SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2g4o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2g4o 3-ISOPROPYLMALATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 4 ALA A 303
VAL A 307
ALA A 304
HIS A 301
 None
 0.99A 1q23A-2g4oA:
undetectable		 1q23A-2g4oA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2g4o 3-ISOPROPYLMALATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 4 ALA A 303
VAL A 307
ALA A 304
HIS A 301
 None
 0.96A 1q23F-2g4oA:
undetectable		 1q23F-2g4oA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2g4o 3-ISOPROPYLMALATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 4 ALA A 303
VAL A 307
ALA A 304
HIS A 301
 None
 0.99A 1q23K-2g4oA:
undetectable		 1q23K-2g4oA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 2g4o 3-ISOPROPYLMALATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  10
GLY A  12
LEU A  83
LEU A  78
ALA A  39
 None
 1.08A 2egvA-2g4oA:
undetectable		 2egvA-2g4oA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 2g4o 3-ISOPROPYLMALATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 10 LEU A   3
ALA A 292
VAL A  26
VAL A  22
VAL A  27
 None
 1.06A 2nnjA-2g4oA:
undetectable		 2nnjA-2g4oA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 2g4o 3-ISOPROPYLMALATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 10 HIS A 301
ALA A 303
ALA A 305
ALA A 304
SER A 296
 None
 0.98A 2r2vC-2g4oA:
undetectable
2r2vF-2g4oA:
undetectable
2r2vG-2g4oA:
undetectable		 2r2vC-2g4oA:
8.13
2r2vF-2g4oA:
8.13
2r2vG-2g4oA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 2g4o 3-ISOPROPYLMALATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 8 LEU A   3
ILE A   5
LEU A  64
LEU A  23
 None
 0.77A 2xfhA-2g4oA:
undetectable		 2xfhA-2g4oA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y01_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 2g4o 3-ISOPROPYLMALATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 193
THR A 183
VAL A 181
PHE A 233
TYR A 207
 None
 1.42A 2y01B-2g4oA:
undetectable		 2y01B-2g4oA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 2g4o 3-ISOPROPYLMALATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 ASN A 262
ILE A   6
ALA A   7
THR A  16
VAL A  20
 None
 1.22A 3a51E-2g4oA:
undetectable		 3a51E-2g4oA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2g4o 3-ISOPROPYLMALATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		6 / 12 HIS A 270
GLY A   8
GLY A  10
VAL A  15
ASP A  70
LEU A  82
 None
 1.28A 3cjtO-2g4oA:
undetectable		 3cjtO-2g4oA:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 2g4o 3-ISOPROPYLMALATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		3 / 3 CYH A 245
PRO A 103
ASP A 116
 None
 0.69A 3hlwB-2g4oA:
undetectable		 3hlwB-2g4oA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 2g4o 3-ISOPROPYLMALATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A  17
GLU A  18
SER A 326
ALA A 333
ASP A  24
 None
 1.34A 3nmuA-2g4oA:
undetectable
3nmuF-2g4oA:
undetectable		 3nmuA-2g4oA:
23.21
3nmuF-2g4oA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 2g4o 3-ISOPROPYLMALATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		6 / 12 GLY A 254
PRO A 268
VAL A 269
ALA A 287
ALA A  19
LEU A  64
 None
 1.45A 3p2kC-2g4oA:
undetectable		 3p2kC-2g4oA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2g4o 3-ISOPROPYLMALATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		3 / 4 SER A  72
GLY A   8
GLU A 267
 None
 0.62A 3raeA-2g4oA:
undetectable
3raeC-2g4oA:
2.1		 3raeA-2g4oA:
21.40
3raeC-2g4oA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 2g4o 3-ISOPROPYLMALATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  49
ASN A  59
ALA A   4
ILE A   6
ILE A  63
 None
 0.96A 4o2bB-2g4oA:
undetectable		 4o2bB-2g4oA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2g4o 3-ISOPROPYLMALATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 5 ASP A 257
LEU A  90
ARG A  85
THR A 259
 None
 1.49A 4p3qA-2g4oA:
undetectable		 4p3qA-2g4oA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_2
(BETA-LACTAMASE
CTX-M-14)		 2g4o 3-ISOPROPYLMALATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		3 / 3 CYH A 245
PRO A 103
ASP A 116
 None
 0.66A 4pm5A-2g4oA:
undetectable		 4pm5A-2g4oA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2g4o 3-ISOPROPYLMALATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 249
GLY A 247
GLY A 246
ALA A 273
HIS A 270
 None
 0.85A 5c0oF-2g4oA:
undetectable		 5c0oF-2g4oA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2g4o 3-ISOPROPYLMALATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 240
PHE A 117
ILE A 237
ILE A 227
 None
 1.07A 5dzk4-2g4oA:
undetectable
5dzkg-2g4oA:
undetectable
5dzkm-2g4oA:
undetectable
5dzkn-2g4oA:
undetectable		 5dzk4-2g4oA:
0.59
5dzkg-2g4oA:
19.47
5dzkm-2g4oA:
21.47
5dzkn-2g4oA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_1
(PROTEASE E35D-SQV)		 2g4o 3-ISOPROPYLMALATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		6 / 12 ALA A 273
ASP A 275
THR A 325
PRO A 284
VAL A  15
ILE A  11
 None
 1.48A 5kqxA-2g4oA:
undetectable		 5kqxA-2g4oA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)		 2g4o 3-ISOPROPYLMALATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  49
ASN A  59
ALA A   4
ILE A   6
ILE A  63
 None
 0.96A 5mioB-2g4oA:
undetectable		 5mioB-2g4oA:
23.23