SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2g64'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 2g64 PUTATIVE 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Caenorhabditis
elegans) 		5 / 11 LEU A 122
LEU A  79
MET A 116
LEU A  71
VAL A 125
 None
 1.39A 1ee2A-2g64A:
undetectable		 1ee2A-2g64A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 2g64 PUTATIVE 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Caenorhabditis
elegans) 		4 / 6 MET A  75
VAL A  78
LEU A  79
PHE A  15
 None
 0.97A 1x8vA-2g64A:
undetectable		 1x8vA-2g64A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 2g64 PUTATIVE 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Caenorhabditis
elegans) 		4 / 8 ASP A  88
SER A  99
TYR A  48
HIS A  44
 None
None
None
ZN  A2001 ( 3.3A)
 1.37A 2bteD-2g64A:
undetectable		 2bteD-2g64A:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_A_H4BA1003_1
(HYPOTHETICAL PROTEIN
PH0634)		 2g64 PUTATIVE 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Caenorhabditis
elegans) 		5 / 10 HIS A  19
HIS A  44
HIS A  46
THR A 100
GLU A 102
 ZN  A2001 (-3.3A)
ZN  A2001 ( 3.3A)
ZN  A2001 (-3.3A)
None
None
 0.62A 2dttA-2g64A:
15.6
2dttC-2g64A:
15.4		 2dttA-2g64A:
28.47
2dttC-2g64A:
28.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_A_H4BA1003_1
(HYPOTHETICAL PROTEIN
PH0634)		 2g64 PUTATIVE 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Caenorhabditis
elegans) 		5 / 10 HIS A  19
HIS A  44
HIS A  46
THR A 100
PHE A 135
 ZN  A2001 (-3.3A)
ZN  A2001 ( 3.3A)
ZN  A2001 (-3.3A)
None
None
 1.39A 2dttA-2g64A:
15.6
2dttC-2g64A:
15.4		 2dttA-2g64A:
28.47
2dttC-2g64A:
28.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_A_H4BA1003_1
(HYPOTHETICAL PROTEIN
PH0634)		 2g64 PUTATIVE 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Caenorhabditis
elegans) 		5 / 10 HIS A  44
HIS A  46
THR A 100
GLU A 102
GLU A 129
 ZN  A2001 ( 3.3A)
ZN  A2001 (-3.3A)
None
None
ZN  A2001 (-4.7A)
 0.72A 2dttA-2g64A:
15.6
2dttC-2g64A:
15.4		 2dttA-2g64A:
28.47
2dttC-2g64A:
28.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_D_H4BD1006_1
(HYPOTHETICAL PROTEIN
PH0634)		 2g64 PUTATIVE 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Caenorhabditis
elegans) 		6 / 10 HIS A  19
HIS A  44
HIS A  46
THR A 100
GLU A 102
GLU A 129
 ZN  A2001 (-3.3A)
ZN  A2001 ( 3.3A)
ZN  A2001 (-3.3A)
None
None
ZN  A2001 (-4.7A)
 0.73A 2dttD-2g64A:
15.5
2dttF-2g64A:
15.3		 2dttD-2g64A:
28.47
2dttF-2g64A:
28.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_A_DP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 2g64 PUTATIVE 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 TYR A  48
PHE A  94
TYR A 107
VAL A 104
ILE A 127
 None
 1.17A 3apwA-2g64A:
undetectable		 3apwA-2g64A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA301_0
(THAUMATIN-1)		 2g64 PUTATIVE 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Caenorhabditis
elegans) 		3 / 3 THR A  97
ASN A 103
SER A  99
 None
 0.76A 4tvtA-2g64A:
undetectable		 4tvtA-2g64A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_B_AZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2g64 PUTATIVE 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Caenorhabditis
elegans) 		5 / 11 HIS A  44
HIS A  46
GLU A 129
HIS A  19
LYS A  32
 ZN  A2001 ( 3.3A)
ZN  A2001 (-3.3A)
ZN  A2001 (-4.7A)
ZN  A2001 (-3.3A)
None
 1.28A 4ygfB-2g64A:
undetectable		 4ygfB-2g64A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_E_AZME303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2g64 PUTATIVE 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 HIS A  44
HIS A  46
GLU A 129
HIS A  19
LYS A  32
 ZN  A2001 ( 3.3A)
ZN  A2001 (-3.3A)
ZN  A2001 (-4.7A)
ZN  A2001 (-3.3A)
None
 1.35A 4ygfE-2g64A:
undetectable		 4ygfE-2g64A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 2g64 PUTATIVE 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Caenorhabditis
elegans) 		4 / 7 VAL A  98
THR A 100
LEU A  26
THR A  34
 None
 1.02A 5e4dA-2g64A:
undetectable
5e4dB-2g64A:
undetectable		 5e4dA-2g64A:
18.14
5e4dB-2g64A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 2g64 PUTATIVE 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Caenorhabditis
elegans) 		3 / 3 HIS A  19
HIS A  46
HIS A  44
 ZN  A2001 (-3.3A)
ZN  A2001 (-3.3A)
ZN  A2001 ( 3.3A)
 0.60A 5zrdA-2g64A:
undetectable		 5zrdA-2g64A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 2g64 PUTATIVE 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE
(Caenorhabditis
elegans) 		3 / 3 HIS A  44
HIS A  19
HIS A  46
 ZN  A2001 ( 3.3A)
ZN  A2001 (-3.3A)
ZN  A2001 (-3.3A)
 0.55A 5zrdA-2g64A:
undetectable		 5zrdA-2g64A:
12.88