SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2g60'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_A_5FWA601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 2g60 ANTI-FLAG M2 FAB
HEAVY CHAIN
(Mus
musculus) 		5 / 12 VAL H 171
VAL H 191
SER H 189
ASN H 209
ASN H 162
 None
 1.44A 2y03A-2g60H:
undetectable		 2y03A-2g60H:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_B_5FWB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 2g60 ANTI-FLAG M2 FAB
HEAVY CHAIN
(Mus
musculus) 		5 / 12 VAL H 171
VAL H 191
SER H 189
ASN H 209
ASN H 162
 None
 1.47A 2y03B-2g60H:
undetectable		 2y03B-2g60H:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NYA_A_JTZA1203_1
(BETA-2 ADRENERGIC
RECEPTOR, LYSOZYME)		 2g60 ANTI-FLAG M2 FAB
HEAVY CHAIN
(Mus
musculus) 		5 / 12 VAL H 171
VAL H 191
SER H 189
ASN H 209
ASN H 162
 None
 1.42A 3nyaA-2g60H:
undetectable		 3nyaA-2g60H:
17.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M7K_H_ACTH302_0
(10H10 HEAVY CHAIN)		 2g60 ANTI-FLAG M2 FAB
HEAVY CHAIN
(Mus
musculus) 		4 / 5 VAL H   2
TYR H  27
ARG H  94
TYR H 102
 None
 0.32A 4m7kH-2g60H:
27.7		 4m7kH-2g60H:
63.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2g60 ANTI-FLAG M2 FAB
HEAVY CHAIN
(Mus
musculus) 		3 / 3 SER H 216
ALA H 211
VAL H 210
 None
 0.68A 4o2bC-2g60H:
undetectable		 4o2bC-2g60H:
19.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MTH_A_ACTA302_0
(ANTIBODY FAB HEAVY
CHAIN)		 2g60 ANTI-FLAG M2 FAB
HEAVY CHAIN
(Mus
musculus) 		5 / 5 SER H 112
ALA H 114
PHE H 148
LEU H 178
ASP H 183
 None
 0.34A 5mthA-2g60H:
28.9		 5mthA-2g60H:
79.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA CHAIN)		 2g60 ANTI-FLAG M2 FAB
HEAVY CHAIN
(Mus
musculus) 		3 / 3 SER H 216
ALA H 211
VAL H 210
 None
 0.49A 5xiwC-2g60H:
undetectable		 5xiwC-2g60H:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 2g60 ANTI-FLAG M2 FAB
HEAVY CHAIN
(Mus
musculus) 		4 / 6 SER H   7
ALA H 214
THR H 116
ALA H  12
 None
 0.99A 6ma6A-2g60H:
undetectable		 6ma6A-2g60H:
16.85