SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2g7c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 2g7c TOXIN A
(Clostridioides
difficile) 		4 / 8 ALA A 123
GLY A 144
ILE A 114
VAL A  76
 None
 0.78A 1d4sB-2g7cA:
undetectable		 1d4sB-2g7cA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2g7c TOXIN A
(Clostridioides
difficile) 		4 / 7 ILE A 165
GLY A 189
ASN A 181
ASN A 186
 None
 0.89A 1oniG-2g7cA:
undetectable
1oniI-2g7cA:
undetectable		 1oniG-2g7cA:
19.44
1oniI-2g7cA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2g7c TOXIN A
(Clostridioides
difficile) 		5 / 12 PHE A 241
MET A 229
THR A 216
VAL A 215
ILE A 243
 None
 1.39A 3elzA-2g7cA:
undetectable		 3elzA-2g7cA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)		 2g7c TOXIN A
(Clostridioides
difficile) 		5 / 10 GLY A 126
ILE A 187
PHE A 168
PHE A 158
GLY A 161
 None
 1.44A 3ko0R-2g7cA:
undetectable
3ko0T-2g7cA:
undetectable		 3ko0R-2g7cA:
15.32
3ko0T-2g7cA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2g7c TOXIN A
(Clostridioides
difficile) 		5 / 11 VAL A 167
ILE A 205
ALA A 214
THR A 216
ALA A 235
 None
GOL  A 501 (-3.9A)
None
None
None
 1.08A 3mdtB-2g7cA:
undetectable		 3mdtB-2g7cA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2g7c TOXIN A
(Clostridioides
difficile) 		5 / 12 GLY A  34
THR A  33
PHE A  64
ILE A  59
PHE A  66
 None
 1.23A 4zvmA-2g7cA:
undetectable
4zvmB-2g7cA:
undetectable		 4zvmA-2g7cA:
22.26
4zvmB-2g7cA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2g7c TOXIN A
(Clostridioides
difficile) 		5 / 12 GLY A 126
THR A 125
PHE A 156
ILE A 151
PHE A 158
 None
 1.20A 4zvmA-2g7cA:
undetectable
4zvmB-2g7cA:
undetectable		 4zvmA-2g7cA:
22.26
4zvmB-2g7cA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2g7c TOXIN A
(Clostridioides
difficile) 		4 / 7 LYS A  21
ASP A  69
ILE A  71
TYR A  43
 None
 1.23A 5a06B-2g7cA:
undetectable		 5a06B-2g7cA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 2g7c TOXIN A
(Clostridioides
difficile) 		5 / 12 ALA A 180
ASP A 188
GLY A 166
LEU A 202
LEU A 201
 None
 1.02A 5wwsA-2g7cA:
undetectable		 5wwsA-2g7cA:
18.70