SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2g2d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 2g2d ATP:COBALAMIN
ADENOSYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 8 ARG A 164
ALA A  73
ILE A  66
ILE A  97
ILE A  92
 None
 1.48A 1hshD-2g2dA:
undetectable		 1hshD-2g2dA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2g2d ATP:COBALAMIN
ADENOSYLTRANSFERASE
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 125
PRO A 124
LEU A 128
 None
 0.63A 2po5B-2g2dA:
undetectable		 2po5B-2g2dA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 2g2d ATP:COBALAMIN
ADENOSYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 9 ALA A  45
GLY A  47
LEU A  70
LEU A  50
ILE A  66
 None
 1.19A 3wdmC-2g2dA:
undetectable		 3wdmC-2g2dA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 2g2d ATP:COBALAMIN
ADENOSYLTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 6 VAL A 175
LEU A 125
LEU A 129
HIS A 130
 None
 1.02A 6e43B-2g2dA:
2.0		 6e43B-2g2dA:
20.76