SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2g37'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 2g37 PROLINE
DEHYDROGENASE/DELTA-
1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 LYS A 187
ILE A 231
THR A 226
ARG A 288
ARG A 293
 FAD  A2001 (-2.8A)
None
FAD  A2001 (-3.6A)
None
FAD  A2001 (-3.8A)
 1.15A 1eiiA-2g37A:
undetectable		 1eiiA-2g37A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA6_0
(GRAMICIDIN A)		 2g37 PROLINE
DEHYDROGENASE/DELTA-
1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 ALA A  44
VAL A  36
TRP A 282
 None
 0.94A 1gmkA-2g37A:
undetectable
1gmkB-2g37A:
undetectable		 1gmkA-2g37A:
5.00
1gmkB-2g37A:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC6_0
(GRAMICIDIN A)		 2g37 PROLINE
DEHYDROGENASE/DELTA-
1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 ALA A  44
VAL A  36
TRP A 282
 None
 0.92A 1gmkC-2g37A:
undetectable
1gmkD-2g37A:
undetectable		 1gmkC-2g37A:
5.00
1gmkD-2g37A:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		 2g37 PROLINE
DEHYDROGENASE/DELTA-
1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		5 / 11 ALA A 149
LEU A 150
LEU A 146
LEU A 100
ALA A 114
 None
 1.00A 1h9zA-2g37A:
undetectable		 1h9zA-2g37A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 2g37 PROLINE
DEHYDROGENASE/DELTA-
1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		5 / 11 ALA A 149
LEU A 150
LEU A 146
LEU A 100
ALA A 114
 None
 1.04A 1ha2A-2g37A:
undetectable		 1ha2A-2g37A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2g37 PROLINE
DEHYDROGENASE/DELTA-
1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		5 / 11 LEU A  62
LEU A  60
ALA A  50
ALA A  48
LEU A  41
 None
 1.25A 1iiuA-2g37A:
undetectable		 1iiuA-2g37A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2g37 PROLINE
DEHYDROGENASE/DELTA-
1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 LEU A  62
LEU A  60
ALA A  50
ALA A  48
LEU A  41
 None
 1.17A 1kt5A-2g37A:
undetectable		 1kt5A-2g37A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)		 2g37 PROLINE
DEHYDROGENASE/DELTA-
1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 PHE A 224
LEU A 216
MET A 242
 None
 0.82A 1mx1D-2g37A:
2.1		 1mx1D-2g37A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2003_1
(SERUM ALBUMIN)		 2g37 PROLINE
DEHYDROGENASE/DELTA-
1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		5 / 10 LEU A 150
ARG A 117
LEU A 146
LEU A 100
ALA A 114
 None
 1.15A 2bxeB-2g37A:
undetectable		 2bxeB-2g37A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		 2g37 PROLINE
DEHYDROGENASE/DELTA-
1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		5 / 11 LEU A 162
LEU A 183
ARG A 184
GLN A 252
ILE A 160
 None
None
FAD  A2001 (-3.9A)
FAD  A2001 (-4.7A)
None
 1.24A 2q6hA-2g37A:
undetectable		 2q6hA-2g37A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		 2g37 PROLINE
DEHYDROGENASE/DELTA-
1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		5 / 11 LEU A 162
LEU A 183
ARG A 184
GLN A 252
ILE A 160
 None
None
FAD  A2001 (-3.9A)
FAD  A2001 (-4.7A)
None
 1.24A 2qeiA-2g37A:
undetectable		 2qeiA-2g37A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_1
(AAC(6')-IB)		 2g37 PROLINE
DEHYDROGENASE/DELTA-
1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 TYR A 255
LEU A  51
GLU A  54
VAL A  56
GLN A 262
 None
 1.32A 2vqyA-2g37A:
undetectable		 2vqyA-2g37A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1100_1
(SERUM ALBUMIN)		 2g37 PROLINE
DEHYDROGENASE/DELTA-
1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		4 / 4 LEU A 132
ARG A 117
LEU A 120
ALA A 149
 None
 1.19A 3b9mA-2g37A:
undetectable		 3b9mA-2g37A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 2g37 PROLINE
DEHYDROGENASE/DELTA-
1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 ILE A  59
PHE A 129
VAL A 161
GLY A 159
 None
MPD  A 373 (-3.6A)
FAD  A2001 (-4.3A)
None
 0.82A 4ac9C-2g37A:
2.6		 4ac9C-2g37A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 2g37 PROLINE
DEHYDROGENASE/DELTA-
1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 PHE A 129
VAL A 130
ILE A  96
ALA A  48
 MPD  A 373 (-3.6A)
None
None
None
 1.02A 4eyzA-2g37A:
undetectable		 4eyzA-2g37A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2g37 PROLINE
DEHYDROGENASE/DELTA-
1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 VAL A 119
LEU A 116
LEU A 103
ASP A  61
 None
 0.90A 4lzrA-2g37A:
undetectable		 4lzrA-2g37A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA902_0
(PROTEIN ARGONAUTE-2)		 2g37 PROLINE
DEHYDROGENASE/DELTA-
1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		4 / 5 LYS A 213
LEU A 235
GLU A 234
TYR A 238
 None
 1.49A 4olbA-2g37A:
undetectable		 4olbA-2g37A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 2g37 PROLINE
DEHYDROGENASE/DELTA-
1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 LEU A  45
LEU A  60
ARG A 263
 None
 0.41A 5hnzB-2g37A:
2.8		 5hnzB-2g37A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2g37 PROLINE
DEHYDROGENASE/DELTA-
1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		4 / 5 LYS A 213
LEU A 235
GLU A 234
TYR A 238
 None
 1.47A 5js1A-2g37A:
2.2		 5js1A-2g37A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2g37 PROLINE
DEHYDROGENASE/DELTA-
1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 LEU A 116
ALA A 112
LEU A 150
 None
 0.42A 5uunB-2g37A:
undetectable		 5uunB-2g37A:
25.58