SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2g40'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 2g40 CONSERVED
HYPOTHETICAL PROTEIN
(Deinococcus
radiodurans) 		4 / 4 LEU A 117
LEU A 143
SER A 144
LEU A 132
 None
 0.96A 1ya3A-2g40A:
undetectable		 1ya3A-2g40A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_3
(POL POLYPROTEIN)		 2g40 CONSERVED
HYPOTHETICAL PROTEIN
(Deinococcus
radiodurans) 		5 / 12 GLY A  56
ALA A  57
VAL A 208
ILE A 130
GLY A 128
 None
 0.87A 2avvB-2g40A:
undetectable		 2avvB-2g40A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1
(SERUM ALBUMIN)		 2g40 CONSERVED
HYPOTHETICAL PROTEIN
(Deinococcus
radiodurans) 		4 / 5 LEU A 117
LEU A  67
ILE A 209
ALA A  72
 None
 0.60A 2i2zA-2g40A:
undetectable		 2i2zA-2g40A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		 2g40 CONSERVED
HYPOTHETICAL PROTEIN
(Deinococcus
radiodurans) 		5 / 12 ALA A  74
LEU A  75
ALA A  72
THR A  93
ILE A  87
 None
 1.09A 2jjpA-2g40A:
undetectable		 2jjpA-2g40A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_2
(PROTEASE)		 2g40 CONSERVED
HYPOTHETICAL PROTEIN
(Deinococcus
radiodurans) 		5 / 12 GLY A  56
ALA A  57
VAL A 208
ILE A 130
GLY A 128
 None
 0.88A 3el1B-2g40A:
undetectable		 3el1B-2g40A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 2g40 CONSERVED
HYPOTHETICAL PROTEIN
(Deinococcus
radiodurans) 		3 / 3 VAL A 167
VAL A 174
TRP A 182
 None
 0.91A 3l8lA-2g40A:
undetectable
3l8lB-2g40A:
undetectable		 3l8lA-2g40A:
9.57
3l8lB-2g40A:
6.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2g40 CONSERVED
HYPOTHETICAL PROTEIN
(Deinococcus
radiodurans) 		5 / 12 ALA A  74
HIS A 150
ILE A  87
PRO A  84
LEU A  67
 None
 1.20A 3nrrB-2g40A:
undetectable		 3nrrB-2g40A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_2
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 2g40 CONSERVED
HYPOTHETICAL PROTEIN
(Deinococcus
radiodurans) 		4 / 4 PRO A 104
LEU A 143
HIS A 134
LEU A 180
 None
 1.42A 3vw7A-2g40A:
undetectable		 3vw7A-2g40A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)		 2g40 CONSERVED
HYPOTHETICAL PROTEIN
(Deinococcus
radiodurans) 		5 / 9 ALA A  64
ALA A  70
GLY A  69
ILE A  71
ILE A 209
 None
 0.98A 4eatB-2g40A:
undetectable		 4eatB-2g40A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2g40 CONSERVED
HYPOTHETICAL PROTEIN
(Deinococcus
radiodurans) 		5 / 12 VAL A 210
LEU A 206
PHE A  48
SER A 125
VAL A 154
 None
 1.18A 4eckB-2g40A:
undetectable		 4eckB-2g40A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 2g40 CONSERVED
HYPOTHETICAL PROTEIN
(Deinococcus
radiodurans) 		5 / 11 ILE A 130
ALA A  57
ALA A  58
ILE A 209
VAL A 154
 None
 1.12A 4h1nA-2g40A:
undetectable		 4h1nA-2g40A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_1
(PROTEASE)		 2g40 CONSERVED
HYPOTHETICAL PROTEIN
(Deinococcus
radiodurans) 		5 / 11 GLY A  56
ALA A  57
ILE A 130
THR A 129
GLY A 128
 None
 0.74A 4qgiA-2g40A:
undetectable		 4qgiA-2g40A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2g40 CONSERVED
HYPOTHETICAL PROTEIN
(Deinococcus
radiodurans) 		4 / 6 ARG A  41
ASP A 157
ARG A 155
GLY A 212
 None
 0.97A 5cdqA-2g40A:
undetectable
5cdqC-2g40A:
undetectable
5cdqD-2g40A:
undetectable		 5cdqA-2g40A:
20.55
5cdqC-2g40A:
20.55
5cdqD-2g40A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 2g40 CONSERVED
HYPOTHETICAL PROTEIN
(Deinococcus
radiodurans) 		4 / 8 TYR A  55
SER A 184
THR A 127
ILE A 131
 None
 0.83A 5jhdE-2g40A:
undetectable
5jhdG-2g40A:
undetectable		 5jhdE-2g40A:
22.34
5jhdG-2g40A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 2g40 CONSERVED
HYPOTHETICAL PROTEIN
(Deinococcus
radiodurans) 		5 / 12 GLY A 212
VAL A 153
ALA A  65
LEU A  67
ALA A  70
 None
 0.87A 5kpcA-2g40A:
undetectable		 5kpcA-2g40A:
20.69