SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2g5c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 2g5c PREPHENATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 9 VAL A  36
GLY A  37
ASP A  62
ILE A  63
GLU A 106
 None
NAD  A3686 (-3.6A)
NAD  A3686 (-2.8A)
NAD  A3686 (-3.9A)
NAD  A3686 ( 4.4A)
 0.76A 1cetA-2g5cA:
9.9		 1cetA-2g5cA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 2g5c PREPHENATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 12 VAL A  36
SER A  98
GLY A  60
GLY A  75
ALA A  46
 None
 1.09A 1jg4A-2g5cA:
3.7		 1jg4A-2g5cA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QCA_A_FUAA221_1
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2g5c PREPHENATE
DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 7 THR A 120
PHE A  94
PHE A 143
LEU A 172
 None
 1.00A 1qcaA-2g5cA:
undetectable		 1qcaA-2g5cA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 2g5c PREPHENATE
DEHYDROGENASE
(Aquifex
aeolicus) 		3 / 3 ALA A 150
GLY A 195
SER A  48
 None
 0.53A 2ivuA-2g5cA:
undetectable		 2ivuA-2g5cA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 2g5c PREPHENATE
DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 5 ASP A  62
ILE A  58
ILE A  68
GLY A  37
 NAD  A3686 (-2.8A)
None
None
NAD  A3686 (-3.6A)
 0.90A 3bufA-2g5cA:
undetectable		 3bufA-2g5cA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_A_ADNA439_1
(ADENOSYLHOMOCYSTEINA
SE)		 2g5c PREPHENATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 10 THR A 120
LEU A 172
GLY A 145
MET A  96
PHE A  94
 None
 1.47A 3h9uA-2g5cA:
8.2		 3h9uA-2g5cA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_A_ADNA439_1
(ADENOSYLHOMOCYSTEINA
SE)		 2g5c PREPHENATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 10 THR A 120
LEU A 172
GLY A 146
MET A  96
PHE A  94
 None
 1.13A 3h9uA-2g5cA:
8.2		 3h9uA-2g5cA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 2g5c PREPHENATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 10 THR A 120
LEU A 172
GLY A 145
MET A  96
PHE A  94
 None
 1.47A 3h9uB-2g5cA:
8.3		 3h9uB-2g5cA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 2g5c PREPHENATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 10 THR A 120
LEU A 172
GLY A 146
MET A  96
PHE A  94
 None
 1.16A 3h9uB-2g5cA:
8.3		 3h9uB-2g5cA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 2g5c PREPHENATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 10 THR A 120
LEU A 172
GLY A 145
MET A  96
PHE A  94
 None
 1.50A 3h9uC-2g5cA:
8.3		 3h9uC-2g5cA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 2g5c PREPHENATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 10 THR A 120
LEU A 172
GLY A 146
MET A  96
PHE A  94
 None
 1.17A 3h9uC-2g5cA:
8.3		 3h9uC-2g5cA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 2g5c PREPHENATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 10 THR A 120
LEU A 172
GLY A 145
MET A  96
PHE A  94
 None
 1.49A 3h9uD-2g5cA:
3.5		 3h9uD-2g5cA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 2g5c PREPHENATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 10 THR A 120
LEU A 172
GLY A 146
MET A  96
PHE A  94
 None
 1.17A 3h9uD-2g5cA:
3.5		 3h9uD-2g5cA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_2
(CANDIDAPEPSIN-2)		 2g5c PREPHENATE
DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 6 SER A  98
ILE A  35
ASP A 162
THR A 152
 None
 1.05A 3q70A-2g5cA:
undetectable		 3q70A-2g5cA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2g5c PREPHENATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 12 ALA A 222
LEU A 223
ALA A 273
ILE A 274
LEU A 281
 None
 1.02A 4r3aB-2g5cA:
undetectable		 4r3aB-2g5cA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 2g5c PREPHENATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 12 GLY A  39
SER A  44
ILE A  63
ASN A  64
PRO A 100
 NAD  A3686 (-3.3A)
None
NAD  A3686 (-3.9A)
None
NAD  A3686 (-4.5A)
 1.15A 4rtpA-2g5cA:
5.6		 4rtpA-2g5cA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 2g5c PREPHENATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 12 GLY A  39
ASP A  62
ILE A  63
ASN A  64
PRO A 100
 NAD  A3686 (-3.3A)
NAD  A3686 (-2.8A)
NAD  A3686 (-3.9A)
None
NAD  A3686 (-4.5A)
 0.99A 4rtsA-2g5cA:
5.4		 4rtsA-2g5cA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2g5c PREPHENATE
DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 7 VAL A  87
ILE A 114
LEU A 135
LEU A 139
 None
 1.00A 4xo7A-2g5cA:
undetectable		 4xo7A-2g5cA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 2g5c PREPHENATE
DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 7 ARG A 142
VAL A 121
LEU A 111
SER A 112
 None
 0.87A 4zphA-2g5cA:
undetectable
4zphB-2g5cA:
undetectable		 4zphA-2g5cA:
21.70
4zphB-2g5cA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2g5c PREPHENATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 10 PHE A 248
ALA A 222
LEU A 223
ILE A 288
LEU A 296
 None
 1.02A 5oy01-2g5cA:
undetectable
5oy07-2g5cA:
2.0		 5oy01-2g5cA:
15.24
5oy07-2g5cA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2g5c PREPHENATE
DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 8 VAL A 132
GLU A 136
HIS A 205
LEU A 183
 None
 0.83A 5w3jB-2g5cA:
4.4		 5w3jB-2g5cA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_1
(SERUM ALBUMIN)		 2g5c PREPHENATE
DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 5 TYR A  61
VAL A  87
LEU A  34
SER A  99
 NAD  A3686 (-4.2A)
None
None
NAD  A3686 (-4.6A)
 1.24A 6a7pA-2g5cA:
undetectable		 6a7pA-2g5cA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_0
(ADENOSYLHOMOCYSTEINA
SE)		 2g5c PREPHENATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 12 THR A 120
LEU A 172
GLY A 145
MET A  96
PHE A  94
 None
 1.45A 6exiA-2g5cA:
8.0		 6exiA-2g5cA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_0
(ADENOSYLHOMOCYSTEINA
SE)		 2g5c PREPHENATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 12 THR A 120
LEU A 172
GLY A 146
MET A  96
PHE A  94
 None
 1.13A 6exiA-2g5cA:
8.0		 6exiA-2g5cA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_0
(ADENOSYLHOMOCYSTEINA
SE)		 2g5c PREPHENATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 12 THR A 120
LEU A 172
GLY A 146
MET A  96
PHE A  94
 None
 1.13A 6exiD-2g5cA:
8.1		 6exiD-2g5cA:
14.18