SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2g28'

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1A4L_C_DCFC1353_2 (ADENOSINE DEAMINASE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	4 / 5	LEU A 475 LEU A 473 SER A 584 LEU A 590	None	0.96A	1a4lC-2g28A: undetectable	1a4lC-2g28A: 17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EA1_A_TPFA470_1 (CYTOCHROME P450 51-LIKE RV0764C)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	4 / 8	TYR A 322 PHE A 325 THR A 344 LEU A 313	None	1.26A	1ea1A-2g28A: undetectable	1ea1A-2g28A: 18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1J3J_A_CP6A609_1 (BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 10	ILE A 369 ASN A 258 SER A 109 ILE A 143 ILE A 116	None	1.30A	1j3jA-2g28A: undetectable	1j3jA-2g28A: 14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MXD_A_ACRA733_1 (ALPHA AMYLASE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	4 / 6	SER A 220 ASN A 252 LEU A 250 ASP A 251	None	1.33A	1mxdA-2g28A: undetectable	1mxdA-2g28A: 19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XIU_A_9CRA201_1 (RXR-LIKE PROTEIN)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	CYH A 611 ALA A 613 ALA A 614 LEU A 196 LEU A 623	None	0.64A	1xiuA-2g28A: undetectable	1xiuA-2g28A: 15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ZQ9_A_SAMA4000_0 (PROBABLE DIMETHYLADENOSINE TRANSFERASE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	GLY A 732 LEU A 729 LEU A 735 VAL A 822 SER A 649	None	1.14A	1zq9A-2g28A: undetectable	1zq9A-2g28A: 15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2AOI_C_FRDC305_2 (POL POLYPROTEIN PEPTIDE INHIBITOR)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	4 / 5	LEU A 565 PRO A 594 VAL A 516 ILE A 518	None	0.88A	2aoiB-2g28A: undetectable	2aoiB-2g28A: 8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2AVV_E_MK1E902_3 (POL POLYPROTEIN)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	LEU A 565 GLY A 573 PRO A 594 VAL A 516 ILE A 518	None	0.91A	2avvE-2g28A: undetectable	2avvE-2g28A: 8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2CDQ_B_SAMB1500_0 (ASPARTOKINASE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	4 / 7	SER A 753 ARG A 859 LEU A 856 GLU A 861	None	0.94A	2cdqB-2g28A: undetectable	2cdqB-2g28A: 22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2F80_B_017B301_2 (POL POLYPROTEIN)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	LEU A 565 GLY A 573 PRO A 594 VAL A 516 ILE A 518	None	0.76A	2f80B-2g28A: undetectable	2f80B-2g28A: 8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2F81_A_017A302_2 (POL POLYPROTEIN)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	LEU A 565 GLY A 573 PRO A 594 VAL A 516 ILE A 518	None	0.84A	2f81B-2g28A: undetectable	2f81B-2g28A: 8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2F8G_B_017B401_2 (POL POLYPROTEIN)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	LEU A 565 GLY A 573 PRO A 594 VAL A 516 ILE A 518	None	0.74A	2f8gB-2g28A: undetectable	2f8gB-2g28A: 8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2GL0_C_ADNC903_1 (CONSERVED HYPOTHETICAL PROTEIN)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	ILE A 391 THR A 115 ALA A 114 HIS A 364 SER A  83	None	1.40A	2gl0A-2g28A: undetectable 2gl0C-2g28A: undetectable	2gl0A-2g28A: 11.61 2gl0C-2g28A: 11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2GL0_D_ADND904_1 (CONSERVED HYPOTHETICAL PROTEIN)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	HIS A 364 SER A  83 ILE A 391 THR A 115 ALA A 114	None	1.44A	2gl0D-2g28A: undetectable 2gl0E-2g28A: undetectable	2gl0D-2g28A: 11.61 2gl0E-2g28A: 11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HDN_J_TACJ5888_1 (ELONGATION FACTOR EF-TU)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	4 / 6	THR A 631 ASP A 802 SER A 800 VAL A 738	None	1.10A	2hdnI-2g28A: undetectable 2hdnJ-2g28A: undetectable 2hdnL-2g28A: undetectable	2hdnI-2g28A: 3.90 2hdnJ-2g28A: 18.93 2hdnL-2g28A: 18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HDN_L_TACL6888_1 (ELONGATION FACTOR EF-TU)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	4 / 6	SER A 800 VAL A 738 THR A 631 ASP A 802	None	1.16A	2hdnJ-2g28A: undetectable 2hdnK-2g28A: undetectable 2hdnL-2g28A: undetectable	2hdnJ-2g28A: 18.93 2hdnK-2g28A: 3.90 2hdnL-2g28A: 18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HS2_A_017A201_2 (PROTEASE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	LEU A 565 GLY A 573 PRO A 594 VAL A 516 ILE A 518	None	0.94A	2hs2B-2g28A: undetectable	2hs2B-2g28A: 8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2I91_A_ACTA601_0 (60 KDA SS-A/RO RIBONUCLEOPROTEIN)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	4 / 7	ALA A 580 SER A 584 THR A 587 ASN A 588	None	1.00A	2i91A-2g28A: 2.1	2i91A-2g28A: 20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2I91_B_ACTB602_0 (60 KDA SS-A/RO RIBONUCLEOPROTEIN)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	4 / 7	ALA A 580 SER A 584 THR A 587 ASN A 588	None	1.00A	2i91B-2g28A: 2.3	2i91B-2g28A: 20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IEN_B_017B402_2 (PROTEASE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	GLY A 573 ALA A 574 PRO A 594 VAL A 516 ILE A 518	None	0.81A	2ienB-2g28A: undetectable	2ienB-2g28A: 8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IEN_B_017B402_2 (PROTEASE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	LEU A 565 GLY A 573 PRO A 594 VAL A 516 ILE A 518	None	0.77A	2ienB-2g28A: undetectable	2ienB-2g28A: 8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OC8_A_HU5A999_1 (HEPATITIS C VIRUS)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	GLN A 204 LEU A 196 GLY A 200 ALA A 614 ALA A 613	None	0.96A	2oc8A-2g28A: undetectable	2oc8A-2g28A: 12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2P16_A_GG2A298_2 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	3 / 3	ARG A 465 GLU A 185 GLN A 618	None	0.95A	2p16A-2g28A: undetectable	2p16A-2g28A: 13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V0Z_O_C41O1327_2 (RENIN)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	4 / 8	TYR A 596 SER A 493 THR A 494 PRO A 660	None	1.10A	2v0zO-2g28A: undetectable	2v0zO-2g28A: 15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X7H_A_PFNA1375_1 (ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	4 / 5	SER A 760 PHE A 807 VAL A 811 TYR A 658	None	1.40A	2x7hA-2g28A: undetectable	2x7hA-2g28A: 18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X7H_B_PFNB1372_1 (ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	4 / 5	SER A 760 PHE A 807 VAL A 811 TYR A 658	None	1.42A	2x7hB-2g28A: undetectable	2x7hB-2g28A: 18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XZ5_C_ACHC1211_0 (SOLUBLE ACETYLCHOLINE RECEPTOR)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	4 / 8	THR A 651 GLN A 648 TYR A 688 CYH A 655	None	1.25A	2xz5A-2g28A: undetectable 2xz5C-2g28A: undetectable	2xz5A-2g28A: 15.48 2xz5C-2g28A: 15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BGD_B_PM6B302_1 (THIOPURINE S-METHYLTRANSFERASE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	4 / 7	THR A 587 GLN A 222 LEU A 211 LEU A 208	None	0.87A	3bgdB-2g28A: 0.8	3bgdB-2g28A: 15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BVB_B_017B401_1 (PROTEASE (RETROPEPSIN))	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	LEU A 565 GLY A 573 PRO A 594 VAL A 516 ILE A 518	None	0.88A	3bvbA-2g28A: undetectable	3bvbA-2g28A: 8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BVB_B_017B401_2 (PROTEASE (RETROPEPSIN))	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	LEU A 565 GLY A 573 PRO A 594 VAL A 516 ILE A 518	None	0.82A	3bvbB-2g28A: undetectable	3bvbB-2g28A: 8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CYW_A_017A201_1 (HIV-1 PROTEASE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	LEU A 565 GLY A 573 PRO A 594 VAL A 516 ILE A 518	None	0.87A	3cywA-2g28A: undetectable	3cywA-2g28A: 8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CYW_A_017A201_2 (HIV-1 PROTEASE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	LEU A 565 GLY A 573 PRO A 594 VAL A 516 ILE A 518	None	0.74A	3cywB-2g28A: undetectable	3cywB-2g28A: 8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D1X_A_ROCA201_2 (HIV-1 PROTEASE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	LEU A 565 GLY A 573 PRO A 594 VAL A 516 ILE A 518	None	0.89A	3d1xB-2g28A: undetectable	3d1xB-2g28A: 7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D20_A_017A201_2 (HIV-1 PROTEASE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	LEU A 565 GLY A 573 PRO A 594 VAL A 516 ILE A 518	None	0.73A	3d20B-2g28A: undetectable	3d20B-2g28A: 8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DEU_A_SALA305_1 (TRANSCRIPTIONAL REGULATOR SLYA)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 7	VAL A 292 ILE A 369 ILE A 116 SER A 113 THR A 390	None	1.40A	3deuA-2g28A: undetectable	3deuA-2g28A: 11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ETE_A_H3PA552_1 (GLUTAMATE DEHYDROGENASE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	4 / 6	ILE A 624 TYR A 599 MET A 528 ILE A 519	None TDK  A 887 (-4.3A) None None	1.20A	3eteA-2g28A: 3.1 3eteE-2g28A: 2.4	3eteA-2g28A: 21.87 3eteE-2g28A: 21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ETE_C_H3PC554_1 (GLUTAMATE DEHYDROGENASE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	4 / 5	ILE A 624 TYR A 599 MET A 528 ILE A 519	None TDK  A 887 (-4.3A) None None	1.15A	3eteB-2g28A: 2.4 3eteC-2g28A: 3.2	3eteB-2g28A: 21.87 3eteC-2g28A: 21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JW2_A_017A401_1 (GAG-POL POLYPROTEIN)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	LEU A 565 GLY A 573 PRO A 594 VAL A 516 ILE A 518	None	0.85A	3jw2A-2g28A: undetectable	3jw2A-2g28A: 8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KKZ_A_SAMA301_0 (UNCHARACTERIZED PROTEIN Q5LES9)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	GLN A 111 GLY A 397 GLY A 395 SER A 327 ALA A 399	None	1.08A	3kkzA-2g28A: undetectable	3kkzA-2g28A: 14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KKZ_B_SAMB302_0 (UNCHARACTERIZED PROTEIN Q5LES9)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	GLN A 111 GLY A 397 GLY A 395 SER A 327 ALA A 399	None	1.07A	3kkzB-2g28A: undetectable	3kkzB-2g28A: 14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LZS_A_017A200_1 (HIV-1 PROTEASE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	LEU A 565 GLY A 573 PRO A 594 VAL A 516 ILE A 518	None	0.81A	3lzsA-2g28A: undetectable	3lzsA-2g28A: 8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LZS_A_017A200_2 (HIV-1 PROTEASE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	LEU A 565 GLY A 573 PRO A 594 VAL A 516 ILE A 518	None	0.80A	3lzsB-2g28A: undetectable	3lzsB-2g28A: 8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LZU_A_017A200_1 (HIV-1 PROTEASE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	LEU A 565 GLY A 573 PRO A 594 VAL A 516 ILE A 518	None	0.79A	3lzuA-2g28A: undetectable	3lzuA-2g28A: 8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LZU_A_017A200_2 (HIV-1 PROTEASE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	LEU A 565 GLY A 573 PRO A 594 VAL A 516 ILE A 518	None	0.79A	3lzuB-2g28A: undetectable	3lzuB-2g28A: 8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PWM_B_017B402_1 (PROTEASE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	LEU A 565 GLY A 573 PRO A 594 VAL A 516 ILE A 518	None	0.86A	3pwmA-2g28A: undetectable	3pwmA-2g28A: 8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PWM_B_017B402_2 (PROTEASE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	GLY A 573 ALA A 574 PRO A 594 VAL A 516 ILE A 518	None	0.84A	3pwmB-2g28A: undetectable	3pwmB-2g28A: 8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PWM_B_017B402_2 (PROTEASE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	LEU A 565 GLY A 573 PRO A 594 VAL A 516 ILE A 518	None	0.87A	3pwmB-2g28A: undetectable	3pwmB-2g28A: 8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SXJ_A_SAMA258_0 (PUTATIVE METHYLTRANSFERASE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	GLN A 111 GLY A 397 GLY A 395 SER A 327 ALA A 399	None	1.00A	3sxjA-2g28A: 2.3	3sxjA-2g28A: 14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SXJ_B_SAMB258_0 (PUTATIVE METHYLTRANSFERASE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	GLN A 111 GLY A 397 GLY A 395 SER A 327 ALA A 399	None	1.00A	3sxjB-2g28A: undetectable	3sxjB-2g28A: 14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T7S_B_SAMB300_0 (PUTATIVE METHYLTRANSFERASE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	GLN A 111 GLY A 397 GLY A 395 SER A 327 ALA A 399	None	1.14A	3t7sB-2g28A: undetectable	3t7sB-2g28A: 15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T7S_D_SAMD300_0 (PUTATIVE METHYLTRANSFERASE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	GLN A 111 GLY A 397 GLY A 395 SER A 327 ALA A 399	None	1.11A	3t7sD-2g28A: undetectable	3t7sD-2g28A: 15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TKW_B_017B401_2 (PROTEASE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	LEU A 565 GLY A 573 PRO A 594 VAL A 516 ILE A 518	None	0.77A	3tkwB-2g28A: undetectable	3tkwB-2g28A: 8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TL9_A_ROCA401_3 (PROTEASE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	LEU A 565 GLY A 573 PRO A 594 VAL A 516 ILE A 518	None	0.88A	3tl9B-2g28A: undetectable	3tl9B-2g28A: 8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VLN_A_ASCA904_0 (GLUTATHIONE S-TRANSFERASE OMEGA-1)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	4 / 6	LEU A 196 PRO A 198 GLU A 237 SER A 238	None	1.01A	3vlnA-2g28A: undetectable	3vlnA-2g28A: 14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WIP_D_ACHD301_0 (ACETYLCHOLINE-BINDIN G PROTEIN)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	4 / 8	TYR A  59 THR A 390 TYR A 322 TRP A 294	None	1.41A	3wipD-2g28A: undetectable 3wipE-2g28A: undetectable	3wipD-2g28A: 13.96 3wipE-2g28A: 13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A6D_A_SAMA1350_0 (HYDROXYINDOLE O-METHYLTRANSFERASE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	6 / 12	GLY A 363 ILE A 386 VAL A 292 PHE A 227 ALA A 114 ARG A  82	None	0.96A	4a6dA-2g28A: 2.0	4a6dA-2g28A: 18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A6E_A_SAMA1349_0 (HYDROXYINDOLE O-METHYLTRANSFERASE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	6 / 12	GLY A 363 ILE A 386 VAL A 292 PHE A 227 ALA A 114 ARG A  82	None	1.07A	4a6eA-2g28A: undetectable	4a6eA-2g28A: 18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AZS_A_SAMA1475_1 (METHYLTRANSFERASE WBDD)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	3 / 3	ARG A 676 ASP A 770 GLN A 769	None	0.79A	4azsA-2g28A: 3.0	4azsA-2g28A: 21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EIL_A_FOLA703_0 (BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 11	ALA A 245 MET A 233 LEU A 278 VAL A 385 THR A 246	None	1.41A	4eilA-2g28A: undetectable	4eilA-2g28A: 19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EIL_C_FOLC703_0 (BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 11	ALA A 245 MET A 233 LEU A 278 VAL A 385 THR A 246	None	1.41A	4eilC-2g28A: undetectable	4eilC-2g28A: 19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EIL_E_FOLE703_0 (BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 11	ALA A 245 MET A 233 LEU A 278 VAL A 385 THR A 246	None	1.40A	4eilE-2g28A: undetectable	4eilE-2g28A: 19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EOH_A_TEPA402_1 (PYRIDOXAL KINASE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	4 / 5	SER A 733 GLY A 732 THR A 825 ASP A 659	None	0.91A	4eohA-2g28A: undetectable	4eohA-2g28A: 16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FP9_D_SAMD401_1 (METHYLTRANSFERASE NSUN4)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	3 / 3	ASP A 819 ARG A 859 ASP A 794	None	0.82A	4fp9D-2g28A: undetectable	4fp9D-2g28A: 17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HLA_A_017A200_1 (PROTEASE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	LEU A 565 GLY A 573 PRO A 594 VAL A 516 ILE A 518	None	0.87A	4hlaA-2g28A: undetectable	4hlaA-2g28A: 7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HLA_A_017A200_2 (PROTEASE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 11	LEU A 565 GLY A 573 PRO A 594 VAL A 516 ILE A 518	None	0.93A	4hlaB-2g28A: undetectable	4hlaB-2g28A: 7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IIL_A_RBFA401_1 (MEMBRANE LIPOPROTEIN TPN38(B))	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	TYR A 598 TYR A 686 ILE A 652 TRP A 578 GLY A 575	None	1.48A	4iilA-2g28A: 2.8	4iilA-2g28A: 17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4JVL_A_ESTA702_1 (ESTROGEN SULFOTRANSFERASE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	4 / 9	TYR A 117 PHE A 125 CYH A 120 ILE A 386	None	0.98A	4jvlA-2g28A: undetectable	4jvlA-2g28A: 15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KMU_C_RFPC1401_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	GLN A 617 GLN A 188 ARG A 128 SER A 586 ASN A 588	None	1.43A	4kmuC-2g28A: 0.0	4kmuC-2g28A: 21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KN2_B_LYAB304_1 (FOLATE RECEPTOR BETA)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	THR A 495 ARG A 630 GLY A 637 SER A 733 TYR A 696	None	1.28A	4kn2B-2g28A: 0.0	4kn2B-2g28A: 12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KYA_A_FOLA703_0 (BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 11	ALA A 245 MET A 233 LEU A 278 VAL A 385 THR A 246	None	1.40A	4kyaA-2g28A: undetectable	4kyaA-2g28A: 19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KYA_C_FOLC703_0 (BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 10	ALA A 245 MET A 233 LEU A 278 VAL A 385 THR A 246	None	1.42A	4kyaC-2g28A: undetectable	4kyaC-2g28A: 19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KYA_E_FOLE703_0 (BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 11	ALA A 245 MET A 233 LEU A 278 VAL A 385 THR A 246	None	1.42A	4kyaE-2g28A: 2.2	4kyaE-2g28A: 19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KYA_G_FOLG703_0 (BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 11	ALA A 245 MET A 233 LEU A 278 VAL A 385 THR A 246	None	1.41A	4kyaG-2g28A: undetectable	4kyaG-2g28A: 19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OU1_A_BEZA302_0 (RETRO-ALDOLASE, DESIGN RA114)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	4 / 8	ILE A  85 ASN A  88 ALA A 149 TRP A  87	None	0.93A	4ou1A-2g28A: undetectable	4ou1A-2g28A: 15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QB9_F_PARF500_1 (ENHANCED INTRACELLULAR SURVIVAL PROTEIN)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 11	PHE A 807 SER A 657 GLU A 522 TYR A 598 GLY A 625	None None TDK  A 887 (-4.3A) None None	1.20A	4qb9F-2g28A: undetectable	4qb9F-2g28A: 18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVL_B_BO2B201_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-1)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 11	THR A 494 THR A 495 ARG A 838 GLY A 629 THR A 631	None	1.34A	4qvlV-2g28A: undetectable 4qvlb-2g28A: undetectable	4qvlV-2g28A: 13.96 4qvlb-2g28A: 12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVL_N_BO2N201_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-1)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 11	THR A 494 THR A 495 ARG A 838 GLY A 629 THR A 631	None	1.34A	4qvlH-2g28A: undetectable 4qvlN-2g28A: undetectable	4qvlH-2g28A: 13.96 4qvlN-2g28A: 12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVM_B_BO2B201_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-1)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 11	THR A 494 THR A 495 ARG A 838 GLY A 629 THR A 631	None	1.33A	4qvmV-2g28A: undetectable 4qvmb-2g28A: undetectable	4qvmV-2g28A: 13.96 4qvmb-2g28A: 12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVM_N_BO2N201_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-1)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 11	THR A 494 THR A 495 ARG A 838 GLY A 629 THR A 631	None	1.33A	4qvmH-2g28A: undetectable 4qvmN-2g28A: undetectable	4qvmH-2g28A: 13.96 4qvmN-2g28A: 12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVP_B_BO2B201_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-1)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 11	THR A 494 THR A 495 ARG A 838 GLY A 629 THR A 631	None	1.34A	4qvpV-2g28A: undetectable 4qvpb-2g28A: undetectable	4qvpV-2g28A: 13.96 4qvpb-2g28A: 12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVP_N_BO2N201_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-1)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 11	THR A 494 THR A 495 ARG A 838 GLY A 629 THR A 631	None	1.34A	4qvpH-2g28A: undetectable 4qvpN-2g28A: undetectable	4qvpH-2g28A: 13.96 4qvpN-2g28A: 12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVQ_B_BO2B201_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-1)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 11	THR A 494 THR A 495 ARG A 838 GLY A 629 THR A 631	None	1.35A	4qvqV-2g28A: undetectable 4qvqb-2g28A: undetectable	4qvqV-2g28A: 13.96 4qvqb-2g28A: 12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVQ_N_BO2N201_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-1)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 11	THR A 494 THR A 495 ARG A 838 GLY A 629 THR A 631	None	1.35A	4qvqH-2g28A: undetectable 4qvqN-2g28A: undetectable	4qvqH-2g28A: 13.96 4qvqN-2g28A: 12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVW_B_BO2B201_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-1)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 11	THR A 494 THR A 495 ARG A 838 GLY A 629 THR A 631	None	1.34A	4qvwV-2g28A: undetectable 4qvwb-2g28A: undetectable	4qvwV-2g28A: 13.96 4qvwb-2g28A: 12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVW_N_BO2N201_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-1)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 11	THR A 494 THR A 495 ARG A 838 GLY A 629 THR A 631	None	1.34A	4qvwH-2g28A: undetectable 4qvwN-2g28A: undetectable	4qvwH-2g28A: 13.96 4qvwN-2g28A: 12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QW0_B_BO2B201_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-1)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 11	THR A 494 THR A 495 ARG A 838 GLY A 629 THR A 631	None	1.33A	4qw0V-2g28A: undetectable 4qw0b-2g28A: undetectable	4qw0V-2g28A: 13.96 4qw0b-2g28A: 12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QW0_N_BO2N201_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-1)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 11	THR A 494 THR A 495 ARG A 838 GLY A 629 THR A 631	None	1.32A	4qw0H-2g28A: undetectable 4qw0N-2g28A: undetectable	4qw0H-2g28A: 13.96 4qw0N-2g28A: 12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QW1_B_BO2B201_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-1)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 11	THR A 494 THR A 495 ARG A 838 GLY A 629 THR A 631	None	1.36A	4qw1V-2g28A: undetectable 4qw1b-2g28A: undetectable	4qw1V-2g28A: 13.96 4qw1b-2g28A: 12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QW1_N_BO2N201_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-1)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 11	THR A 494 THR A 495 ARG A 838 GLY A 629 THR A 631	None	1.36A	4qw1H-2g28A: undetectable 4qw1N-2g28A: undetectable	4qw1H-2g28A: 13.96 4qw1N-2g28A: 12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QW3_B_BO2B201_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-1)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 11	THR A 494 THR A 495 ARG A 838 GLY A 629 THR A 631	None	1.34A	4qw3V-2g28A: undetectable 4qw3b-2g28A: undetectable	4qw3V-2g28A: 13.96 4qw3b-2g28A: 12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QW3_N_BO2N201_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-1)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 11	THR A 494 THR A 495 ARG A 838 GLY A 629 THR A 631	None	1.34A	4qw3H-2g28A: undetectable 4qw3N-2g28A: undetectable	4qw3H-2g28A: 13.96 4qw3N-2g28A: 12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QWU_B_BO2B201_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-1)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 11	THR A 494 THR A 495 ARG A 838 GLY A 629 THR A 631	None	1.39A	4qwuV-2g28A: undetectable 4qwub-2g28A: undetectable	4qwuV-2g28A: 13.96 4qwub-2g28A: 12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QWU_N_BO2N201_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-1)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 11	THR A 494 THR A 495 ARG A 838 GLY A 629 THR A 631	None	1.39A	4qwuH-2g28A: undetectable 4qwuN-2g28A: undetectable	4qwuH-2g28A: 13.96 4qwuN-2g28A: 12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YV5_B_SVRB207_2 (BASIC PHOSPHOLIPASE A2 HOMOLOG 2)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	4 / 7	ASN A 695 TYR A 662 TYR A 664 LEU A 484	None	0.93A	4yv5B-2g28A: undetectable	4yv5B-2g28A: 8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BXN_B_BO2B201_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-1)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 11	THR A 494 THR A 495 ARG A 838 GLY A 629 THR A 631	None	1.36A	5bxnV-2g28A: undetectable 5bxnb-2g28A: undetectable	5bxnV-2g28A: 13.84 5bxnb-2g28A: 12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BXN_N_BO2N201_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-1)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 11	THR A 494 THR A 495 ARG A 838 GLY A 629 THR A 631	None	1.35A	5bxnH-2g28A: undetectable 5bxnN-2g28A: undetectable	5bxnH-2g28A: 13.84 5bxnN-2g28A: 12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CZ7_N_BO2N201_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-1)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 11	THR A 494 THR A 495 ARG A 838 GLY A 629 THR A 631	None	1.35A	5cz7H-2g28A: undetectable 5cz7N-2g28A: undetectable	5cz7H-2g28A: 13.96 5cz7N-2g28A: 12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CZY_A_SAMA603_0 (LEGIONELLA EFFECTOR LEGAS4)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	LEU A 531 GLY A 530 ARG A 533 ASN A 503 LEU A 506	None	1.34A	5czyA-2g28A: undetectable	5czyA-2g28A: 19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5D0X_B_BO2B201_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-1)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 11	THR A 494 THR A 495 ARG A 838 GLY A 629 THR A 631	None	1.33A	5d0xV-2g28A: undetectable 5d0xb-2g28A: undetectable	5d0xV-2g28A: 13.96 5d0xb-2g28A: 12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5D0X_N_BO2N201_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-1)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 11	THR A 494 THR A 495 ARG A 838 GLY A 629 THR A 631	None	1.33A	5d0xH-2g28A: undetectable 5d0xN-2g28A: undetectable	5d0xH-2g28A: 13.96 5d0xN-2g28A: 12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ESG_A_1YNA701_2 (LANOSTEROL 14-ALPHA DEMETHYLASE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	4 / 4	LEU A 502 TYR A 687 PRO A 594 ILE A 518	None	1.40A	5esgA-2g28A: undetectable	5esgA-2g28A: 20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EWU_A_BEZA1401_0 (MAGNESIUM-CHELATASE SUBUNIT CHLH, CHLOROPLASTIC)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	4 / 6	GLY A 824 THR A 825 SER A 800 VAL A 843	None	0.86A	5ewuA-2g28A: 1.5	5ewuA-2g28A: 19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EWU_B_BEZB1401_0 (MAGNESIUM-CHELATASE SUBUNIT CHLH, CHLOROPLASTIC)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	4 / 6	GLY A 824 THR A 825 SER A 800 VAL A 843	None	1.02A	5ewuB-2g28A: undetectable	5ewuB-2g28A: 19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5F1A_A_SALA601_1 (PROSTAGLANDIN G/H SYNTHASE 2)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	4 / 8	LEU A 610 GLY A 575 ALA A 574 SER A 577	None	0.82A	5f1aA-2g28A: undetectable	5f1aA-2g28A: 21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5F1A_B_SALB601_1 (PROSTAGLANDIN G/H SYNTHASE 2)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	4 / 7	LEU A 610 GLY A 575 ALA A 574 SER A 577	None	0.82A	5f1aB-2g28A: undetectable	5f1aB-2g28A: 21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5FEP_A_SAMA407_0 ([FEFE] HYDROGENASE MATURASE SUBUNIT HYDE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	SER A 760 GLY A 712 LEU A 764 ARG A 766 TYR A 687	None	1.14A	5fepA-2g28A: 0.3	5fepA-2g28A: 17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5FES_A_SAMA408_0 ([FEFE] HYDROGENASE MATURASE SUBUNIT HYDE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	SER A 760 GLY A 712 LEU A 764 ARG A 766 TYR A 687	None	1.14A	5fesA-2g28A: 0.4	5fesA-2g28A: 17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5G48_A_1FLA1375_1 (DNA POLYMERASE III SUBUNIT BETA)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	4 / 8	THR A 246 LEU A 250 ILE A 202 LEU A 253	None	0.89A	5g48A-2g28A: undetectable	5g48A-2g28A: 18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JSD_A_1GNA607_1 (PHIAB6 TAILSPIKE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	3 / 3	THR A 494 SER A 493 TYR A 696	None	0.79A	5jsdA-2g28A: undetectable	5jsdA-2g28A: 21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JSD_B_1GNB618_1 (PHIAB6 TAILSPIKE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	3 / 3	THR A 494 SER A 493 TYR A 696	None	0.79A	5jsdB-2g28A: undetectable	5jsdB-2g28A: 21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JSD_C_1GNC608_1 (PHIAB6 TAILSPIKE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	3 / 3	THR A 494 SER A 493 TYR A 696	None	0.79A	5jsdC-2g28A: undetectable	5jsdC-2g28A: 21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JSE_A_1GNA608_1 (PHIAB6 TAILSPIKE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	3 / 3	THR A 494 SER A 493 TYR A 696	None	0.79A	5jseA-2g28A: undetectable	5jseA-2g28A: 21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JSE_B_1GNB611_1 (PHIAB6 TAILSPIKE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	3 / 3	THR A 494 SER A 493 TYR A 696	None	0.78A	5jseB-2g28A: undetectable	5jseB-2g28A: 21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JSE_C_1GNC611_1 (PHIAB6 TAILSPIKE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	3 / 3	THR A 494 SER A 493 TYR A 696	None	0.78A	5jseC-2g28A: undetectable	5jseC-2g28A: 21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L5Z_B_BO2B201_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-1)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	THR A 494 THR A 495 ARG A 838 GLY A 629 THR A 631	None	1.35A	5l5zV-2g28A: undetectable 5l5zb-2g28A: undetectable	5l5zV-2g28A: 13.96 5l5zb-2g28A: 12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L66_B_BO2B201_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-1)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 11	THR A 494 THR A 495 ARG A 838 GLY A 629 THR A 631	None	1.35A	5l66V-2g28A: undetectable 5l66b-2g28A: undetectable	5l66V-2g28A: 13.96 5l66b-2g28A: 12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L66_N_BO2N201_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-1)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 11	THR A 494 THR A 495 ARG A 838 GLY A 629 THR A 631	None	1.35A	5l66H-2g28A: undetectable 5l66N-2g28A: undetectable	5l66H-2g28A: 13.96 5l66N-2g28A: 12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LAK_I_BEZI1_0 (3CL PROTEASE BEZ-TYR-TYR-ASN-ECC PEPTIDE INHIBITOR)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	3 / 3	SER A 600 TYR A 599 TYR A 598	None TDK  A 887 (-4.3A) None	0.53A	5lakA-2g28A: undetectable 5lakI-2g28A: undetectable	5lakA-2g28A: 16.07 5lakI-2g28A: 0.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LAK_J_BEZJ1_0 (3CL PROTEASE BEZ-TYR-TYR-ASN-ECC PEPTIDE INHIBITOR)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	3 / 3	SER A 600 TYR A 599 TYR A 598	None TDK  A 887 (-4.3A) None	0.54A	5lakC-2g28A: undetectable 5lakJ-2g28A: undetectable	5lakC-2g28A: 16.07 5lakJ-2g28A: 0.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MRA_B_DM2B204_1 (SORCIN)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	4 / 6	THR A 762 ARG A 766 ASP A 767 GLY A 768	None	1.17A	5mraA-2g28A: undetectable 5mraB-2g28A: undetectable	5mraA-2g28A: 10.95 5mraB-2g28A: 10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NFJ_B_SAMB501_0 (MITOCHONDRIAL RIBONUCLEASE P PROTEIN 1)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	LEU A 531 ILE A 564 GLY A 536 LEU A 502 LEU A 515	None	1.03A	5nfjB-2g28A: undetectable	5nfjB-2g28A: 12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NFJ_C_SAMC501_0 (MITOCHONDRIAL RIBONUCLEASE P PROTEIN 1)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	LEU A 531 ILE A 564 GLY A 536 LEU A 502 LEU A 515	None	1.02A	5nfjC-2g28A: undetectable	5nfjC-2g28A: 12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TWJ_A_SAMA201_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE H)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	LEU A 531 ILE A 564 GLY A 536 LEU A 502 LEU A 515	None	1.00A	5twjA-2g28A: undetectable	5twjA-2g28A: 10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TWJ_B_SAMB201_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE H)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 10	LEU A 531 ILE A 564 GLY A 536 LEU A 502 LEU A 515	None	1.04A	5twjB-2g28A: undetectable	5twjB-2g28A: 10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UMW_B_RBFB201_1 (GLYOXALASE/BLEOMYCIN RESISANCE PROTEIN/DIOXYGENASE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	4 / 7	VAL A 668 TYR A 714 GLU A 665 LEU A 764	None	1.20A	5umwB-2g28A: undetectable 5umwE-2g28A: undetectable	5umwB-2g28A: 7.62 5umwE-2g28A: 7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5V5Z_A_1YNA602_1 (LANOSTEROL 14-ALPHA DEMETHYLASE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	TYR A 598 ILE A 518 TYR A 596 GLY A 621 HIS A 646	None	1.37A	5v5zA-2g28A: undetectable	5v5zA-2g28A: 20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X7P_B_ACRB1471_1 (GLYCOSIDE HYDROLASE FAMILY 31 ALPHA-GLUCOSIDASE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	ARG A 834 ASP A 659 GLY A 732 TYR A 803 THR A 825	None	1.05A	5x7pB-2g28A: 0.4	5x7pB-2g28A: 21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DGX_A_017A101_0 (PROTEASE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	GLY A 573 ALA A 574 PRO A 594 VAL A 516 ILE A 518	None	0.85A	6dgxA-2g28A: undetectable	6dgxA-2g28A: 7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DGX_A_017A101_0 (PROTEASE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	LEU A 565 GLY A 573 PRO A 594 VAL A 516 ILE A 518	None	0.84A	6dgxA-2g28A: undetectable	6dgxA-2g28A: 7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DIF_B_TPVB201_1 (HIV-1 PROTEASE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	GLY A 573 ALA A 574 PRO A 594 VAL A 516 ILE A 518	None	0.74A	6difB-2g28A: undetectable	6difB-2g28A: 7.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DIF_B_TPVB201_1 (HIV-1 PROTEASE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	LEU A 565 GLY A 573 PRO A 594 VAL A 516 ILE A 518	None	0.76A	6difB-2g28A: undetectable	6difB-2g28A: 7.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DIL_B_TPVB201_1 (HIV-1 PROTEASE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 12	GLY A 573 ALA A 574 PRO A 594 VAL A 516 ILE A 518	None	0.79A	6dilB-2g28A: undetectable	6dilB-2g28A: 6.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EBZ_A_DAHA123_0 (RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE, BETA SUBUNIT)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 11	PHE A 532 LEU A 531 GLY A 562 ILE A 537 ILE A 519	None	0.97A	6ebzA-2g28A: undetectable	6ebzA-2g28A: 7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EBZ_C_DAHC123_0 (RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE, BETA SUBUNIT)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 11	PHE A 532 LEU A 531 GLY A 562 ILE A 537 ILE A 519	None	1.02A	6ebzC-2g28A: undetectable	6ebzC-2g28A: 7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GP2_A_DAHA126_0 (RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE BETA CHAIN)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 11	PHE A 532 LEU A 531 GLY A 562 ILE A 537 ILE A 519	None	0.97A	6gp2A-2g28A: undetectable	6gp2A-2g28A: 9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GP2_B_DAHB126_0 (RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE BETA CHAIN)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	5 / 11	PHE A 532 LEU A 531 GLY A 562 ILE A 537 ILE A 519	None	0.99A	6gp2B-2g28A: undetectable	6gp2B-2g28A: 9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HIS_A_TKTA508_0 (5-HYDROXYTRYPTAMINE RECEPTOR 3A)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	4 / 8	ASP A 422 ILE A 420 ARG A 421 ASN A  88	None	1.23A	6hisA-2g28A: 2.1 6hisB-2g28A: 2.1	6hisA-2g28A: 6.41 6hisB-2g28A: 6.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HIS_B_TKTB508_0 (5-HYDROXYTRYPTAMINE RECEPTOR 3A)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	4 / 8	ASP A 422 ILE A 420 ARG A 421 ASN A  88	None	1.24A	6hisB-2g28A: 2.1 6hisC-2g28A: 2.1	6hisB-2g28A: 6.41 6hisC-2g28A: 6.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HIS_C_TKTC508_0 (5-HYDROXYTRYPTAMINE RECEPTOR 3A)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	4 / 8	ASP A 422 ILE A 420 ARG A 421 ASN A  88	None	1.24A	6hisC-2g28A: 2.1 6hisD-2g28A: 2.1	6hisC-2g28A: 6.41 6hisD-2g28A: 6.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HIS_D_TKTD501_0 (5-HYDROXYTRYPTAMINE RECEPTOR 3A)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	4 / 8	ASP A 422 ILE A 420 ARG A 421 ASN A  88	None	1.23A	6hisD-2g28A: 2.1 6hisE-2g28A: 2.1	6hisD-2g28A: 6.41 6hisE-2g28A: 6.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HIS_E_TKTE501_0 (5-HYDROXYTRYPTAMINE RECEPTOR 3A)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	4 / 8	ASN A  88 ASP A 422 ILE A 420 ARG A 421	None	1.25A	6hisA-2g28A: 2.1 6hisE-2g28A: 2.1	6hisA-2g28A: 6.41 6hisE-2g28A: 6.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HU9_E_PCFE202_0 (CYTOCHROME C OXIDASE POLYPEPTIDE 5A, MITOCHONDRIAL CYTOCHROME C OXIDASE SUBUNIT 1)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	4 / 8	GLN A 159 VAL A  93 ARG A  95 MET A  91	None	1.07A	6hu9a-2g28A: undetectable 6hu9e-2g28A: undetectable	6hu9a-2g28A: 18.54 6hu9e-2g28A: 9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6NCS_A_ACTA303_0 (N-ACETYLNEURAMINIC ACID (SIALIC ACID) SYNTHETASE)	2g28	PYRUVATE DEHYDROGENASE E1 COMPONENT (Escherichia coli)	3 / 3	ILE A 439 THR A 440 PRO A 427	None	0.54A	6ncsA-2g28A: undetectable	6ncsA-2g28A: 14.89