SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2g1k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 2g1k SHIKIMATE KINASE
(Mycobacterium
tuberculosis) 		5 / 8 GLY A  81
GLY A  80
GLY A  79
ALA A  82
ILE A  45
 SKM  A 401 (-3.3A)
SKM  A 401 (-4.1A)
SKM  A 401 (-3.5A)
None
SKM  A 401 ( 4.6A)
 0.98A 1yajC-2g1kA:
undetectable		 1yajC-2g1kA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 2g1k SHIKIMATE KINASE
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 132
ARG A  58
LEU A  10
PRO A  11
 None
SKM  A 401 (-2.9A)
None
SO4  A 501 (-4.7A)
 1.12A 3onnA-2g1kA:
undetectable		 3onnA-2g1kA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)		 2g1k SHIKIMATE KINASE
(Mycobacterium
tuberculosis) 		4 / 7 GLY A 156
VAL A 159
ASN A 154
GLY A  14
 None
None
None
SO4  A 501 (-3.1A)
 0.73A 4forA-2g1kA:
undetectable		 4forA-2g1kA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 2g1k SHIKIMATE KINASE
(Mycobacterium
tuberculosis) 		5 / 11 ILE A 162
LEU A  26
ALA A   5
THR A 145
VAL A 148
 None
 1.15A 4h1nA-2g1kA:
undetectable		 4h1nA-2g1kA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2g1k SHIKIMATE KINASE
(Mycobacterium
tuberculosis) 		4 / 7 ILE A  18
GLY A  14
LEU A  69
ASP A  32
 None
SO4  A 501 (-3.1A)
None
None
 0.81A 5hieB-2g1kA:
undetectable		 5hieB-2g1kA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)		 2g1k SHIKIMATE KINASE
(Mycobacterium
tuberculosis) 		4 / 5 GLU A  61
THR A  33
HIS A  72
LEU A  69
 SKM  A 401 ( 4.7A)
None
None
None
 1.17A 5utuH-2g1kA:
undetectable		 5utuH-2g1kA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2g1k SHIKIMATE KINASE
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 136
PHE A  49
ARG A  58
 SKM  A 401 (-2.7A)
SKM  A 401 ( 4.9A)
SKM  A 401 (-2.9A)
 0.97A 5y9yA-2g1kA:
undetectable		 5y9yA-2g1kA:
20.97