SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2g46'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)
2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE

(Paramecium
bursaria
Chlorella
virus
1)
5 / 12 GLY A  15
TYR A  16
ASN A  69
HIS A  70
TYR A 105
None
SAH  A 301 (-4.7A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
1.14A 3qxyA-2g46A:
6.7
3qxyA-2g46A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)
2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE

(Paramecium
bursaria
Chlorella
virus
1)
5 / 12 GLY A  15
TYR A  16
ASN A  69
HIS A  70
TYR A 105
None
SAH  A 301 (-4.7A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
1.16A 3rc0B-2g46A:
6.7
3rc0B-2g46A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE

(Paramecium
bursaria
Chlorella
virus
1)
5 / 12 GLY A  15
TYR A  50
ASN A  69
HIS A  70
TYR A 105
None
SAH  A 301 (-3.1A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
1.12A 4ypuA-2g46A:
7.3
4ypuA-2g46A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE

(Paramecium
bursaria
Chlorella
virus
1)
5 / 12 GLY A  15
TYR A  50
ASN A  69
HIS A  70
TYR A 105
None
SAH  A 301 (-3.1A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
1.06A 5jhnA-2g46A:
8.6
5jhnA-2g46A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE

(Paramecium
bursaria
Chlorella
virus
1)
5 / 12 GLY A  15
TYR A  50
ASN A  69
HIS A  70
TYR A 105
None
SAH  A 301 (-3.1A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
1.06A 5jhnB-2g46A:
7.6
5jhnB-2g46A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIY_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE

(Paramecium
bursaria
Chlorella
virus
1)
5 / 12 GLY A  15
TYR A  50
ASN A  69
HIS A  70
TYR A 105
None
SAH  A 301 (-3.1A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
1.06A 5jiyA-2g46A:
7.4
5jiyA-2g46A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIY_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE

(Paramecium
bursaria
Chlorella
virus
1)
5 / 12 GLY A  15
TYR A  50
ASN A  69
HIS A  70
TYR A 105
None
SAH  A 301 (-3.1A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
1.06A 5jiyB-2g46A:
7.5
5jiyB-2g46A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKL_B_SAMB8009_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN,HISTONE H3.1
PEPTIDE,ZINC FINGER
DOMAIN-CONTAINING
PROTEIN)
2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE

(Paramecium
bursaria
Chlorella
virus
1)
5 / 12 GLY A  15
TYR A  16
ASN A  69
HIS A  70
LEU A 111
None
SAH  A 301 (-4.7A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
SAH  A 301 (-4.4A)
1.38A 5kklB-2g46A:
8.3
5kklB-2g46A:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKL_B_SAMB8009_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN,HISTONE H3.1
PEPTIDE,ZINC FINGER
DOMAIN-CONTAINING
PROTEIN)
2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE

(Paramecium
bursaria
Chlorella
virus
1)
5 / 12 GLY A  15
TYR A  16
ASN A  69
HIS A  70
TYR A 105
None
SAH  A 301 (-4.7A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
1.04A 5kklB-2g46A:
8.3
5kklB-2g46A:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE

(Paramecium
bursaria
Chlorella
virus
1)
5 / 12 GLY A  15
TYR A  50
ASN A  69
HIS A  70
TYR A 105
None
SAH  A 301 (-3.1A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
1.11A 5t0kA-2g46A:
7.5
5t0kA-2g46A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0M_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE

(Paramecium
bursaria
Chlorella
virus
1)
5 / 12 GLY A  15
TYR A  50
ASN A  69
HIS A  70
TYR A 105
None
SAH  A 301 (-3.1A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
1.07A 5t0mB-2g46A:
7.4
5t0mB-2g46A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TQR_B_SAMB8009_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2, POLYCOMB
PROTEIN SUZ12)
2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE

(Paramecium
bursaria
Chlorella
virus
1)
5 / 10 GLY A  15
TYR A  16
ASN A  69
HIS A  70
TYR A 105
None
SAH  A 301 (-4.7A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
1.08A 5tqrB-2g46A:
6.4
5tqrB-2g46A:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TQR_B_SAMB8009_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2, POLYCOMB
PROTEIN SUZ12)
2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE

(Paramecium
bursaria
Chlorella
virus
1)
5 / 10 TYR A  16
TYR A  50
ASN A  69
HIS A  70
TYR A 105
SAH  A 301 (-4.7A)
SAH  A 301 (-3.1A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
0.90A 5tqrB-2g46A:
6.4
5tqrB-2g46A:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE

(Paramecium
bursaria
Chlorella
virus
1)
5 / 11 GLY A  15
TYR A  50
ASN A  69
HIS A  70
TYR A 105
None
SAH  A 301 (-3.1A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
1.08A 5ttfA-2g46A:
7.8
5ttfA-2g46A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE

(Paramecium
bursaria
Chlorella
virus
1)
5 / 12 GLY A  15
TYR A  50
ASN A  69
HIS A  70
TYR A 105
None
SAH  A 301 (-3.1A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
1.06A 5ttfB-2g46A:
7.5
5ttfB-2g46A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE

(Paramecium
bursaria
Chlorella
virus
1)
5 / 11 GLY A  15
TYR A  50
ASN A  69
HIS A  70
TYR A 105
None
SAH  A 301 (-3.1A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
1.11A 5ttfD-2g46A:
8.8
5ttfD-2g46A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE

(Paramecium
bursaria
Chlorella
virus
1)
5 / 12 GLY A  15
TYR A  50
ASN A  69
HIS A  70
TYR A 105
None
SAH  A 301 (-3.1A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
1.11A 5ttgA-2g46A:
8.6
5ttgA-2g46A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE

(Paramecium
bursaria
Chlorella
virus
1)
5 / 11 GLY A  15
TYR A  50
ASN A  69
HIS A  70
TYR A 105
None
SAH  A 301 (-3.1A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
1.12A 5ttgB-2g46A:
8.5
5ttgB-2g46A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE

(Paramecium
bursaria
Chlorella
virus
1)
5 / 12 GLY A  15
TYR A  50
ASN A  69
HIS A  70
TYR A 105
None
SAH  A 301 (-3.1A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
1.06A 5tuyA-2g46A:
7.4
5tuyA-2g46A:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE

(Paramecium
bursaria
Chlorella
virus
1)
5 / 12 GLY A  15
TYR A  50
ASN A  69
HIS A  70
TYR A 105
None
SAH  A 301 (-3.1A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
1.06A 5tuyB-2g46A:
8.8
5tuyB-2g46A:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUZ_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE

(Paramecium
bursaria
Chlorella
virus
1)
5 / 12 GLY A  15
TYR A  50
ASN A  69
HIS A  70
TYR A 105
None
SAH  A 301 (-3.1A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
1.14A 5tuzB-2g46A:
8.5
5tuzB-2g46A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE

(Paramecium
bursaria
Chlorella
virus
1)
5 / 12 GLY A  15
TYR A  50
ASN A  69
HIS A  70
TYR A 105
None
SAH  A 301 (-3.1A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
1.05A 5v9iA-2g46A:
7.5
5v9iA-2g46A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE

(Paramecium
bursaria
Chlorella
virus
1)
5 / 11 GLY A  15
TYR A  50
ASN A  69
HIS A  70
TYR A 105
None
SAH  A 301 (-3.1A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
1.06A 5v9iB-2g46A:
7.5
5v9iB-2g46A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE

(Paramecium
bursaria
Chlorella
virus
1)
5 / 11 GLY A  15
TYR A  50
ASN A  69
HIS A  70
TYR A 105
None
SAH  A 301 (-3.1A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
1.07A 5v9iC-2g46A:
7.7
5v9iC-2g46A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE

(Paramecium
bursaria
Chlorella
virus
1)
5 / 12 GLY A  15
TYR A  50
ASN A  69
HIS A  70
TYR A 105
None
SAH  A 301 (-3.1A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
1.10A 5vscB-2g46A:
8.6
5vscB-2g46A:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSD_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE

(Paramecium
bursaria
Chlorella
virus
1)
5 / 12 GLY A  15
TYR A  50
ASN A  69
HIS A  70
TYR A 105
None
SAH  A 301 (-3.1A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
1.11A 5vsdB-2g46A:
8.6
5vsdB-2g46A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE

(Paramecium
bursaria
Chlorella
virus
1)
5 / 12 GLY A  15
TYR A  50
ASN A  69
HIS A  70
TYR A 105
None
SAH  A 301 (-3.1A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
1.10A 5vseA-2g46A:
7.5
5vseA-2g46A:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE

(Paramecium
bursaria
Chlorella
virus
1)
5 / 12 GLY A  15
TYR A  50
ASN A  69
HIS A  70
TYR A 105
None
SAH  A 301 (-3.1A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
1.10A 5vseB-2g46A:
7.4
5vseB-2g46A:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSF_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
2g46 PBCV-1 HISTONE
H3-LYS 27
METHYLTRANSFERASE

(Paramecium
bursaria
Chlorella
virus
1)
5 / 12 GLY A  15
TYR A  50
ASN A  69
HIS A  70
TYR A 105
None
SAH  A 301 (-3.1A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.8A)
MLZ  C 215 (-3.7A)
1.11A 5vsfB-2g46A:
8.6
5vsfB-2g46A:
22.12