SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2g3n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_1
(PROTEIN (PROTEASE))		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A 115
ILE A 102
GLY A  66
ILE A  65
PRO A 528
 None
 0.74A 1c6zA-2g3nA:
undetectable		 1c6zA-2g3nA:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 ALA A 519
ILE A 446
ARG A 531
LEU A 472
LEU A 512
 None
 1.37A 1eiiA-2g3nA:
undetectable		 1eiiA-2g3nA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		4 / 8 TYR A 477
TYR A 467
LEU A 424
LEU A 472
 None
 1.09A 1i7zA-2g3nA:
undetectable		 1i7zA-2g3nA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		4 / 6 VAL A 289
ILE A 254
TRP A 302
LEU A 319
 None
 1.25A 1j96A-2g3nA:
3.0		 1j96A-2g3nA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		3 / 3 PHE A 229
LEU A 211
LEU A 246
 None
 0.68A 1mx1E-2g3nA:
undetectable		 1mx1E-2g3nA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_2
(PROTEASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		6 / 11 ARG A 154
GLY A 115
ILE A 102
GLY A  66
ILE A  65
PRO A 528
 None
 1.22A 1n49B-2g3nA:
undetectable		 1n49B-2g3nA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 ILE A 608
ILE A 631
ILE A 638
LEU A 692
VAL A 657
 None
 0.87A 1oipA-2g3nA:
2.0		 1oipA-2g3nA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 LEU A 556
GLY A 583
ILE A 600
LEU A 533
THR A 571
 None
 1.10A 1p91B-2g3nA:
undetectable		 1p91B-2g3nA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		4 / 6 TYR A 186
GLU A 489
PRO A 490
VAL A 206
 None
 1.13A 1q13A-2g3nA:
4.7		 1q13A-2g3nA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		3 / 3 ASP A 416
LYS A 481
ARG A 183
 BOG  A2000 (-3.0A)
None
None
 0.70A 1ra8A-2g3nA:
undetectable		 1ra8A-2g3nA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 8 ILE A 102
GLY A  68
GLY A  66
ILE A  65
PRO A 528
 None
 1.18A 1sguA-2g3nA:
undetectable		 1sguA-2g3nA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A 115
ILE A 102
GLY A  66
ILE A  65
PRO A 528
 None
 0.81A 1sh9B-2g3nA:
undetectable		 1sh9B-2g3nA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		3 / 3 ASP A 157
GLU A 536
TYR A 544
 None
 0.76A 1wsvA-2g3nA:
undetectable		 1wsvA-2g3nA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		4 / 8 VAL A 192
ASP A 197
TYR A 186
LEU A 211
 None
 1.01A 1z2bB-2g3nA:
undetectable		 1z2bB-2g3nA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_2
(HIV-1 PROTEASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		6 / 11 ARG A 154
GLY A 115
ILE A 102
GLY A  66
ILE A  65
PRO A 528
 None
 1.32A 2aquB-2g3nA:
undetectable		 2aquB-2g3nA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_3
(POL POLYPROTEIN)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A 115
ILE A 102
GLY A  66
ILE A  65
PRO A 528
 None
 0.76A 2avvE-2g3nA:
undetectable		 2avvE-2g3nA:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_1
(PROTEASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A 115
ILE A 102
GLY A  66
ILE A  65
PRO A 528
 None
 0.70A 2nmzA-2g3nA:
undetectable		 2nmzA-2g3nA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_3
(PROTEASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A 115
ILE A 102
GLY A  66
ILE A  65
PRO A 528
 None
 0.86A 2nnkB-2g3nA:
undetectable		 2nnkB-2g3nA:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_1
(PROTEASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 11 GLY A 115
ILE A 102
GLY A  66
ILE A  65
PRO A 528
 None
 0.77A 2nnpA-2g3nA:
undetectable		 2nnpA-2g3nA:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A 115
ILE A 102
GLY A  66
ILE A  65
PRO A 528
 None
 0.75A 2q63A-2g3nA:
undetectable		 2q63A-2g3nA:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A 115
ILE A 102
GLY A  66
ILE A  65
PRO A 528
 None
 0.75A 2q63B-2g3nA:
undetectable		 2q63B-2g3nA:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_1
(PROTEASE RETROPEPSIN)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A 115
ILE A 102
GLY A  66
ILE A  65
PRO A 528
 None
 0.74A 2q64A-2g3nA:
undetectable		 2q64A-2g3nA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_A_ADNA1_1
(YTAA PROTEIN)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		4 / 7 ILE A 607
ILE A 660
LEU A 692
ILE A 651
 None
 0.89A 2q83A-2g3nA:
undetectable		 2q83A-2g3nA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A 115
ILE A 102
GLY A  66
ILE A  65
PRO A 528
 None
 0.79A 2qakA-2g3nA:
undetectable		 2qakA-2g3nA:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA426_0
(FERROCHELATASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		4 / 4 LEU A 572
PRO A 573
LEU A 557
ARG A 568
 None
 1.41A 2qd2A-2g3nA:
undetectable		 2qd2A-2g3nA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		6 / 12 ASP A  87
ASP A 212
ILE A 213
ASP A 416
PHE A 449
HIS A 480
 BOG  A2000 (-2.7A)
None
None
BOG  A2000 (-3.0A)
None
None
 1.37A 2qmjA-2g3nA:
40.7		 2qmjA-2g3nA:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		10 / 12 ASP A  87
ASP A 212
ILE A 213
ILE A 249
TRP A 284
ASP A 320
ARG A 400
ASP A 416
PHE A 449
HIS A 480
 BOG  A2000 (-2.7A)
None
None
None
None
None
BOG  A2000 (-3.1A)
BOG  A2000 (-3.0A)
None
None
 0.46A 2qmjA-2g3nA:
40.7		 2qmjA-2g3nA:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 ASP A 416
ASP A  87
ARG A 400
ASP A 320
HIS A 252
 BOG  A2000 (-3.0A)
BOG  A2000 (-2.7A)
BOG  A2000 (-3.1A)
None
None
 1.34A 2qmjA-2g3nA:
40.7		 2qmjA-2g3nA:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 ASP A 445
ILE A 249
ILE A 213
ASP A 416
ALA A  88
 None
None
None
BOG  A2000 (-3.0A)
None
 1.33A 2qmjA-2g3nA:
40.7		 2qmjA-2g3nA:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_2
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 6 TYR A 184
TRP A 318
MET A 321
TRP A 413
THR A 418
 BOG  A2000 (-4.5A)
None
BOG  A2000 ( 4.0A)
None
None
 0.34A 2qmjA-2g3nA:
40.7		 2qmjA-2g3nA:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_2
(PROTEASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 11 GLY A 115
ILE A 102
GLY A  66
ILE A  65
PRO A 528
 None
 0.83A 2r5qB-2g3nA:
undetectable		 2r5qB-2g3nA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_2
(PROTEASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 10 GLY A 115
ILE A 102
GLY A  66
ILE A  65
PRO A 528
 None
 0.83A 2r5qD-2g3nA:
undetectable		 2r5qD-2g3nA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_A_BEZA1222_0
(PEROXIREDOXIN 6)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		4 / 7 THR A 418
PRO A 419
SER A 420
GLU A 456
 None
 1.05A 2v2gA-2g3nA:
undetectable
2v2gB-2g3nA:
undetectable		 2v2gA-2g3nA:
17.41
2v2gB-2g3nA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_B_BEZB1220_0
(PEROXIREDOXIN 6)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		4 / 7 THR A 418
PRO A 419
SER A 420
GLU A 456
 None
 1.05A 2v2gA-2g3nA:
undetectable
2v2gB-2g3nA:
undetectable		 2v2gA-2g3nA:
17.41
2v2gB-2g3nA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_C_BEZC1222_0
(PEROXIREDOXIN 6)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		4 / 7 THR A 418
PRO A 419
SER A 420
GLU A 456
 None
 1.05A 2v2gC-2g3nA:
undetectable
2v2gD-2g3nA:
undetectable		 2v2gC-2g3nA:
17.41
2v2gD-2g3nA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_D_BEZD1221_0
(PEROXIREDOXIN 6)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		4 / 7 THR A 418
PRO A 419
SER A 420
GLU A 456
 None
 1.04A 2v2gC-2g3nA:
undetectable
2v2gD-2g3nA:
undetectable		 2v2gC-2g3nA:
17.41
2v2gD-2g3nA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 10 TYR A 467
PHE A 474
TYR A  91
LEU A 424
LEU A 470
 None
 1.41A 2w98A-2g3nA:
undetectable		 2w98A-2g3nA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		3 / 3 SER A 437
HIS A  63
ASP A 540
 None
 0.78A 2wa2B-2g3nA:
undetectable		 2wa2B-2g3nA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		6 / 12 ASP A  87
ASP A 212
ASP A 320
ASP A 416
PHE A 449
HIS A 480
 BOG  A2000 (-2.7A)
None
None
BOG  A2000 (-3.0A)
None
None
 0.44A 2x2iA-2g3nA:
31.4		 2x2iA-2g3nA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		4 / 6 TRP A 318
MET A 321
ARG A 400
TRP A 413
 None
BOG  A2000 ( 4.0A)
BOG  A2000 (-3.1A)
None
 0.48A 2x2iA-2g3nA:
31.4		 2x2iA-2g3nA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		7 / 12 ASP A  87
ASP A 212
ASP A 320
MET A 321
ASP A 416
PHE A 449
HIS A 480
 BOG  A2000 (-2.7A)
None
None
BOG  A2000 ( 4.0A)
BOG  A2000 (-3.0A)
None
None
 0.47A 2x2iB-2g3nA:
31.4		 2x2iB-2g3nA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		7 / 12 ASP A  87
ASP A 212
ASP A 320
MET A 321
ASP A 416
PHE A 449
HIS A 480
 BOG  A2000 (-2.7A)
None
None
BOG  A2000 ( 4.0A)
BOG  A2000 (-3.0A)
None
None
 0.40A 2x2iC-2g3nA:
31.4		 2x2iC-2g3nA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		7 / 12 ASP A  87
ASP A 212
ASP A 320
MET A 321
ASP A 416
PHE A 449
HIS A 480
 BOG  A2000 (-2.7A)
None
None
BOG  A2000 ( 4.0A)
BOG  A2000 (-3.0A)
None
None
 0.40A 2x2iD-2g3nA:
31.3		 2x2iD-2g3nA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 LEU A 610
ILE A 682
LEU A 649
VAL A 617
ILE A 607
 None
 0.94A 3adxB-2g3nA:
undetectable		 3adxB-2g3nA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_1
(HIV-1 PROTEASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A 115
ILE A 102
GLY A  66
ILE A  65
PRO A 528
 None
 0.81A 3d1xA-2g3nA:
undetectable		 3d1xA-2g3nA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 ALA A 410
LEU A 319
ILE A 306
LEU A 310
ARG A 392
 None
 1.10A 3datA-2g3nA:
undetectable		 3datA-2g3nA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_2
(PROTEASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A 115
ILE A 102
GLY A  66
ILE A  65
PRO A 528
 None
 0.73A 3el1B-2g3nA:
undetectable		 3el1B-2g3nA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_1
(PROTEASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A 115
ILE A 102
GLY A  66
ILE A  65
PRO A 528
 None
 0.81A 3el4A-2g3nA:
undetectable		 3el4A-2g3nA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 10 TYR A 162
ILE A 102
GLY A 405
VAL A 442
LEU A 159
 None
 1.40A 3elzB-2g3nA:
undetectable		 3elzB-2g3nA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 PHE A 210
ILE A 247
PHE A 170
VAL A 439
LEU A 434
 None
 1.33A 3em0B-2g3nA:
undetectable		 3em0B-2g3nA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		4 / 8 ILE A 608
PRO A 609
VAL A 552
GLY A 553
 None
 0.77A 3em0B-2g3nA:
undetectable		 3em0B-2g3nA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 10 ALA A 410
LEU A 319
ILE A 306
LEU A 310
PHE A 387
 None
 1.19A 3fl9A-2g3nA:
undetectable		 3fl9A-2g3nA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 9 ALA A 410
LEU A 319
ILE A 306
LEU A 310
PHE A 387
 None
 1.21A 3fl9D-2g3nA:
undetectable		 3fl9D-2g3nA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 10 ALA A 410
LEU A 319
ILE A 306
LEU A 310
PHE A 387
 None
 1.15A 3fl9F-2g3nA:
undetectable		 3fl9F-2g3nA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 ARG A 255
GLY A 281
THR A 287
PHE A 353
ILE A 273
 None
 1.35A 3iv6C-2g3nA:
undetectable		 3iv6C-2g3nA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		4 / 8 ASP A 548
VAL A 570
LEU A 572
PRO A 573
 None
 0.96A 3jq7C-2g3nA:
undetectable		 3jq7C-2g3nA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_3
(HIV-1 PROTEASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A 115
ILE A 102
GLY A  66
ILE A  65
PRO A 528
 None
 0.85A 3k4vB-2g3nA:
undetectable		 3k4vB-2g3nA:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		4 / 8 GLY A 447
ILE A 181
PHE A 396
PHE A 476
 None
 0.99A 3ko0K-2g3nA:
undetectable
3ko0S-2g3nA:
undetectable		 3ko0K-2g3nA:
11.28
3ko0S-2g3nA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		4 / 7 GLY A 448
PHE A 411
PHE A 396
PHE A 210
 None
 1.08A 3ko0L-2g3nA:
undetectable
3ko0N-2g3nA:
undetectable		 3ko0L-2g3nA:
11.28
3ko0N-2g3nA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		4 / 7 PHE A 210
GLY A 448
PHE A 411
PHE A 396
 None
 1.12A 3ko0K-2g3nA:
undetectable
3ko0S-2g3nA:
undetectable		 3ko0K-2g3nA:
11.28
3ko0S-2g3nA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		4 / 7 PHE A 210
GLY A 447
PHE A 411
PHE A 396
 None
 1.09A 3ko0R-2g3nA:
undetectable
3ko0T-2g3nA:
undetectable		 3ko0R-2g3nA:
11.28
3ko0T-2g3nA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		4 / 7 PHE A 210
GLY A 448
PHE A 411
PHE A 396
 None
 0.94A 3ko0R-2g3nA:
undetectable
3ko0T-2g3nA:
undetectable		 3ko0R-2g3nA:
11.28
3ko0T-2g3nA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4W_A_MIGA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		11 / 12 TYR A 184
ASP A 212
ILE A 213
ILE A 249
TRP A 284
TRP A 318
ASP A 320
TRP A 413
ASP A 416
PHE A 449
HIS A 480
 BOG  A2000 (-4.5A)
None
None
None
None
None
None
None
BOG  A2000 (-3.0A)
None
None
 0.60A 3l4wA-2g3nA:
37.8		 3l4wA-2g3nA:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4W_A_MIGA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		11 / 12 TYR A 184
ASP A 212
ILE A 213
ILE A 249
TRP A 318
ASP A 320
MET A 321
TRP A 413
ASP A 416
PHE A 449
HIS A 480
 BOG  A2000 (-4.5A)
None
None
None
None
None
BOG  A2000 ( 4.0A)
None
BOG  A2000 (-3.0A)
None
None
 0.32A 3l4wA-2g3nA:
37.8		 3l4wA-2g3nA:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_3
(PROTEASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		6 / 12 ARG A 154
GLY A 115
ILE A 102
GLY A  66
ILE A  65
PRO A 528
 None
 1.22A 3ndtB-2g3nA:
undetectable		 3ndtB-2g3nA:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_D_ROCD100_1
(PROTEASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A 115
ILE A 102
GLY A  66
ILE A  65
PRO A 528
 None
 0.69A 3ndtC-2g3nA:
undetectable		 3ndtC-2g3nA:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		4 / 8 ASP A 487
PRO A 188
TYR A 187
GLU A 489
 None
 1.14A 3oyaA-2g3nA:
2.0		 3oyaA-2g3nA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		3 / 3 ASP A 445
GLU A  69
SER A 185
 None
 0.78A 3p2kA-2g3nA:
undetectable		 3p2kA-2g3nA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_A_ACRA701_1
(ALPHA-GLUCOSIDASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		11 / 12 ASP A  87
ASP A 212
ILE A 213
ILE A 249
TRP A 284
ASP A 320
ARG A 400
TRP A 413
ASP A 416
PHE A 449
HIS A 480
 BOG  A2000 (-2.7A)
None
None
None
None
None
BOG  A2000 (-3.1A)
None
BOG  A2000 (-3.0A)
None
None
 0.51A 3phaA-2g3nA:
42.7		 3phaA-2g3nA:
27.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		10 / 12 ASP A  87
ASP A 212
ILE A 213
ILE A 249
TRP A 284
ASP A 320
ARG A 400
ASP A 416
PHE A 449
HIS A 480
 BOG  A2000 (-2.7A)
None
None
None
None
None
BOG  A2000 (-3.1A)
BOG  A2000 (-3.0A)
None
None
 0.54A 3phaB-2g3nA:
42.6		 3phaB-2g3nA:
27.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_C_ACRC701_1
(ALPHA-GLUCOSIDASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		10 / 12 ASP A  87
ASP A 212
ILE A 213
TRP A 284
ASP A 320
ARG A 400
TRP A 413
ASP A 416
PHE A 449
HIS A 480
 BOG  A2000 (-2.7A)
None
None
None
None
BOG  A2000 (-3.1A)
None
BOG  A2000 (-3.0A)
None
None
 0.52A 3phaC-2g3nA:
41.5		 3phaC-2g3nA:
27.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_C_ACRC701_1
(ALPHA-GLUCOSIDASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		6 / 12 ASP A  87
ASP A 212
ILE A 249
ARG A 400
ASP A 416
PHE A 449
 BOG  A2000 (-2.7A)
None
None
BOG  A2000 (-3.1A)
BOG  A2000 (-3.0A)
None
 1.38A 3phaC-2g3nA:
41.5		 3phaC-2g3nA:
27.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_D_ACRD701_1
(ALPHA-GLUCOSIDASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		10 / 12 ASP A  87
ASP A 212
ILE A 213
TRP A 284
ASP A 320
MET A 321
ARG A 400
ASP A 416
PHE A 449
HIS A 480
 BOG  A2000 (-2.7A)
None
None
None
None
BOG  A2000 ( 4.0A)
BOG  A2000 (-3.1A)
BOG  A2000 (-3.0A)
None
None
 0.51A 3phaD-2g3nA:
41.7		 3phaD-2g3nA:
27.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_D_ACRD701_1
(ALPHA-GLUCOSIDASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		6 / 12 ASP A  87
ASP A 212
ILE A 249
MET A 321
ASP A 416
PHE A 449
 BOG  A2000 (-2.7A)
None
None
BOG  A2000 ( 4.0A)
BOG  A2000 (-3.0A)
None
 1.40A 3phaD-2g3nA:
41.7		 3phaD-2g3nA:
27.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_D_ACRD701_1
(ALPHA-GLUCOSIDASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 ASP A 416
ASP A  87
ARG A 400
ASP A 320
HIS A 252
 BOG  A2000 (-3.0A)
BOG  A2000 (-2.7A)
BOG  A2000 (-3.1A)
None
None
 1.29A 3phaD-2g3nA:
41.7		 3phaD-2g3nA:
27.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_A_ACRA664_1
(ALPHA-GLUCOSIDASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		10 / 12 ASP A 212
ILE A 213
ILE A 249
TRP A 284
MET A 321
ARG A 400
TRP A 413
ASP A 416
PHE A 449
HIS A 480
 None
None
None
None
BOG  A2000 ( 4.0A)
BOG  A2000 (-3.1A)
None
BOG  A2000 (-3.0A)
None
None
 0.51A 3pocA-2g3nA:
41.7		 3pocA-2g3nA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_A_ACRA664_1
(ALPHA-GLUCOSIDASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		8 / 12 ASP A 212
ILE A 213
ILE A 249
TRP A 284
TRP A 318
TRP A 413
PHE A 449
HIS A 480
 None
 0.98A 3pocA-2g3nA:
41.7		 3pocA-2g3nA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_A_ACRA664_1
(ALPHA-GLUCOSIDASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		7 / 12 ASP A 212
ILE A 249
MET A 321
ARG A 400
ASP A 416
PHE A 449
HIS A 480
 None
None
BOG  A2000 ( 4.0A)
BOG  A2000 (-3.1A)
BOG  A2000 (-3.0A)
None
None
 1.38A 3pocA-2g3nA:
41.7		 3pocA-2g3nA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_B_ACRB664_1
(ALPHA-GLUCOSIDASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		10 / 12 ASP A 212
ILE A 213
ILE A 249
TRP A 284
MET A 321
ARG A 400
TRP A 413
ASP A 416
PHE A 449
HIS A 480
 None
None
None
None
BOG  A2000 ( 4.0A)
BOG  A2000 (-3.1A)
None
BOG  A2000 (-3.0A)
None
None
 0.55A 3pocB-2g3nA:
42.5		 3pocB-2g3nA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_B_ACRB664_1
(ALPHA-GLUCOSIDASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		8 / 12 ASP A 212
ILE A 213
ILE A 249
TRP A 284
TRP A 318
TRP A 413
PHE A 449
HIS A 480
 None
 1.02A 3pocB-2g3nA:
42.5		 3pocB-2g3nA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_B_ACRB664_1
(ALPHA-GLUCOSIDASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		7 / 12 ASP A 212
ILE A 249
MET A 321
ARG A 400
ASP A 416
PHE A 449
HIS A 480
 None
None
BOG  A2000 ( 4.0A)
BOG  A2000 (-3.1A)
BOG  A2000 (-3.0A)
None
None
 1.40A 3pocB-2g3nA:
42.5		 3pocB-2g3nA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 PHE A 411
PHE A 177
ILE A 530
GLY A 443
PHE A 476
 None
 1.20A 3ps9A-2g3nA:
2.5		 3ps9A-2g3nA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_1
(PROTEASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A 115
ILE A 102
GLY A  66
ILE A  65
PRO A 528
 None
 0.76A 3tkgC-2g3nA:
undetectable		 3tkgC-2g3nA:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_1
(PROTEASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A 115
ILE A 102
GLY A  66
ILE A  65
PRO A 528
 None
 0.78A 3tl9A-2g3nA:
undetectable		 3tl9A-2g3nA:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_A_ACRA1_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		10 / 12 ASP A  87
ASP A 212
ILE A 249
TRP A 284
ASP A 320
MET A 321
ARG A 400
ASP A 416
PHE A 449
HIS A 480
 BOG  A2000 (-2.7A)
None
None
None
None
BOG  A2000 ( 4.0A)
BOG  A2000 (-3.1A)
BOG  A2000 (-3.0A)
None
None
 0.56A 3topA-2g3nA:
34.9		 3topA-2g3nA:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_A_ACRA1_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 ASP A  87
TRP A 284
MET A 321
ASP A 416
PHE A 449
 BOG  A2000 (-2.7A)
None
BOG  A2000 ( 4.0A)
BOG  A2000 (-3.0A)
None
 1.46A 3topA-2g3nA:
34.9		 3topA-2g3nA:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_A_ACRA1_2
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		4 / 5 ILE A 213
TRP A 318
TRP A 413
THR A 418
 None
 0.28A 3topA-2g3nA:
34.9		 3topA-2g3nA:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_B_ACRB1_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		10 / 12 ASP A  87
ASP A 212
ILE A 249
TRP A 284
ASP A 320
MET A 321
ARG A 400
ASP A 416
PHE A 449
HIS A 480
 BOG  A2000 (-2.7A)
None
None
None
None
BOG  A2000 ( 4.0A)
BOG  A2000 (-3.1A)
BOG  A2000 (-3.0A)
None
None
 0.56A 3topB-2g3nA:
34.9		 3topB-2g3nA:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_B_ACRB1_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 ASP A 416
ASP A  87
ARG A 400
ASP A 320
HIS A 252
 BOG  A2000 (-3.0A)
BOG  A2000 (-2.7A)
BOG  A2000 (-3.1A)
None
None
 1.37A 3topB-2g3nA:
34.9		 3topB-2g3nA:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		3 / 3 TYR A 514
GLU A 611
TYR A 509
 None
 1.02A 3ug8A-2g3nA:
undetectable		 3ug8A-2g3nA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W37_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		6 / 12 ALA A  88
ILE A 249
TRP A 318
ASP A 320
MET A 321
ARG A 400
 None
None
None
None
BOG  A2000 ( 4.0A)
BOG  A2000 (-3.1A)
 1.13A 3w37A-2g3nA:
41.0		 3w37A-2g3nA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W37_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 ALA A  90
ASP A 212
ILE A 249
PHE A 449
HIS A 480
 None
 0.82A 3w37A-2g3nA:
41.0		 3w37A-2g3nA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W37_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		10 / 12 ASP A  87
ASP A 212
ILE A 249
TRP A 318
ASP A 320
MET A 321
ARG A 400
ASP A 416
PHE A 449
HIS A 480
 BOG  A2000 (-2.7A)
None
None
None
None
BOG  A2000 ( 4.0A)
BOG  A2000 (-3.1A)
BOG  A2000 (-3.0A)
None
None
 0.26A 3w37A-2g3nA:
41.0		 3w37A-2g3nA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W37_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 ASP A 416
ASP A  87
ARG A 400
ASP A 320
HIS A 252
 BOG  A2000 (-3.0A)
BOG  A2000 (-2.7A)
BOG  A2000 (-3.1A)
None
None
 1.33A 3w37A-2g3nA:
41.0		 3w37A-2g3nA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 ALA A  88
ILE A 249
TRP A 318
ASP A 320
ARG A 400
 None
None
None
None
BOG  A2000 (-3.1A)
 1.17A 3welA-2g3nA:
40.9		 3welA-2g3nA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 ALA A  90
ASP A 212
ILE A 249
PHE A 449
HIS A 480
 None
 0.85A 3welA-2g3nA:
40.9		 3welA-2g3nA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 ASP A  87
ASP A 212
ILE A 213
ASP A 416
PHE A 449
 BOG  A2000 (-2.7A)
None
None
BOG  A2000 (-3.0A)
None
 1.49A 3welA-2g3nA:
40.9		 3welA-2g3nA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		9 / 12 ASP A  87
ASP A 212
ILE A 249
TRP A 318
ASP A 320
ARG A 400
ASP A 416
PHE A 449
HIS A 480
 BOG  A2000 (-2.7A)
None
None
None
None
BOG  A2000 (-3.1A)
BOG  A2000 (-3.0A)
None
None
 0.29A 3welA-2g3nA:
40.9		 3welA-2g3nA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 ASP A 416
ASP A  87
ARG A 400
ASP A 320
HIS A 252
 BOG  A2000 (-3.0A)
BOG  A2000 (-2.7A)
BOG  A2000 (-3.1A)
None
None
 1.34A 3welA-2g3nA:
40.9		 3welA-2g3nA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		4 / 6 ILE A 213
TRP A 284
MET A 321
TRP A 413
 None
None
BOG  A2000 ( 4.0A)
None
 0.48A 3welA-2g3nA:
40.9		 3welA-2g3nA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEM_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		6 / 12 ALA A  88
ASP A 212
ILE A 213
ASP A 320
MET A 321
ARG A 400
 None
None
None
None
BOG  A2000 ( 4.0A)
BOG  A2000 (-3.1A)
 1.18A 3wemA-2g3nA:
40.8		 3wemA-2g3nA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEM_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		6 / 12 ASP A  87
ALA A  90
ASP A 212
ILE A 213
PHE A 449
HIS A 480
 BOG  A2000 (-2.7A)
None
None
None
None
None
 0.96A 3wemA-2g3nA:
40.8		 3wemA-2g3nA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEM_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		9 / 12 ASP A  87
ASP A 212
ILE A 213
ASP A 320
MET A 321
ARG A 400
ASP A 416
PHE A 449
HIS A 480
 BOG  A2000 (-2.7A)
None
None
None
BOG  A2000 ( 4.0A)
BOG  A2000 (-3.1A)
BOG  A2000 (-3.0A)
None
None
 0.30A 3wemA-2g3nA:
40.8		 3wemA-2g3nA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEM_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		7 / 12 ASP A  87
ASP A 212
ILE A 249
MET A 321
ASP A 416
PHE A 449
HIS A 480
 BOG  A2000 (-2.7A)
None
None
BOG  A2000 ( 4.0A)
BOG  A2000 (-3.0A)
None
None
 1.44A 3wemA-2g3nA:
40.8		 3wemA-2g3nA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEM_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 ASP A 416
ALA A  88
ASP A 251
ILE A 249
ASP A  87
 BOG  A2000 (-3.0A)
None
None
None
BOG  A2000 (-2.7A)
 1.26A 3wemA-2g3nA:
40.8		 3wemA-2g3nA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEN_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		7 / 12 ALA A  88
ASP A 212
ILE A 213
TRP A 318
ASP A 320
MET A 321
ARG A 400
 None
None
None
None
None
BOG  A2000 ( 4.0A)
BOG  A2000 (-3.1A)
 1.16A 3wenA-2g3nA:
40.7		 3wenA-2g3nA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEN_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		6 / 12 ASP A  87
ALA A  90
ASP A 212
ILE A 213
PHE A 449
HIS A 480
 BOG  A2000 (-2.7A)
None
None
None
None
None
 0.96A 3wenA-2g3nA:
40.7		 3wenA-2g3nA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEN_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		10 / 12 ASP A  87
ASP A 212
ILE A 213
TRP A 318
ASP A 320
MET A 321
ARG A 400
ASP A 416
PHE A 449
HIS A 480
 BOG  A2000 (-2.7A)
None
None
None
None
BOG  A2000 ( 4.0A)
BOG  A2000 (-3.1A)
BOG  A2000 (-3.0A)
None
None
 0.31A 3wenA-2g3nA:
40.7		 3wenA-2g3nA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEN_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		7 / 12 ASP A  87
ASP A 212
ILE A 249
MET A 321
ASP A 416
PHE A 449
HIS A 480
 BOG  A2000 (-2.7A)
None
None
BOG  A2000 ( 4.0A)
BOG  A2000 (-3.0A)
None
None
 1.45A 3wenA-2g3nA:
40.7		 3wenA-2g3nA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEN_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 ASP A 416
ASP A  87
ARG A 400
ASP A 320
HIS A 252
 BOG  A2000 (-3.0A)
BOG  A2000 (-2.7A)
BOG  A2000 (-3.1A)
None
None
 1.36A 3wenA-2g3nA:
40.7		 3wenA-2g3nA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		6 / 12 ALA A  88
ASP A 212
ILE A 213
TRP A 318
ASP A 320
ARG A 400
 None
None
None
None
None
BOG  A2000 (-3.1A)
 1.12A 3weoA-2g3nA:
37.4		 3weoA-2g3nA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 ALA A  90
ASP A 212
ILE A 213
PHE A 449
HIS A 480
 None
 0.66A 3weoA-2g3nA:
37.4		 3weoA-2g3nA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		9 / 12 ASP A  87
ASP A 212
ILE A 213
TRP A 318
ASP A 320
ARG A 400
ASP A 416
PHE A 449
HIS A 480
 BOG  A2000 (-2.7A)
None
None
None
None
BOG  A2000 (-3.1A)
BOG  A2000 (-3.0A)
None
None
 0.29A 3weoA-2g3nA:
37.4		 3weoA-2g3nA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		6 / 12 ASP A  87
ASP A 212
ILE A 249
ASP A 416
PHE A 449
HIS A 480
 BOG  A2000 (-2.7A)
None
None
BOG  A2000 (-3.0A)
None
None
 1.44A 3weoA-2g3nA:
37.4		 3weoA-2g3nA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 ASP A 416
ASP A  87
ARG A 400
ASP A 320
HIS A 252
 BOG  A2000 (-3.0A)
BOG  A2000 (-2.7A)
BOG  A2000 (-3.1A)
None
None
 1.32A 3weoA-2g3nA:
37.4		 3weoA-2g3nA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		4 / 6 ILE A 249
TRP A 284
MET A 321
TRP A 413
 None
None
BOG  A2000 ( 4.0A)
None
 0.42A 3weoA-2g3nA:
37.4		 3weoA-2g3nA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		4 / 5 THR A 139
ILE A 140
LYS A  51
PHE A 147
 None
 1.29A 4ac9C-2g3nA:
undetectable		 4ac9C-2g3nA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_1
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 ASP A 212
ILE A 213
ASP A 416
PHE A 449
HIS A 480
 None
None
BOG  A2000 (-3.0A)
None
None
 1.35A 4b9zA-2g3nA:
39.9		 4b9zA-2g3nA:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_1
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		7 / 12 ASP A 212
ILE A 249
ASP A 320
ARG A 400
ASP A 416
PHE A 449
HIS A 480
 None
None
None
BOG  A2000 (-3.1A)
BOG  A2000 (-3.0A)
None
None
 0.25A 4b9zA-2g3nA:
39.9		 4b9zA-2g3nA:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_B_ACTB1114_0
(BLR5658 PROTEIN)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		3 / 3 TRP A 302
TRP A 301
THR A 298
 None
 1.32A 4bboB-2g3nA:
undetectable		 4bboB-2g3nA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_1
(ASPARTYL PROTEASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 LEU A   4
VAL A 145
ILE A 140
VAL A  15
ILE A  17
 None
 0.83A 4dqbA-2g3nA:
undetectable		 4dqbA-2g3nA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		4 / 6 ASN A 119
ARG A 362
TYR A 378
LEU A 377
 None
 1.39A 4f8yA-2g3nA:
undetectable
4f8yB-2g3nA:
undetectable		 4f8yA-2g3nA:
16.02
4f8yB-2g3nA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		4 / 7 ARG A 362
TYR A 378
LEU A 377
ASN A 119
 None
 1.40A 4f8yC-2g3nA:
undetectable
4f8yD-2g3nA:
undetectable		 4f8yC-2g3nA:
16.02
4f8yD-2g3nA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 ILE A 395
ALA A 410
ALA A 382
PHE A 384
LYS A 385
 None
 0.93A 4kjjA-2g3nA:
undetectable		 4kjjA-2g3nA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		4 / 5 MET A 551
LEU A 533
PRO A 528
SER A 435
 None
 1.29A 4kmmB-2g3nA:
undetectable		 4kmmB-2g3nA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		4 / 5 VAL A 149
LEU A  43
VAL A  54
PHE A 147
 None
 0.95A 4lb0B-2g3nA:
undetectable		 4lb0B-2g3nA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_B_SHHB408_1
(HISTONE DEACETYLASE
2)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 11 HIS A 480
ASP A 416
PHE A 449
ASP A 484
GLY A 485
 None
BOG  A2000 (-3.0A)
None
None
None
 1.34A 4lxzB-2g3nA:
undetectable		 4lxzB-2g3nA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_1
(PROTEASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		6 / 11 ARG A 154
GLY A 115
ILE A 102
GLY A  66
ILE A  65
PRO A 528
 None
 1.38A 4njvC-2g3nA:
undetectable		 4njvC-2g3nA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 11 GLY A 451
GLY A 485
THR A 488
ASP A 484
ILE A 457
 None
 1.15A 4pghA-2g3nA:
undetectable		 4pghA-2g3nA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A 451
GLY A 485
THR A 488
ASP A 484
ILE A 457
 None
 1.14A 4pghD-2g3nA:
undetectable		 4pghD-2g3nA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 ILE A 395
ALA A 410
ALA A 382
PHE A 384
LYS A 385
 None
 0.88A 4psyA-2g3nA:
undetectable		 4psyA-2g3nA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		4 / 8 THR A 414
LEU A 426
LEU A 470
GLY A 443
 None
 0.86A 4r3aA-2g3nA:
undetectable		 4r3aA-2g3nA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		3 / 3 GLU A 521
TYR A 535
GLU A 536
 None
 0.73A 4ryaA-2g3nA:
undetectable		 4ryaA-2g3nA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		3 / 3 VAL A 439
LEU A 434
VAL A 442
 None
 0.60A 4wq4A-2g3nA:
undetectable		 4wq4A-2g3nA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		3 / 3 MET A 321
ASP A 212
PHE A 210
 BOG  A2000 ( 4.0A)
None
None
 1.06A 4xeyA-2g3nA:
1.3		 4xeyA-2g3nA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		4 / 5 ASP A 347
VAL A  86
ASP A  87
GLY A  89
 None
None
BOG  A2000 (-2.7A)
BOG  A2000 ( 4.2A)
 1.21A 4xp6A-2g3nA:
undetectable		 4xp6A-2g3nA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 11 THR A 414
GLY A 415
ASP A  87
GLU A  69
THR A 325
 None
None
BOG  A2000 (-2.7A)
None
None
 1.46A 4xt7A-2g3nA:
undetectable		 4xt7A-2g3nA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		4 / 7 ILE A 140
PHE A 118
VAL A  52
ILE A  45
 None
 0.95A 4zzbC-2g3nA:
undetectable
4zzbD-2g3nA:
undetectable		 4zzbC-2g3nA:
18.94
4zzbD-2g3nA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 11 PHE A 117
ILE A 102
LEU A 430
LEU A  67
GLY A  66
 None
 1.19A 5fctA-2g3nA:
undetectable		 5fctA-2g3nA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		4 / 5 LEU A 556
LEU A 610
PHE A 473
LEU A 507
 None
 0.85A 5gtrA-2g3nA:
undetectable		 5gtrA-2g3nA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEF_A_NBVA1005_1
(NEUTRAL
ALPHA-GLUCOSIDASE AB)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		9 / 12 ASP A 212
ILE A 213
ILE A 249
TRP A 318
ASP A 320
MET A 321
ASP A 416
PHE A 449
HIS A 480
 None
None
None
None
None
BOG  A2000 ( 4.0A)
BOG  A2000 (-3.0A)
None
None
 0.48A 5iefA-2g3nA:
38.3		 5iefA-2g3nA:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEF_A_NBVA1005_1
(NEUTRAL
ALPHA-GLUCOSIDASE AB)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		9 / 12 ASP A 212
ILE A 249
TRP A 318
ASP A 320
MET A 321
PHE A 327
ASP A 416
PHE A 449
HIS A 480
 None
None
None
None
BOG  A2000 ( 4.0A)
None
BOG  A2000 (-3.0A)
None
None
 0.65A 5iefA-2g3nA:
38.3		 5iefA-2g3nA:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEF_A_NBVA1005_2
(NEUTRAL
ALPHA-GLUCOSIDASE AB)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		4 / 4 ARG A 400
TRP A 413
ASP A 445
ARG A 478
 BOG  A2000 (-3.1A)
None
None
None
 0.15A 5iefA-2g3nA:
38.3		 5iefA-2g3nA:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		3 / 3 TYR A  91
TYR A 467
GLN A 427
 None
 1.07A 5jsdA-2g3nA:
undetectable
5jsdB-2g3nA:
undetectable		 5jsdA-2g3nA:
23.38
5jsdB-2g3nA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		3 / 3 TYR A  91
TYR A 467
GLN A 427
 None
 1.06A 5jsdB-2g3nA:
undetectable
5jsdC-2g3nA:
undetectable		 5jsdB-2g3nA:
23.38
5jsdC-2g3nA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		4 / 6 VAL A 491
VAL A 206
ILE A 247
PHE A 210
 None
 1.09A 5jw1B-2g3nA:
undetectable		 5jw1B-2g3nA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1
(ION TRANSPORT
PROTEIN)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 5 TYR A 162
ILE A 150
LEU A  67
GLY A  66
PHE A 105
 None
 1.35A 5kmdC-2g3nA:
undetectable
5kmdD-2g3nA:
undetectable		 5kmdC-2g3nA:
18.91
5kmdD-2g3nA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MM4_B_TA1B501_1
(TUBULIN BETA CHAIN)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 10 VAL A 124
GLU A 142
LEU A 434
PHE A 117
PRO A  23
 None
 1.42A 5mm4B-2g3nA:
0.6		 5mm4B-2g3nA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		3 / 3 THR A 325
HIS A 252
ASN A 322
 None
 0.81A 5n4tA-2g3nA:
2.9		 5n4tA-2g3nA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN6_A_MIGA1013_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		9 / 12 ASP A 212
ILE A 249
TRP A 284
TRP A 318
ASP A 320
MET A 321
TRP A 413
PHE A 449
HIS A 480
 None
None
None
None
None
BOG  A2000 ( 4.0A)
None
None
None
 0.85A 5nn6A-2g3nA:
40.5		 5nn6A-2g3nA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN6_A_MIGA1013_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		9 / 12 ASP A 212
ILE A 249
TRP A 284
TRP A 318
ASP A 320
TRP A 413
ASP A 416
PHE A 449
HIS A 480
 None
None
None
None
None
None
BOG  A2000 (-3.0A)
None
None
 0.69A 5nn6A-2g3nA:
40.5		 5nn6A-2g3nA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN8_A_ACRA1015_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 ASP A  87
ASP A 212
ILE A 213
ASP A 416
PHE A 449
 BOG  A2000 (-2.7A)
None
None
BOG  A2000 (-3.0A)
None
 1.47A 5nn8A-2g3nA:
31.4		 5nn8A-2g3nA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN8_A_ACRA1015_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		10 / 12 ASP A  87
ASP A 212
ILE A 249
TRP A 284
TRP A 318
ASP A 320
ARG A 400
ASP A 416
PHE A 449
HIS A 480
 BOG  A2000 (-2.7A)
None
None
None
None
None
BOG  A2000 (-3.1A)
BOG  A2000 (-3.0A)
None
None
 0.54A 5nn8A-2g3nA:
31.4		 5nn8A-2g3nA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN8_A_ACRA1015_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 ASP A  87
ASP A 445
ASP A 416
ASP A 320
HIS A 480
 BOG  A2000 (-2.7A)
None
BOG  A2000 (-3.0A)
None
None
 1.46A 5nn8A-2g3nA:
31.4		 5nn8A-2g3nA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		4 / 7 TYR A 219
ASP A 326
HIS A 252
TYR A 184
 None
None
None
BOG  A2000 (-4.5A)
 1.27A 5ov9B-2g3nA:
undetectable		 5ov9B-2g3nA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		4 / 8 ILE A 254
TYR A 375
TRP A 302
VAL A 250
 None
 1.03A 5vlmF-2g3nA:
undetectable		 5vlmF-2g3nA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1401_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		7 / 10 TRP A 318
ASP A 320
ARG A 400
TRP A 413
ASP A 416
PHE A 449
HIS A 480
 None
None
BOG  A2000 (-3.1A)
None
BOG  A2000 (-3.0A)
None
None
 0.42A 5x7pA-2g3nA:
17.7		 5x7pA-2g3nA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 SER A 479
LEU A 464
ILE A 504
LEU A 195
TYR A 186
 None
 1.06A 5ycpA-2g3nA:
undetectable		 5ycpA-2g3nA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA410_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		4 / 4 GLY A  68
LEU A 434
VAL A 100
GLU A  69
 None
 1.25A 5yw0A-2g3nA:
undetectable		 5yw0A-2g3nA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		3 / 3 ARG A 400
ARG A 372
ARG A 348
 BOG  A2000 (-3.1A)
None
BOG  A2000 (-3.9A)
 0.89A 6bplA-2g3nA:
undetectable
6bplB-2g3nA:
undetectable		 6bplA-2g3nA:
8.21
6bplB-2g3nA:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9X_A_VOGA701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		10 / 12 ASP A  87
ILE A 213
ILE A 249
TRP A 284
ASP A 320
MET A 321
ARG A 400
TRP A 413
PHE A 449
HIS A 480
 BOG  A2000 (-2.7A)
None
None
None
None
BOG  A2000 ( 4.0A)
BOG  A2000 (-3.1A)
None
None
None
 0.47A 6c9xA-2g3nA:
42.7		 6c9xA-2g3nA:
27.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9X_A_VOGA701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		6 / 12 ASP A  87
ILE A 249
MET A 321
ARG A 400
PHE A 449
HIS A 480
 BOG  A2000 (-2.7A)
None
BOG  A2000 ( 4.0A)
BOG  A2000 (-3.1A)
None
None
 1.19A 6c9xA-2g3nA:
42.7		 6c9xA-2g3nA:
27.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9X_A_VOGA701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		7 / 12 ILE A 213
ILE A 249
TRP A 284
TRP A 318
TRP A 413
PHE A 449
HIS A 480
 None
 1.00A 6c9xA-2g3nA:
42.7		 6c9xA-2g3nA:
27.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9X_B_VOGB701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		10 / 12 ASP A  87
ILE A 213
ILE A 249
TRP A 284
ASP A 320
MET A 321
ARG A 400
TRP A 413
PHE A 449
HIS A 480
 BOG  A2000 (-2.7A)
None
None
None
None
BOG  A2000 ( 4.0A)
BOG  A2000 (-3.1A)
None
None
None
 0.49A 6c9xB-2g3nA:
42.7		 6c9xB-2g3nA:
27.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9X_B_VOGB701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		6 / 12 ASP A  87
ILE A 249
MET A 321
ARG A 400
PHE A 449
HIS A 480
 BOG  A2000 (-2.7A)
None
BOG  A2000 ( 4.0A)
BOG  A2000 (-3.1A)
None
None
 1.18A 6c9xB-2g3nA:
42.7		 6c9xB-2g3nA:
27.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9X_B_VOGB701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		7 / 12 ILE A 213
ILE A 249
TRP A 284
TRP A 318
TRP A 413
PHE A 449
HIS A 480
 None
 1.01A 6c9xB-2g3nA:
42.7		 6c9xB-2g3nA:
27.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9Z_A_VOGA701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 ILE A 249
MET A 321
ARG A 400
ASP A 416
PHE A 449
 None
BOG  A2000 ( 4.0A)
BOG  A2000 (-3.1A)
BOG  A2000 (-3.0A)
None
 0.94A 6c9zA-2g3nA:
41.5		 6c9zA-2g3nA:
27.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9Z_A_VOGA701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		11 / 12 TYR A 184
ILE A 213
ILE A 249
TRP A 284
ASP A 320
MET A 321
ARG A 400
TRP A 413
ASP A 416
PHE A 449
HIS A 480
 BOG  A2000 (-4.5A)
None
None
None
None
BOG  A2000 ( 4.0A)
BOG  A2000 (-3.1A)
None
BOG  A2000 (-3.0A)
None
None
 0.59A 6c9zA-2g3nA:
41.5		 6c9zA-2g3nA:
27.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9Z_A_VOGA701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		8 / 12 TYR A 184
ILE A 213
ILE A 249
TRP A 284
TRP A 318
TRP A 413
PHE A 449
HIS A 480
 BOG  A2000 (-4.5A)
None
None
None
None
None
None
None
 1.05A 6c9zA-2g3nA:
41.5		 6c9zA-2g3nA:
27.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9Z_B_VOGB701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 ASP A  87
ILE A 213
MET A 321
PHE A 449
HIS A 480
 BOG  A2000 (-2.7A)
None
BOG  A2000 ( 4.0A)
None
None
 1.48A 6c9zB-2g3nA:
42.5		 6c9zB-2g3nA:
27.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9Z_B_VOGB701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 ASP A  87
ILE A 249
MET A 321
ARG A 400
PHE A 449
 BOG  A2000 (-2.7A)
None
BOG  A2000 ( 4.0A)
BOG  A2000 (-3.1A)
None
 1.06A 6c9zB-2g3nA:
42.5		 6c9zB-2g3nA:
27.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9Z_B_VOGB701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		11 / 12 ASP A  87
TYR A 184
ILE A 213
ILE A 249
TRP A 284
ASP A 320
MET A 321
ARG A 400
TRP A 413
PHE A 449
HIS A 480
 BOG  A2000 (-2.7A)
BOG  A2000 (-4.5A)
None
None
None
None
BOG  A2000 ( 4.0A)
BOG  A2000 (-3.1A)
None
None
None
 0.57A 6c9zB-2g3nA:
42.5		 6c9zB-2g3nA:
27.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9Z_B_VOGB701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		8 / 12 TYR A 184
ILE A 213
ILE A 249
TRP A 284
TRP A 318
TRP A 413
PHE A 449
HIS A 480
 BOG  A2000 (-4.5A)
None
None
None
None
None
None
None
 1.03A 6c9zB-2g3nA:
42.5		 6c9zB-2g3nA:
27.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		10 / 12 ASP A 212
ILE A 213
ILE A 249
ASP A 320
MET A 321
ARG A 400
TRP A 413
ASP A 416
PHE A 449
HIS A 480
 None
None
None
None
BOG  A2000 ( 4.0A)
BOG  A2000 (-3.1A)
None
BOG  A2000 (-3.0A)
None
None
 0.38A 6ca1A-2g3nA:
41.6		 6ca1A-2g3nA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		7 / 12 ASP A 212
ILE A 213
ILE A 249
TRP A 318
TRP A 413
PHE A 449
HIS A 480
 None
 0.86A 6ca1A-2g3nA:
41.6		 6ca1A-2g3nA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		7 / 12 ASP A 212
ILE A 249
MET A 321
ARG A 400
ASP A 416
PHE A 449
HIS A 480
 None
None
BOG  A2000 ( 4.0A)
BOG  A2000 (-3.1A)
BOG  A2000 (-3.0A)
None
None
 1.36A 6ca1A-2g3nA:
41.6		 6ca1A-2g3nA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		10 / 12 ASP A 212
ILE A 213
ILE A 249
ASP A 320
MET A 321
ARG A 400
TRP A 413
ASP A 416
PHE A 449
HIS A 480
 None
None
None
None
BOG  A2000 ( 4.0A)
BOG  A2000 (-3.1A)
None
BOG  A2000 (-3.0A)
None
None
 0.34A 6ca1B-2g3nA:
41.8		 6ca1B-2g3nA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		7 / 12 ASP A 212
ILE A 213
ILE A 249
TRP A 318
TRP A 413
PHE A 449
HIS A 480
 None
 0.84A 6ca1B-2g3nA:
41.8		 6ca1B-2g3nA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		7 / 12 ASP A 212
ILE A 249
MET A 321
ARG A 400
ASP A 416
PHE A 449
HIS A 480
 None
None
BOG  A2000 ( 4.0A)
BOG  A2000 (-3.1A)
BOG  A2000 (-3.0A)
None
None
 1.39A 6ca1B-2g3nA:
41.8		 6ca1B-2g3nA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		6 / 12 ASP A 212
ILE A 249
MET A 321
ARG A 400
ASP A 416
PHE A 449
 None
None
BOG  A2000 ( 4.0A)
BOG  A2000 (-3.1A)
BOG  A2000 (-3.0A)
None
 1.42A 6ca3A-2g3nA:
42.7		 6ca3A-2g3nA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		11 / 12 TYR A 184
ASP A 212
ILE A 213
ILE A 249
ASP A 320
MET A 321
ARG A 400
TRP A 413
ASP A 416
PHE A 449
HIS A 480
 BOG  A2000 (-4.5A)
None
None
None
None
BOG  A2000 ( 4.0A)
BOG  A2000 (-3.1A)
None
BOG  A2000 (-3.0A)
None
None
 0.45A 6ca3A-2g3nA:
42.7		 6ca3A-2g3nA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		8 / 12 TYR A 184
ASP A 212
ILE A 213
ILE A 249
TRP A 318
TRP A 413
PHE A 449
HIS A 480
 BOG  A2000 (-4.5A)
None
None
None
None
None
None
None
 0.88A 6ca3A-2g3nA:
42.7		 6ca3A-2g3nA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		10 / 12 ASP A 212
ILE A 213
ILE A 249
ASP A 320
MET A 321
ARG A 400
TRP A 413
ASP A 416
PHE A 449
HIS A 480
 None
None
None
None
BOG  A2000 ( 4.0A)
BOG  A2000 (-3.1A)
None
BOG  A2000 (-3.0A)
None
None
 0.40A 6ca3B-2g3nA:
41.7		 6ca3B-2g3nA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		9 / 12 ASP A 212
ILE A 213
ILE A 249
TRP A 284
ASP A 320
TRP A 413
ASP A 416
PHE A 449
HIS A 480
 None
None
None
None
None
None
BOG  A2000 (-3.0A)
None
None
 0.85A 6ca3B-2g3nA:
41.7		 6ca3B-2g3nA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		8 / 12 ASP A 212
ILE A 213
ILE A 249
TRP A 284
TRP A 318
TRP A 413
PHE A 449
HIS A 480
 None
 1.24A 6ca3B-2g3nA:
41.7		 6ca3B-2g3nA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		6 / 12 ASP A 212
ILE A 249
MET A 321
ARG A 400
ASP A 416
PHE A 449
 None
None
BOG  A2000 ( 4.0A)
BOG  A2000 (-3.1A)
BOG  A2000 (-3.0A)
None
 1.43A 6ca3B-2g3nA:
41.7		 6ca3B-2g3nA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		3 / 3 HIS A 252
ASN A 322
LEU A 319
 None
 0.83A 6f7lB-2g3nA:
undetectable		 6f7lB-2g3nA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		4 / 7 ASP A  87
ARG A 400
GLN A  95
TYR A  91
 BOG  A2000 (-2.7A)
BOG  A2000 (-3.1A)
None
None
 1.29A 6g31G-2g3nA:
undetectable		 6g31G-2g3nA:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		4 / 5 LEU A 165
TYR A 162
ILE A 125
GLY A 405
 None
 1.09A 6hd6A-2g3nA:
undetectable		 6hd6A-2g3nA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		4 / 8 ASP A 487
ILE A 486
ARG A 183
TYR A 468
 None
 1.01A 6hisA-2g3nA:
undetectable
6hisB-2g3nA:
undetectable		 6hisA-2g3nA:
8.36
6hisB-2g3nA:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		4 / 8 ASP A 487
ILE A 486
ARG A 183
TYR A 468
 None
 1.01A 6hisB-2g3nA:
undetectable
6hisC-2g3nA:
undetectable		 6hisB-2g3nA:
8.36
6hisC-2g3nA:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		4 / 8 ASP A 487
ILE A 486
ARG A 183
TYR A 468
 None
 1.00A 6hisC-2g3nA:
undetectable
6hisD-2g3nA:
undetectable		 6hisC-2g3nA:
8.36
6hisD-2g3nA:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		4 / 8 ASP A 487
ILE A 486
ARG A 183
TYR A 468
 None
 1.02A 6hisD-2g3nA:
undetectable
6hisE-2g3nA:
undetectable		 6hisD-2g3nA:
8.36
6hisE-2g3nA:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		4 / 8 TYR A 468
ASP A 487
ILE A 486
ARG A 183
 None
 1.01A 6hisA-2g3nA:
undetectable
6hisE-2g3nA:
undetectable		 6hisA-2g3nA:
8.36
6hisE-2g3nA:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 10 PHE A 117
ILE A 102
LEU A 430
LEU A  67
GLY A  66
 None
 1.23A 6r2eB-2g3nA:
undetectable		 6r2eB-2g3nA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 11 PHE A 117
ILE A 102
LEU A 430
LEU A  67
GLY A  66
 None
 1.09A 6r2eF-2g3nA:
undetectable		 6r2eF-2g3nA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 2g3n ALPHA-GLUCOSIDASE
(Sulfolobus
solfataricus) 		5 / 11 PHE A 117
ILE A 102
LEU A 430
LEU A  67
GLY A  66
 None
 1.19A 6r2eG-2g3nA:
undetectable		 6r2eG-2g3nA:
21.16