SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2g6b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 2g6b RAS-RELATED PROTEIN
RAB-26
(Homo
sapiens) 		3 / 3 PHE A 218
LEU A 141
LEU A 175
 None
 0.65A 1mx1E-2g6bA:
undetectable		 1mx1E-2g6bA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 2g6b RAS-RELATED PROTEIN
RAB-26
(Homo
sapiens) 		5 / 12 THR A  96
GLY A  75
GLY A  73
GLY A 122
ASP A 180
 MG  A 301 ( 3.1A)
GNP  A 302 (-3.3A)
GNP  A 302 (-3.6A)
GNP  A 302 (-3.3A)
GNP  A 302 (-3.0A)
 1.01A 2b25A-2g6bA:
2.6		 2b25A-2g6bA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 2g6b RAS-RELATED PROTEIN
RAB-26
(Homo
sapiens) 		5 / 11 LEU A  80
LEU A 115
LEU A 141
MET A 173
ALA A 217
 None
 1.26A 3e22B-2g6bA:
4.3		 3e22B-2g6bA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)		 2g6b RAS-RELATED PROTEIN
RAB-26
(Homo
sapiens) 		5 / 11 LEU A  80
LEU A 115
LEU A 141
MET A 173
ALA A 217
 None
 1.29A 3e22D-2g6bA:
4.0		 3e22D-2g6bA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2g6b RAS-RELATED PROTEIN
RAB-26
(Homo
sapiens) 		3 / 3 GLY A  73
GLY A  75
THR A  77
 GNP  A 302 (-3.6A)
GNP  A 302 (-3.3A)
MG  A 301 ( 3.0A)
 0.45A 3si7B-2g6bA:
undetectable		 3si7B-2g6bA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 2g6b RAS-RELATED PROTEIN
RAB-26
(Homo
sapiens) 		4 / 6 LEU A  80
PHE A 218
ALA A 217
LEU A 143
 None
 0.98A 3t3zD-2g6bA:
undetectable		 3t3zD-2g6bA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_D_CAMD502_0
(CAMPHOR
5-MONOOXYGENASE)		 2g6b RAS-RELATED PROTEIN
RAB-26
(Homo
sapiens) 		4 / 5 PHE A 218
LEU A 143
GLY A  75
VAL A  81
 None
None
GNP  A 302 (-3.3A)
None
 1.02A 3wrkD-2g6bA:
undetectable		 3wrkD-2g6bA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 2g6b RAS-RELATED PROTEIN
RAB-26
(Homo
sapiens) 		5 / 12 ALA A 217
LEU A 143
LEU A 175
ARG A 189
GLY A  75
 None
None
None
None
GNP  A 302 (-3.3A)
 1.02A 4dm8B-2g6bA:
undetectable		 4dm8B-2g6bA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 2g6b RAS-RELATED PROTEIN
RAB-26
(Homo
sapiens) 		5 / 12 LEU A 216
ALA A 217
LEU A 143
LEU A 175
GLY A  75
 None
None
None
None
GNP  A 302 (-3.3A)
 0.69A 4dm8B-2g6bA:
undetectable		 4dm8B-2g6bA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 2g6b RAS-RELATED PROTEIN
RAB-26
(Homo
sapiens) 		3 / 3 PHE A 101
ASP A 119
ARG A 102
 None
MG  A 301 ( 3.9A)
None
 0.89A 4eahF-2g6bA:
2.0		 4eahF-2g6bA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 2g6b RAS-RELATED PROTEIN
RAB-26
(Homo
sapiens) 		3 / 3 PHE A 101
ASP A 119
ARG A 102
 None
MG  A 301 ( 3.9A)
None
 0.88A 4eahG-2g6bA:
1.9		 4eahG-2g6bA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 2g6b RAS-RELATED PROTEIN
RAB-26
(Homo
sapiens) 		4 / 4 VAL A 187
LEU A 195
ASN A 148
ASP A 145
 None
 1.17A 5vcyA-2g6bA:
undetectable		 5vcyA-2g6bA:
22.19