SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2g36'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
4 / 8 ALA A 134
ILE A 128
ILE A  97
ILE A 161
None
0.65A 1hshD-2g36A:
undetectable
1hshD-2g36A:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
3 / 3 GLU A 234
ASN A 232
TRP A 256
None
1.31A 1r15C-2g36A:
undetectable
1r15C-2g36A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
3 / 3 GLU A 234
ASN A 232
TRP A 256
None
1.29A 1r15D-2g36A:
undetectable
1r15D-2g36A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
3 / 3 GLU A 234
ASN A 232
TRP A 256
None
1.30A 1r15E-2g36A:
undetectable
1r15E-2g36A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
4 / 7 TRP A 256
ASP A 229
TRP A 239
HIS A 242
None
1.48A 1v54A-2g36A:
undetectable
1v54C-2g36A:
undetectable
1v54A-2g36A:
20.08
1v54C-2g36A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
4 / 7 TRP A 256
ASP A 229
TRP A 239
HIS A 242
None
1.50A 1v54N-2g36A:
undetectable
1v54P-2g36A:
undetectable
1v54N-2g36A:
20.08
1v54P-2g36A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
4 / 7 TRP A 256
ASP A 229
TRP A 239
HIS A 242
None
1.48A 2dyrA-2g36A:
undetectable
2dyrC-2g36A:
undetectable
2dyrA-2g36A:
20.08
2dyrC-2g36A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
4 / 7 TRP A 256
ASP A 229
TRP A 239
HIS A 242
None
1.50A 2dyrN-2g36A:
undetectable
2dyrP-2g36A:
undetectable
2dyrN-2g36A:
20.08
2dyrP-2g36A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
4 / 7 TRP A 256
ASP A 229
TRP A 239
HIS A 242
None
1.48A 2eijA-2g36A:
undetectable
2eijC-2g36A:
undetectable
2eijA-2g36A:
20.08
2eijC-2g36A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
4 / 7 TRP A 256
ASP A 229
TRP A 239
HIS A 242
None
1.49A 2eikA-2g36A:
undetectable
2eikC-2g36A:
undetectable
2eikA-2g36A:
20.08
2eikC-2g36A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
4 / 7 TRP A 256
ASP A 229
TRP A 239
HIS A 242
None
1.50A 2eikN-2g36A:
undetectable
2eikP-2g36A:
undetectable
2eikN-2g36A:
20.08
2eikP-2g36A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
4 / 7 TRP A 256
ASP A 229
TRP A 239
HIS A 242
None
1.47A 2eilA-2g36A:
undetectable
2eilC-2g36A:
undetectable
2eilA-2g36A:
20.08
2eilC-2g36A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
4 / 7 TRP A 256
ASP A 229
TRP A 239
HIS A 242
None
1.48A 2eilN-2g36A:
undetectable
2eilP-2g36A:
undetectable
2eilN-2g36A:
20.08
2eilP-2g36A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
4 / 7 TRP A 256
ASP A 229
TRP A 239
HIS A 242
None
1.43A 3abkN-2g36A:
undetectable
3abkP-2g36A:
undetectable
3abkN-2g36A:
20.08
3abkP-2g36A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
4 / 7 TRP A 256
ASP A 229
TRP A 239
HIS A 242
None
1.49A 3ag3A-2g36A:
undetectable
3ag3C-2g36A:
undetectable
3ag3A-2g36A:
20.08
3ag3C-2g36A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
4 / 7 TRP A 256
ASP A 229
TRP A 239
HIS A 242
None
1.49A 3ag3N-2g36A:
undetectable
3ag3P-2g36A:
undetectable
3ag3N-2g36A:
20.08
3ag3P-2g36A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
4 / 7 TRP A 256
ASP A 229
TRP A 239
HIS A 242
None
1.49A 3ag4A-2g36A:
undetectable
3ag4C-2g36A:
undetectable
3ag4A-2g36A:
20.08
3ag4C-2g36A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
4 / 7 TRP A 256
ASP A 229
TRP A 239
HIS A 242
None
1.50A 3ag4N-2g36A:
undetectable
3ag4P-2g36A:
undetectable
3ag4N-2g36A:
20.08
3ag4P-2g36A:
20.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FHJ_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
7 / 10 GLY A   6
HIS A  43
ASP A 136
ILE A 137
VAL A 145
VAL A 147
GLN A 151
TRP  A 401 (-4.1A)
TRP  A 401 (-3.9A)
TRP  A 401 (-3.8A)
TRP  A 401 (-4.9A)
TRP  A 401 (-4.7A)
None
TRP  A 401 (-3.5A)
0.61A 3fhjA-2g36A:
32.7
3fhjA-2g36A:
37.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FHJ_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
7 / 10 GLY A   6
HIS A  43
ASP A 136
ILE A 137
VAL A 145
VAL A 147
GLN A 151
TRP  A 401 (-4.1A)
TRP  A 401 (-3.9A)
TRP  A 401 (-3.8A)
TRP  A 401 (-4.9A)
TRP  A 401 (-4.7A)
None
TRP  A 401 (-3.5A)
0.61A 3fhjB-2g36A:
31.5
3fhjB-2g36A:
37.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FHJ_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
7 / 10 GLY A   6
HIS A  43
ASP A 136
ILE A 137
VAL A 145
VAL A 147
GLN A 151
TRP  A 401 (-4.1A)
TRP  A 401 (-3.9A)
TRP  A 401 (-3.8A)
TRP  A 401 (-4.9A)
TRP  A 401 (-4.7A)
None
TRP  A 401 (-3.5A)
0.61A 3fhjC-2g36A:
31.5
3fhjC-2g36A:
37.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FHJ_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
7 / 9 GLY A   6
HIS A  43
ASP A 136
ILE A 137
VAL A 145
VAL A 147
GLN A 151
TRP  A 401 (-4.1A)
TRP  A 401 (-3.9A)
TRP  A 401 (-3.8A)
TRP  A 401 (-4.9A)
TRP  A 401 (-4.7A)
None
TRP  A 401 (-3.5A)
0.61A 3fhjD-2g36A:
32.7
3fhjD-2g36A:
37.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FHJ_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
7 / 10 GLY A   6
HIS A  43
ASP A 136
ILE A 137
VAL A 145
VAL A 147
GLN A 151
TRP  A 401 (-4.1A)
TRP  A 401 (-3.9A)
TRP  A 401 (-3.8A)
TRP  A 401 (-4.9A)
TRP  A 401 (-4.7A)
None
TRP  A 401 (-3.5A)
0.61A 3fhjE-2g36A:
32.7
3fhjE-2g36A:
37.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FHJ_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
7 / 9 GLY A   6
HIS A  43
ASP A 136
ILE A 137
VAL A 145
VAL A 147
GLN A 151
TRP  A 401 (-4.1A)
TRP  A 401 (-3.9A)
TRP  A 401 (-3.8A)
TRP  A 401 (-4.9A)
TRP  A 401 (-4.7A)
None
TRP  A 401 (-3.5A)
0.61A 3fhjF-2g36A:
33.2
3fhjF-2g36A:
37.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
7 / 9 GLY A   6
HIS A  43
ASP A 136
ILE A 137
VAL A 145
VAL A 147
GLN A 151
TRP  A 401 (-4.1A)
TRP  A 401 (-3.9A)
TRP  A 401 (-3.8A)
TRP  A 401 (-4.9A)
TRP  A 401 (-4.7A)
None
TRP  A 401 (-3.5A)
0.69A 3fi0A-2g36A:
32.8
3fi0A-2g36A:
37.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
7 / 8 GLY A   6
HIS A  43
ASP A 136
ILE A 137
VAL A 145
VAL A 147
GLN A 151
TRP  A 401 (-4.1A)
TRP  A 401 (-3.9A)
TRP  A 401 (-3.8A)
TRP  A 401 (-4.9A)
TRP  A 401 (-4.7A)
None
TRP  A 401 (-3.5A)
0.61A 3fi0B-2g36A:
32.5
3fi0B-2g36A:
37.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
7 / 9 GLY A   6
HIS A  43
ASP A 136
ILE A 137
VAL A 145
VAL A 147
GLN A 151
TRP  A 401 (-4.1A)
TRP  A 401 (-3.9A)
TRP  A 401 (-3.8A)
TRP  A 401 (-4.9A)
TRP  A 401 (-4.7A)
None
TRP  A 401 (-3.5A)
0.67A 3fi0C-2g36A:
32.8
3fi0C-2g36A:
37.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
7 / 9 GLY A   6
HIS A  43
ASP A 136
ILE A 137
VAL A 145
VAL A 147
GLN A 151
TRP  A 401 (-4.1A)
TRP  A 401 (-3.9A)
TRP  A 401 (-3.8A)
TRP  A 401 (-4.9A)
TRP  A 401 (-4.7A)
None
TRP  A 401 (-3.5A)
0.68A 3fi0D-2g36A:
33.5
3fi0D-2g36A:
37.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
6 / 7 GLY A   6
HIS A  43
ASP A 136
ILE A 137
VAL A 145
GLN A 151
TRP  A 401 (-4.1A)
TRP  A 401 (-3.9A)
TRP  A 401 (-3.8A)
TRP  A 401 (-4.9A)
TRP  A 401 (-4.7A)
TRP  A 401 (-3.5A)
0.59A 3fi0E-2g36A:
31.9
3fi0E-2g36A:
37.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
7 / 9 GLY A   6
HIS A  43
ASP A 136
ILE A 137
VAL A 145
VAL A 147
GLN A 151
TRP  A 401 (-4.1A)
TRP  A 401 (-3.9A)
TRP  A 401 (-3.8A)
TRP  A 401 (-4.9A)
TRP  A 401 (-4.7A)
None
TRP  A 401 (-3.5A)
0.67A 3fi0F-2g36A:
28.2
3fi0F-2g36A:
37.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_G_TRPG1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
6 / 8 GLY A   6
HIS A  43
ASP A 136
ILE A 137
VAL A 145
GLN A 151
TRP  A 401 (-4.1A)
TRP  A 401 (-3.9A)
TRP  A 401 (-3.8A)
TRP  A 401 (-4.9A)
TRP  A 401 (-4.7A)
TRP  A 401 (-3.5A)
0.41A 3fi0G-2g36A:
33.5
3fi0G-2g36A:
37.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_G_TRPG1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
5 / 8 HIS A  43
ILE A 137
VAL A 145
VAL A 147
GLN A 151
TRP  A 401 (-3.9A)
TRP  A 401 (-4.9A)
TRP  A 401 (-4.7A)
None
TRP  A 401 (-3.5A)
0.59A 3fi0G-2g36A:
33.5
3fi0G-2g36A:
37.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_H_TRPH1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
7 / 9 GLY A   6
HIS A  43
ASP A 136
ILE A 137
VAL A 145
VAL A 147
GLN A 151
TRP  A 401 (-4.1A)
TRP  A 401 (-3.9A)
TRP  A 401 (-3.8A)
TRP  A 401 (-4.9A)
TRP  A 401 (-4.7A)
None
TRP  A 401 (-3.5A)
0.58A 3fi0H-2g36A:
33.3
3fi0H-2g36A:
37.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
7 / 8 GLY A   6
HIS A  43
ASP A 136
ILE A 137
VAL A 145
VAL A 147
GLN A 151
TRP  A 401 (-4.1A)
TRP  A 401 (-3.9A)
TRP  A 401 (-3.8A)
TRP  A 401 (-4.9A)
TRP  A 401 (-4.7A)
None
TRP  A 401 (-3.5A)
0.63A 3fi0I-2g36A:
33.2
3fi0I-2g36A:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_J_TRPJ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
7 / 9 GLY A   6
HIS A  43
ASP A 136
ILE A 137
VAL A 145
VAL A 147
GLN A 151
TRP  A 401 (-4.1A)
TRP  A 401 (-3.9A)
TRP  A 401 (-3.8A)
TRP  A 401 (-4.9A)
TRP  A 401 (-4.7A)
None
TRP  A 401 (-3.5A)
0.65A 3fi0J-2g36A:
33.0
3fi0J-2g36A:
37.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_K_TRPK1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
7 / 9 GLY A   6
HIS A  43
ASP A 136
ILE A 137
VAL A 145
VAL A 147
GLN A 151
TRP  A 401 (-4.1A)
TRP  A 401 (-3.9A)
TRP  A 401 (-3.8A)
TRP  A 401 (-4.9A)
TRP  A 401 (-4.7A)
None
TRP  A 401 (-3.5A)
0.64A 3fi0K-2g36A:
32.6
3fi0K-2g36A:
37.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_L_TRPL1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
7 / 9 GLY A   6
HIS A  43
ASP A 136
ILE A 137
VAL A 145
VAL A 147
GLN A 151
TRP  A 401 (-4.1A)
TRP  A 401 (-3.9A)
TRP  A 401 (-3.8A)
TRP  A 401 (-4.9A)
TRP  A 401 (-4.7A)
None
TRP  A 401 (-3.5A)
0.68A 3fi0L-2g36A:
33.2
3fi0L-2g36A:
37.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_M_TRPM1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
7 / 9 GLY A   6
HIS A  43
ASP A 136
ILE A 137
VAL A 145
VAL A 147
GLN A 151
TRP  A 401 (-4.1A)
TRP  A 401 (-3.9A)
TRP  A 401 (-3.8A)
TRP  A 401 (-4.9A)
TRP  A 401 (-4.7A)
None
TRP  A 401 (-3.5A)
0.68A 3fi0M-2g36A:
32.9
3fi0M-2g36A:
37.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_N_TRPN1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
7 / 9 GLY A   6
HIS A  43
ASP A 136
ILE A 137
VAL A 145
VAL A 147
GLN A 151
TRP  A 401 (-4.1A)
TRP  A 401 (-3.9A)
TRP  A 401 (-3.8A)
TRP  A 401 (-4.9A)
TRP  A 401 (-4.7A)
None
TRP  A 401 (-3.5A)
0.68A 3fi0N-2g36A:
33.2
3fi0N-2g36A:
37.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_O_TRPO1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
7 / 9 GLY A   6
HIS A  43
ASP A 136
ILE A 137
VAL A 145
VAL A 147
GLN A 151
TRP  A 401 (-4.1A)
TRP  A 401 (-3.9A)
TRP  A 401 (-3.8A)
TRP  A 401 (-4.9A)
TRP  A 401 (-4.7A)
None
TRP  A 401 (-3.5A)
0.65A 3fi0O-2g36A:
33.3
3fi0O-2g36A:
37.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
5 / 7 GLY A   6
HIS A  43
ASP A 136
ILE A 137
GLN A 151
TRP  A 401 (-4.1A)
TRP  A 401 (-3.9A)
TRP  A 401 (-3.8A)
TRP  A 401 (-4.9A)
TRP  A 401 (-3.5A)
0.54A 3fi0P-2g36A:
32.4
3fi0P-2g36A:
37.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_Q_TRPQ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
6 / 8 GLY A   6
HIS A  43
ASP A 136
ILE A 137
VAL A 145
VAL A 147
TRP  A 401 (-4.1A)
TRP  A 401 (-3.9A)
TRP  A 401 (-3.8A)
TRP  A 401 (-4.9A)
TRP  A 401 (-4.7A)
None
0.49A 3fi0Q-2g36A:
33.1
3fi0Q-2g36A:
37.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_R_TRPR1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
7 / 9 GLY A   6
HIS A  43
ASP A 136
ILE A 137
VAL A 145
VAL A 147
GLN A 151
TRP  A 401 (-4.1A)
TRP  A 401 (-3.9A)
TRP  A 401 (-3.8A)
TRP  A 401 (-4.9A)
TRP  A 401 (-4.7A)
None
TRP  A 401 (-3.5A)
0.59A 3fi0R-2g36A:
31.9
3fi0R-2g36A:
37.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
4 / 7 GLU A 311
VAL A  77
VAL A  84
ALA A 313
None
0.99A 3kp6B-2g36A:
undetectable
3kp6B-2g36A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIM_A_CELA711_1
(LACTOTRANSFERRIN)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
5 / 9 GLU A 143
GLY A 144
PRO A 146
TYR A  37
GLY A   6
None
None
None
None
TRP  A 401 (-4.1A)
1.14A 4fimA-2g36A:
undetectable
4fimA-2g36A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
4 / 7 TRP A 256
ASP A 229
TRP A 239
HIS A 242
None
1.50A 5b1aN-2g36A:
undetectable
5b1aP-2g36A:
undetectable
5b1aN-2g36A:
20.08
5b1aP-2g36A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA901_0
(PROTEIN ARGONAUTE-2)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
4 / 5 LEU A 127
TYR A 129
LEU A 103
TYR A 109
None
TRP  A 401 (-4.5A)
None
None
1.28A 5ki6A-2g36A:
undetectable
5ki6A-2g36A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
3 / 3 THR A 189
PRO A 222
ARG A 224
None
None
SF4  A 400 (-4.4A)
0.81A 5nd7B-2g36A:
undetectable
5nd7B-2g36A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NU7_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 4)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
4 / 8 LEU A 103
ALA A 135
VAL A 100
HIS A  43
None
None
None
TRP  A 401 (-3.9A)
0.98A 5nu7A-2g36A:
undetectable
5nu7A-2g36A:
18.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V0I_A_TRPA402_0
(TRYPTOPHAN--TRNA
LIGASE)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
6 / 9 GLY A   6
HIS A  43
ASP A 136
ILE A 137
VAL A 145
GLN A 151
TRP  A 401 (-4.1A)
TRP  A 401 (-3.9A)
TRP  A 401 (-3.8A)
TRP  A 401 (-4.9A)
TRP  A 401 (-4.7A)
TRP  A 401 (-3.5A)
0.41A 5v0iA-2g36A:
33.3
5v0iA-2g36A:
36.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V0I_B_TRPB402_0
(TRYPTOPHAN--TRNA
LIGASE)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
6 / 9 GLY A   6
HIS A  43
ASP A 136
ILE A 137
VAL A 145
GLN A 151
TRP  A 401 (-4.1A)
TRP  A 401 (-3.9A)
TRP  A 401 (-3.8A)
TRP  A 401 (-4.9A)
TRP  A 401 (-4.7A)
TRP  A 401 (-3.5A)
0.45A 5v0iB-2g36A:
33.7
5v0iB-2g36A:
36.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
4 / 8 THR A 316
PHE A  94
VAL A 312
ILE A 137
None
None
None
TRP  A 401 (-4.9A)
0.97A 5vkqB-2g36A:
undetectable
5vkqC-2g36A:
undetectable
5vkqB-2g36A:
10.98
5vkqC-2g36A:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
5 / 11 MET A 218
LEU A 273
PHE A 245
LEU A 281
ILE A  15
None
1.02A 5z6mA-2g36A:
undetectable
5z6mA-2g36A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_2
(-)
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima)
4 / 5 GLN A 133
THR A 158
THR A 316
LEU A   4
TRP  A 401 (-4.1A)
None
None
None
1.31A 6gbnB-2g36A:
undetectable
6gbnB-2g36A:
20.80