SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2g4s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2g4s NEXT TO BRCA1 GENE 1
PROTEIN
(Homo
sapiens) 		4 / 8 GLY A  62
ASN A  59
ILE A  58
ALA A  67
 None
 0.96A 3aodA-2g4sA:
undetectable		 3aodA-2g4sA:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_2
(SECRETED ASPARTIC
PROTEASE)		 2g4s NEXT TO BRCA1 GENE 1
PROTEIN
(Homo
sapiens) 		4 / 6 PRO A  23
SER A  60
THR A  27
THR A  26
 None
 1.06A 3tneA-2g4sA:
undetectable		 3tneA-2g4sA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_A_ECNA403_1
(FLAVOHEMOGLOBIN)		 2g4s NEXT TO BRCA1 GENE 1
PROTEIN
(Homo
sapiens) 		5 / 12 PHE A  18
ALA A  33
VAL A   9
LEU A   7
ILE A  58
 None
 1.09A 4g1bA-2g4sA:
undetectable		 4g1bA-2g4sA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_B_ADNB503_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 2g4s NEXT TO BRCA1 GENE 1
PROTEIN
(Homo
sapiens) 		4 / 5 LEU A   7
VAL A   5
GLU A   2
LEU A  68
 None
None
None
ACY  A  87 (-4.5A)
 1.11A 5xooB-2g4sA:
undetectable		 5xooB-2g4sA:
23.23