 341 (-3.1A)
 0.84A 3eeyC-2g0tA:
4.8		 3eeyC-2g0tA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 2g0t CONSERVED
HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		3 / 3 ASN A  87
ASP A 210
GLN A 241
 None
None
EDO  A 341 (-3.1A)
 0.83A 3eeyD-2g0tA:
4.8		 3eeyD-2g0tA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 2g0t CONSERVED
HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		5 / 12 LEU A 200
GLY A 195
ILE A  83
SER A  86
LEU A 114
 None
EDO  A 341 (-3.6A)
None
None
None
 1.26A 3gyqA-2g0tA:
3.0
3gyqB-2g0tA:
undetectable		 3gyqA-2g0tA:
22.44
3gyqB-2g0tA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 2g0t CONSERVED
HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		4 / 8 SER A 119
PHE A 116
LEU A  92
PRO A  88
 None
 1.24A 3jq7B-2g0tA:
5.2		 3jq7B-2g0tA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2g0t CONSERVED
HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		3 / 3 TYR A 249
ASP A 166
ASP A 274
 None
 0.78A 3ou6B-2g0tA:
2.8		 3ou6B-2g0tA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2g0t CONSERVED
HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		5 / 11 ILE A 295
ALA A 243
PHE A 163
LEU A 257
THR A 165
 None
 1.33A 3qg2B-2g0tA:
2.4		 3qg2B-2g0tA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_1
(ESTROGEN RECEPTOR)		 2g0t CONSERVED
HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		5 / 12 LEU A 104
ALA A 103
LEU A  99
LEU A  81
GLY A  77
 None
 1.02A 4xi3C-2g0tA:
undetectable		 4xi3C-2g0tA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)		 2g0t CONSERVED
HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		3 / 3 LEU A 257
VAL A 159
ASP A 263
 None
 0.52A 4y8wC-2g0tA:
undetectable		 4y8wC-2g0tA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 2g0t CONSERVED
HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		5 / 9 ALA A 189
PHE A 237
GLU A 180
LEU A 332
ILE A 187
 None
 1.31A 5i73A-2g0tA:
0.0		 5i73A-2g0tA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2g0t CONSERVED
HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		5 / 8 GLY A 198
LEU A 200
GLN A 196
VAL A 208
LEU A   3
 None
 1.44A 6czmD-2g0tA:
undetectable
6czmF-2g0tA:
undetectable		 6czmD-2g0tA:
24.21
6czmF-2g0tA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2g0t CONSERVED
HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		5 / 10 VAL A 208
LEU A   3
GLY A 198
LEU A 200
GLN A 196
 None
 1.33A 6czmE-2g0tA:
undetectable
6czmF-2g0tA:
undetectable		 6czmE-2g0tA:
24.21
6czmF-2g0tA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2g0t CONSERVED
HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		5 / 10 LEU A  38
GLY A 198
ILE A 199
ILE A 111
ILE A  82
 None
 0.99A 6ebpD-2g0tA:
undetectable		 6ebpD-2g0tA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2g0t CONSERVED
HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		5 / 11 LEU A  38
GLY A 198
ILE A 199
ILE A 111
ILE A  82
 None
 1.00A 6ebzA-2g0tA:
undetectable		 6ebzA-2g0tA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2g0t CONSERVED
HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		5 / 11 LEU A  38
GLY A 198
ILE A 199
ILE A 111
ILE A  82
 None
 1.00A 6ebzB-2g0tA:
undetectable		 6ebzB-2g0tA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2g0t CONSERVED
HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		5 / 11 LEU A  38
GLY A 198
ILE A 199
ILE A 111
ILE A  82
 None
 1.00A 6ebzC-2g0tA:
undetectable		 6ebzC-2g0tA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2g0t CONSERVED
HYPOTHETICAL PROTEIN
(Thermotoga
maritima) 		5 / 11 LEU A  38
GLY A 198
ILE A 199
ILE A 111
ILE A  82
 None
 1.01A 6ebzD-2g0tA:
undetectable		 6ebzD-2g0tA:
13.86