SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2g5d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2g5d GNA33
(Neisseria
gonorrhoeae) 		5 / 12 ILE A 246
ALA A 244
LEU A 256
PRO A 253
ILE A 159
 None
 0.99A 1dhjB-2g5dA:
undetectable		 1dhjB-2g5dA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		 2g5d GNA33
(Neisseria
gonorrhoeae) 		5 / 9 HIS A 260
LEU A 256
ALA A 250
LEU A 145
LEU A 267
 None
 1.42A 1hwiA-2g5dA:
undetectable		 1hwiA-2g5dA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2g5d GNA33
(Neisseria
gonorrhoeae) 		4 / 5 LEU A 372
GLY A 139
ALA A 391
ILE A 389
 None
 0.82A 2aohB-2g5dA:
undetectable		 2aohB-2g5dA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		 2g5d GNA33
(Neisseria
gonorrhoeae) 		4 / 7 GLY A 278
PHE A 334
ASP A 281
TYR A 279
 None
 1.12A 2aouB-2g5dA:
undetectable		 2aouB-2g5dA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 2g5d GNA33
(Neisseria
gonorrhoeae) 		5 / 12 ILE A 246
ALA A 244
ILE A 235
LEU A 256
ILE A 159
 None
 1.03A 2cd2A-2g5dA:
undetectable		 2cd2A-2g5dA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_G_RBFG200_1
(DODECIN)		 2g5d GNA33
(Neisseria
gonorrhoeae) 		4 / 8 ARG A 387
HIS A  71
GLN A  75
THR A 381
 None
 1.09A 2vxaF-2g5dA:
undetectable
2vxaG-2g5dA:
undetectable
2vxaI-2g5dA:
undetectable		 2vxaF-2g5dA:
9.07
2vxaG-2g5dA:
9.07
2vxaI-2g5dA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 2g5d GNA33
(Neisseria
gonorrhoeae) 		4 / 4 GLY A 129
VAL A 127
GLY A 425
THR A 376
 None
 0.84A 3ib2A-2g5dA:
undetectable		 3ib2A-2g5dA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2g5d GNA33
(Neisseria
gonorrhoeae) 		5 / 12 PHE A 105
ALA A  89
THR A 351
ILE A 389
MET A 354
 None
 1.17A 3ld6A-2g5dA:
undetectable		 3ld6A-2g5dA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 2g5d GNA33
(Neisseria
gonorrhoeae) 		4 / 5 TYR A  61
GLN A 429
ILE A 389
LEU A 372
 None
 1.17A 3ls4L-2g5dA:
undetectable		 3ls4L-2g5dA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)		 2g5d GNA33
(Neisseria
gonorrhoeae) 		4 / 6 ILE A 235
ASN A 283
PRO A 163
LEU A 240
 None
 1.16A 3oi8A-2g5dA:
undetectable		 3oi8A-2g5dA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 2g5d GNA33
(Neisseria
gonorrhoeae) 		3 / 3 ARG A 156
PHE A 157
PRO A 158
 None
 0.85A 3zoaB-2g5dA:
undetectable		 3zoaB-2g5dA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2g5d GNA33
(Neisseria
gonorrhoeae) 		5 / 12 ILE A 246
ALA A 244
LEU A 256
PRO A 253
ILE A 159
 None
 0.90A 4p3qA-2g5dA:
undetectable		 4p3qA-2g5dA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2g5d GNA33
(Neisseria
gonorrhoeae) 		3 / 3 ASP A 393
LYS A 343
LEU A 337
 None
 1.08A 4ptjA-2g5dA:
undetectable		 4ptjA-2g5dA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2g5d GNA33
(Neisseria
gonorrhoeae) 		5 / 11 TYR A 279
SER A 396
LYS A 399
ALA A 212
GLU A 284
 None
 1.35A 4zjoD-2g5dA:
undetectable		 4zjoD-2g5dA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2g5d GNA33
(Neisseria
gonorrhoeae) 		4 / 7 ILE A 246
GLY A 248
LEU A 321
PHE A 257
 None
 0.87A 5hieB-2g5dA:
undetectable		 5hieB-2g5dA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2g5d GNA33
(Neisseria
gonorrhoeae) 		5 / 12 VAL A 404
LEU A  91
GLY A 369
ALA A 391
LEU A 372
 None
 1.28A 5iktB-2g5dA:
undetectable		 5iktB-2g5dA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_1
(SCRFP-TAG,GP41)		 2g5d GNA33
(Neisseria
gonorrhoeae) 		5 / 12 GLY A 291
ASN A 317
GLN A 319
LEU A 321
GLU A 323
 None
 0.97A 5nwwA-2g5dA:
undetectable		 5nwwA-2g5dA:
6.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 2g5d GNA33
(Neisseria
gonorrhoeae) 		3 / 3 LYS A 436
VAL A  54
ASP A  48
 None
 0.70A 6fgdA-2g5dA:
undetectable		 6fgdA-2g5dA:
23.73