SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2g76'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 2g76 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Homo
sapiens) 		4 / 8 ASN A 232
LEU A 244
ALA A 247
LEU A 248
 None
 1.06A 1hwiB-2g76A:
undetectable		 1hwiB-2g76A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 2g76 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Homo
sapiens) 		4 / 8 ASN A 232
LEU A 244
ALA A 247
LEU A 248
 None
 1.06A 1hwiC-2g76A:
undetectable		 1hwiC-2g76A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 2g76 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Homo
sapiens) 		4 / 8 ARG A 162
LEU A 116
VAL A 231
VAL A 159
 None
 0.97A 2bdmA-2g76A:
undetectable		 2bdmA-2g76A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 2g76 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Homo
sapiens) 		4 / 7 LEU A 244
LEU A 216
PHE A 221
LEU A 248
 None
 0.95A 2vq5B-2g76A:
undetectable		 2vq5B-2g76A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		 2g76 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Homo
sapiens) 		5 / 12 LEU A  50
GLY A  49
LEU A   9
PHE A 302
LEU A  14
 None
 0.86A 3gwvA-2g76A:
undetectable		 3gwvA-2g76A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 2g76 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Homo
sapiens) 		4 / 6 ALA A  75
ILE A  51
LEU A  14
GLU A 297
 None
 0.82A 3r9sA-2g76A:
undetectable		 3r9sA-2g76A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 2g76 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Homo
sapiens) 		5 / 12 LEU A 216
ILE A 195
ILE A 238
ALA A 234
VAL A 187
 None
None
None
NAD  A 501 (-3.8A)
None
 1.20A 3vw1D-2g76A:
undetectable		 3vw1D-2g76A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 2g76 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Homo
sapiens) 		4 / 7 ILE A  21
LEU A  22
PHE A 302
GLY A  73
 None
 0.96A 4hajA-2g76A:
undetectable		 4hajA-2g76A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB6_A_DXCA75_0
(PPCA)		 2g76 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Homo
sapiens) 		4 / 8 ILE A  21
LEU A  22
PHE A 302
GLY A  73
 None
 0.89A 4hb6A-2g76A:
undetectable		 4hb6A-2g76A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 2g76 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Homo
sapiens) 		4 / 7 ILE A  21
LEU A  22
PHE A 302
GLY A  73
 None
 0.88A 4hbfA-2g76A:
undetectable		 4hbfA-2g76A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 2g76 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Homo
sapiens) 		4 / 6 ASP A  80
ARG A 235
GLY A 237
HIS A 282
 None
MLT  A 503 ( 2.8A)
None
MLT  A 503 ( 3.9A)
 0.91A 4oltA-2g76A:
undetectable		 4oltA-2g76A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 2g76 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Homo
sapiens) 		4 / 6 ASP A  80
ARG A 235
GLY A 237
HIS A 282
 None
MLT  A 503 ( 2.8A)
None
MLT  A 503 ( 3.9A)
 0.92A 4oltB-2g76A:
undetectable		 4oltB-2g76A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		 2g76 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Homo
sapiens) 		5 / 12 LEU A 216
ASN A 217
GLY A 214
LEU A 150
GLN A 223
 None
 1.36A 4p6xA-2g76A:
undetectable		 4p6xA-2g76A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		 2g76 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Homo
sapiens) 		5 / 12 LEU A 216
ASN A 217
GLY A 214
LEU A 150
GLN A 223
 None
 1.39A 4p6xE-2g76A:
undetectable		 4p6xE-2g76A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		 2g76 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Homo
sapiens) 		5 / 12 LEU A 216
ASN A 217
GLY A 214
LEU A 150
GLN A 223
 None
 1.40A 4p6xI-2g76A:
undetectable		 4p6xI-2g76A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 2g76 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Homo
sapiens) 		4 / 8 THR A  97
SER A  54
ALA A 285
SER A 286
 None
MLT  A 503 (-2.7A)
MLT  A 503 ( 3.3A)
None
 1.08A 5l5fY-2g76A:
undetectable
5l5fZ-2g76A:
undetectable		 5l5fY-2g76A:
23.66
5l5fZ-2g76A:
22.78