SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2g5x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 2g5x RIBOSOME-INACTIVATIN
G PROTEIN
(Silene
chalcedonica) 		7 / 9 TYR A  69
PHE A  88
TYR A 119
ILE A 165
ALA A 169
GLU A 170
ARG A 173
 None
 0.70A 1mrgA-2g5xA:
25.6		 1mrgA-2g5xA:
29.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 2g5x RIBOSOME-INACTIVATIN
G PROTEIN
(Silene
chalcedonica) 		5 / 8 TYR A  69
TYR A 119
ILE A 165
GLU A 170
ARG A 173
 None
 0.64A 1mrjA-2g5xA:
24.9		 1mrjA-2g5xA:
27.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2g5x RIBOSOME-INACTIVATIN
G PROTEIN
(Silene
chalcedonica) 		3 / 3 ILE A  59
LEU A  50
VAL A   6
 None
 0.50A 1mz9B-2g5xA:
undetectable		 1mz9B-2g5xA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2g5x RIBOSOME-INACTIVATIN
G PROTEIN
(Silene
chalcedonica) 		4 / 6 GLY A 136
ILE A 163
VAL A   6
SER A 164
 None
 1.05A 1rs7B-2g5xA:
undetectable		 1rs7B-2g5xA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)		 2g5x RIBOSOME-INACTIVATIN
G PROTEIN
(Silene
chalcedonica) 		5 / 12 LEU A 135
PHE A 190
ILE A 196
ILE A 177
ALA A 171
 None
 1.03A 2bxqA-2g5xA:
undetectable		 2bxqA-2g5xA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 2g5x RIBOSOME-INACTIVATIN
G PROTEIN
(Silene
chalcedonica) 		5 / 10 LEU A  61
PHE A  45
VAL A  48
GLY A  72
LEU A  70
 None
 0.92A 2v3kA-2g5xA:
undetectable		 2v3kA-2g5xA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 2g5x RIBOSOME-INACTIVATIN
G PROTEIN
(Silene
chalcedonica) 		5 / 10 LEU A  20
ALA A 169
LEU A  61
VAL A  48
PHE A  16
 None
 1.13A 2w9gA-2g5xA:
undetectable		 2w9gA-2g5xA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 2g5x RIBOSOME-INACTIVATIN
G PROTEIN
(Silene
chalcedonica) 		5 / 10 LEU A  20
ALA A 169
LEU A  61
VAL A  48
PHE A  16
 None
 1.11A 2w9hA-2g5xA:
undetectable		 2w9hA-2g5xA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 2g5x RIBOSOME-INACTIVATIN
G PROTEIN
(Silene
chalcedonica) 		5 / 11 LEU A  20
ALA A 169
LEU A  61
VAL A  48
PHE A  16
 None
 1.11A 3frbX-2g5xA:
undetectable		 3frbX-2g5xA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 2g5x RIBOSOME-INACTIVATIN
G PROTEIN
(Silene
chalcedonica) 		3 / 3 SER A  14
ASP A  18
ASP A 179
 None
 0.83A 3iv6A-2g5xA:
undetectable		 3iv6A-2g5xA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 2g5x RIBOSOME-INACTIVATIN
G PROTEIN
(Silene
chalcedonica) 		3 / 3 SER A  14
ASP A  18
ASP A 179
 None
 0.86A 3iv6C-2g5xA:
undetectable		 3iv6C-2g5xA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)		 2g5x RIBOSOME-INACTIVATIN
G PROTEIN
(Silene
chalcedonica) 		5 / 10 TYR A 119
ILE A 165
ALA A 169
GLU A 170
ARG A 173
 None
 0.61A 3u6tA-2g5xA:
25.5		 3u6tA-2g5xA:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 2g5x RIBOSOME-INACTIVATIN
G PROTEIN
(Silene
chalcedonica) 		4 / 5 GLY A 218
ILE A 206
LYS A 205
GLN A 209
 None
 1.03A 4ma8C-2g5xA:
undetectable		 4ma8C-2g5xA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_A_VORA590_1
(14-ALPHA STEROL
DEMETHYLASE)		 2g5x RIBOSOME-INACTIVATIN
G PROTEIN
(Silene
chalcedonica) 		4 / 7 PHE A  16
ILE A 165
LEU A  61
PHE A  63
 None
 1.01A 4uymA-2g5xA:
undetectable		 4uymA-2g5xA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)		 2g5x RIBOSOME-INACTIVATIN
G PROTEIN
(Silene
chalcedonica) 		4 / 7 PHE A  16
ILE A 165
LEU A  61
PHE A  63
 None
 0.98A 4uymB-2g5xA:
undetectable		 4uymB-2g5xA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 2g5x RIBOSOME-INACTIVATIN
G PROTEIN
(Silene
chalcedonica) 		3 / 3 GLU A 170
ALA A 171
PHE A 174
 None
 0.61A 4v1fA-2g5xA:
undetectable		 4v1fA-2g5xA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 2g5x RIBOSOME-INACTIVATIN
G PROTEIN
(Silene
chalcedonica) 		3 / 3 GLU A 170
ALA A 171
PHE A 174
 None
 0.58A 4v1fC-2g5xA:
undetectable		 4v1fC-2g5xA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 2g5x RIBOSOME-INACTIVATIN
G PROTEIN
(Silene
chalcedonica) 		6 / 9 PHE A  88
TYR A 119
ILE A 165
ALA A 169
GLU A 170
ARG A 173
 None
 0.56A 4yp2B-2g5xA:
21.9		 4yp2B-2g5xA:
29.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2g5x RIBOSOME-INACTIVATIN
G PROTEIN
(Silene
chalcedonica) 		5 / 10 ALA A 171
ILE A 177
GLY A 136
LEU A 135
ALA A 192
 None
 1.30A 5ajqB-2g5xA:
undetectable		 5ajqB-2g5xA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 2g5x RIBOSOME-INACTIVATIN
G PROTEIN
(Silene
chalcedonica) 		6 / 9 PHE A  88
TYR A 119
ILE A 165
ALA A 169
GLU A 170
ARG A 173
 None
 0.56A 5cf9B-2g5xA:
25.5		 5cf9B-2g5xA:
29.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 2g5x RIBOSOME-INACTIVATIN
G PROTEIN
(Silene
chalcedonica) 		4 / 6 TYR A 119
ILE A 165
GLU A 170
ARG A 173
 None
 0.35A 5z3jA-2g5xA:
25.5		 5z3jA-2g5xA:
29.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA810_0
(GEPHYRIN)		 2g5x RIBOSOME-INACTIVATIN
G PROTEIN
(Silene
chalcedonica) 		3 / 3 LEU A  17
SER A  15
PHE A  16
 None
 0.67A 6fgcA-2g5xA:
undetectable		 6fgcA-2g5xA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NQA_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 2g5x RIBOSOME-INACTIVATIN
G PROTEIN
(Silene
chalcedonica) 		5 / 10 GLY A  72
VAL A 157
GLU A  91
ASN A  86
PHE A 103
 None
 1.24A 6nqaK-2g5xA:
undetectable		 6nqaK-2g5xA:
18.99