SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2g4b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 2g4b SPLICING FACTOR U2AF
65 KDA SUBUNIT
(Homo
sapiens) 		3 / 3 LEU A 266
PRO A 267
LEU A 270
 None
 0.54A 1hrkA-2g4bA:
undetectable		 1hrkA-2g4bA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 2g4b SPLICING FACTOR U2AF
65 KDA SUBUNIT
(Homo
sapiens) 		5 / 12 PHE A 262
ILE A 263
GLY A 264
VAL A 332
VAL A 275
 None
 0.89A 3fpjA-2g4bA:
undetectable		 3fpjA-2g4bA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)		 2g4b SPLICING FACTOR U2AF
65 KDA SUBUNIT
(Homo
sapiens) 		5 / 12 LEU A 224
THR A 161
ILE A 160
ILE A 226
LEU A 200
 None
 1.24A 3vw1B-2g4bA:
undetectable		 3vw1B-2g4bA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA505_0
(RNA POLYMERASE
3D-POL)		 2g4b SPLICING FACTOR U2AF
65 KDA SUBUNIT
(Homo
sapiens) 		3 / 3 CYH A 305
ASN A 289
LYS A 260
 None
 1.03A 4k50A-2g4bA:
undetectable		 4k50A-2g4bA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 2g4b SPLICING FACTOR U2AF
65 KDA SUBUNIT
(Homo
sapiens) 		5 / 12 GLU A 207
ALA A 211
ALA A 171
GLY A 176
LEU A 175
 None
 0.95A 4oaeA-2g4bA:
undetectable		 4oaeA-2g4bA:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_A_SAMA603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 2g4b SPLICING FACTOR U2AF
65 KDA SUBUNIT
(Homo
sapiens) 		4 / 7 PRO A 234
THR A 313
ILE A 317
ASP A 314
 None
 0.61A 4pcuA-2g4bA:
undetectable		 4pcuA-2g4bA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8T_D_SAMD605_0
(GUANINE-N7
METHYLTRANSFERASE)		 2g4b SPLICING FACTOR U2AF
65 KDA SUBUNIT
(Homo
sapiens) 		5 / 10 GLY A 183
ASN A 184
PRO A 185
ALA A 181
GLN A 180
 None
 1.31A 5c8tD-2g4bA:
undetectable		 5c8tD-2g4bA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CU6_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2g4b SPLICING FACTOR U2AF
65 KDA SUBUNIT
(Homo
sapiens) 		4 / 6 ILE A 191
VAL A 153
PRO A 157
ALA A 198
 None
 0.58A 5cu6A-2g4bA:
undetectable		 5cu6A-2g4bA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 2g4b SPLICING FACTOR U2AF
65 KDA SUBUNIT
(Homo
sapiens) 		5 / 12 ILE A 156
GLY A 154
ALA A 198
PHE A 202
VAL A 189
 None
U  B   4 ( 4.0A)
None
None
None
 1.16A 5hw4A-2g4bA:
undetectable		 5hw4A-2g4bA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 2g4b SPLICING FACTOR U2AF
65 KDA SUBUNIT
(Homo
sapiens) 		5 / 11 ILE A 156
GLY A 154
ALA A 198
PHE A 202
VAL A 189
 None
U  B   4 ( 4.0A)
None
None
None
 1.14A 5hw4B-2g4bA:
undetectable		 5hw4B-2g4bA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 2g4b SPLICING FACTOR U2AF
65 KDA SUBUNIT
(Homo
sapiens) 		5 / 12 ILE A 156
GLY A 154
ALA A 198
PHE A 202
VAL A 189
 None
U  B   4 ( 4.0A)
None
None
None
 1.14A 5hw4C-2g4bA:
undetectable		 5hw4C-2g4bA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSP_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2g4b SPLICING FACTOR U2AF
65 KDA SUBUNIT
(Homo
sapiens) 		5 / 7 VAL A 189
ILE A 191
VAL A 153
PRO A 157
ALA A 198
 None
 0.66A 5ospA-2g4bA:
undetectable		 5ospA-2g4bA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2g4b SPLICING FACTOR U2AF
65 KDA SUBUNIT
(Homo
sapiens) 		4 / 7 ILE A 191
VAL A 153
PRO A 157
ALA A 198
 None
 0.58A 5osrA-2g4bA:
undetectable		 5osrA-2g4bA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2g4b SPLICING FACTOR U2AF
65 KDA SUBUNIT
(Homo
sapiens) 		4 / 7 VAL A 189
ILE A 191
VAL A 153
ALA A 198
 None
 0.51A 5osrA-2g4bA:
undetectable		 5osrA-2g4bA:
18.81