SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2g6z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CO4_A_GCSA401_1
(CHITINASE)		 2g6z DUAL SPECIFICITY
PROTEIN PHOSPHATASE
5
(Homo
sapiens) 		3 / 3 GLU A 264
HIS A 193
HIS A 262
 SO4  A 502 ( 3.9A)
None
None
 0.87A 3co4A-2g6zA:
undetectable		 3co4A-2g6zA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQL_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2g6z DUAL SPECIFICITY
PROTEIN PHOSPHATASE
5
(Homo
sapiens) 		4 / 8 GLU A 264
SER A 263
VAL A 211
TRP A 227
 SO4  A 502 ( 3.9A)
SO4  A 501 (-2.6A)
None
None
 1.34A 3rqlA-2g6zA:
undetectable
3rqlB-2g6zA:
undetectable		 3rqlA-2g6zA:
19.48
3rqlB-2g6zA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2g6z DUAL SPECIFICITY
PROTEIN PHOSPHATASE
5
(Homo
sapiens) 		4 / 4 ASN A 303
VAL A 230
THR A 272
ILE A 273
 None
 1.25A 4retA-2g6zA:
4.1		 4retA-2g6zA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2g6z DUAL SPECIFICITY
PROTEIN PHOSPHATASE
5
(Homo
sapiens) 		4 / 4 ASN A 303
VAL A 230
THR A 272
ILE A 273
 None
 1.25A 4retC-2g6zA:
4.1		 4retC-2g6zA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2g6z DUAL SPECIFICITY
PROTEIN PHOSPHATASE
5
(Homo
sapiens) 		4 / 8 GLU A 264
SER A 263
VAL A 211
TRP A 227
 SO4  A 502 ( 3.9A)
SO4  A 501 (-2.6A)
None
None
 1.32A 4v3yA-2g6zA:
undetectable
4v3yB-2g6zA:
undetectable		 4v3yA-2g6zA:
19.48
4v3yB-2g6zA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2g6z DUAL SPECIFICITY
PROTEIN PHOSPHATASE
5
(Homo
sapiens) 		4 / 5 SER A 190
ALA A 265
HIS A 193
MET A 299
 None
SO4  A 501 (-3.4A)
None
None
 1.41A 5dzkb-2g6zA:
undetectable
5dzkp-2g6zA:
undetectable		 5dzkb-2g6zA:
23.31
5dzkp-2g6zA:
1.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2g6z DUAL SPECIFICITY
PROTEIN PHOSPHATASE
5
(Homo
sapiens) 		4 / 5 SER A 190
ALA A 265
HIS A 193
MET A 299
 None
SO4  A 501 (-3.4A)
None
None
 1.41A 5dzkc-2g6zA:
undetectable
5dzkq-2g6zA:
undetectable		 5dzkc-2g6zA:
23.31
5dzkq-2g6zA:
1.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2g6z DUAL SPECIFICITY
PROTEIN PHOSPHATASE
5
(Homo
sapiens) 		4 / 5 SER A 190
ALA A 265
HIS A 193
MET A 299
 None
SO4  A 501 (-3.4A)
None
None
 1.41A 5dzkf-2g6zA:
undetectable
5dzkt-2g6zA:
undetectable		 5dzkf-2g6zA:
23.31
5dzkt-2g6zA:
1.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2g6z DUAL SPECIFICITY
PROTEIN PHOSPHATASE
5
(Homo
sapiens) 		3 / 3 LYS A 280
LEU A 186
ILE A 273
 None
 0.75A 5kc0A-2g6zA:
undetectable		 5kc0A-2g6zA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2g6z DUAL SPECIFICITY
PROTEIN PHOSPHATASE
5
(Homo
sapiens) 		3 / 3 LYS A 280
LEU A 186
ILE A 273
 None
 0.82A 5kc4A-2g6zA:
undetectable		 5kc4A-2g6zA:
23.29