SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2g2o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)		 2g2o MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Escherichia
coli) 		4 / 8 GLN A  63
LEU A  67
LEU A  44
TYR A  42
 SO4  A1001 (-3.9A)
None
None
None
 1.16A 1hk2A-2g2oA:
1.4		 1hk2A-2g2oA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)		 2g2o MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Escherichia
coli) 		4 / 6 ALA A 144
ILE A 169
VAL A 167
PHE A 161
 None
 0.87A 2cizA-2g2oA:
undetectable		 2cizA-2g2oA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2g2o MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Escherichia
coli) 		4 / 7 LEU A  44
PHE A  33
THR A  15
LEU A  56
 None
 1.01A 2eikA-2g2oA:
undetectable
2eikJ-2g2oA:
undetectable		 2eikA-2g2oA:
22.25
2eikJ-2g2oA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2g2o MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Escherichia
coli) 		4 / 8 LEU A  44
PHE A  33
THR A  15
LEU A  56
 None
 0.91A 2einA-2g2oA:
undetectable
2einJ-2g2oA:
undetectable		 2einA-2g2oA:
22.25
2einJ-2g2oA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 2g2o MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Escherichia
coli) 		5 / 11 SER A  97
LEU A  44
PHE A  33
GLU A 274
LEU A  19
 None
 1.26A 2v0mD-2g2oA:
undetectable		 2v0mD-2g2oA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 2g2o MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Escherichia
coli) 		5 / 11 ALA A   5
ALA A 102
LEU A 297
TYR A  74
PHE A   8
 None
 1.21A 3rc0A-2g2oA:
undetectable		 3rc0A-2g2oA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)		 2g2o MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Escherichia
coli) 		4 / 8 PHE A   8
PHE A 107
ALA A  72
THR A  32
 None
 1.04A 3t3sE-2g2oA:
undetectable		 3t3sE-2g2oA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2g2o MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Escherichia
coli) 		6 / 10 SER A 142
ALA A 146
ILE A 169
VAL A 167
ALA A 188
ILE A 135
 None
 1.24A 4lbgA-2g2oA:
undetectable		 4lbgA-2g2oA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2g2o MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Escherichia
coli) 		5 / 12 VAL A 275
TRP A  45
PHE A  33
LEU A  67
VAL A  29
 None
 1.31A 4nc3A-2g2oA:
undetectable		 4nc3A-2g2oA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 2g2o MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Escherichia
coli) 		4 / 8 ALA A 223
ALA A 242
ILE A 243
GLU A 237
 None
 0.58A 5mvmA-2g2oA:
undetectable
5mvmB-2g2oA:
1.8		 5mvmA-2g2oA:
15.52
5mvmB-2g2oA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 2g2o MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Escherichia
coli) 		4 / 7 VAL A 100
VAL A 228
GLY A  94
TYR A  96
 None
 1.01A 5x80C-2g2oA:
undetectable
5x80D-2g2oA:
undetectable		 5x80C-2g2oA:
22.88
5x80D-2g2oA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2g2o MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Escherichia
coli) 		4 / 8 LEU A  44
PHE A  33
THR A  15
LEU A  56
 None
 0.95A 5zcoA-2g2oA:
undetectable
5zcoJ-2g2oA:
undetectable		 5zcoA-2g2oA:
22.25
5zcoJ-2g2oA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 2g2o MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Escherichia
coli) 		4 / 8 LEU A  47
LEU A  44
GLY A 118
ARG A 117
 None
None
None
SO4  A1001 (-2.9A)
 0.85A 6ce2A-2g2oA:
undetectable		 6ce2A-2g2oA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)		 2g2o MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Escherichia
coli) 		5 / 12 VAL A 100
LEU A  44
ALA A 110
GLN A  14
LEU A  93
 None
None
None
None
SO4  A1001 (-4.3A)
 1.12A 6ew0B-2g2oA:
undetectable		 6ew0B-2g2oA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)		 2g2o MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Escherichia
coli) 		5 / 12 VAL A 100
LEU A  44
ALA A 110
GLN A  14
LEU A  93
 None
None
None
None
SO4  A1001 (-4.3A)
 1.12A 6ew0D-2g2oA:
undetectable		 6ew0D-2g2oA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_1
(TUBULIN BETA CHAIN)		 2g2o MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Escherichia
coli) 		5 / 12 VAL A 100
LEU A  44
ALA A 110
GLN A  14
LEU A  93
 None
None
None
None
SO4  A1001 (-4.3A)
 1.12A 6ew0F-2g2oA:
undetectable		 6ew0F-2g2oA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		 2g2o MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Escherichia
coli) 		5 / 12 VAL A 100
LEU A  44
ALA A 110
GLN A  14
LEU A  93
 None
None
None
None
SO4  A1001 (-4.3A)
 1.12A 6ew0G-2g2oA:
undetectable		 6ew0G-2g2oA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)		 2g2o MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Escherichia
coli) 		5 / 12 VAL A 100
LEU A  44
ALA A 110
GLN A  14
LEU A  93
 None
None
None
None
SO4  A1001 (-4.3A)
 1.12A 6ew0H-2g2oA:
undetectable		 6ew0H-2g2oA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)		 2g2o MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Escherichia
coli) 		5 / 12 VAL A 100
LEU A  44
ALA A 110
GLN A  14
LEU A  93
 None
None
None
None
SO4  A1001 (-4.3A)
 1.12A 6ew0I-2g2oA:
undetectable		 6ew0I-2g2oA:
18.40