SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2g7l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 2g7l TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 10 ALA A  28
LEU A  66
ARG A  21
HIS A 107
LEU A  37
 None
 1.45A 1a52A-2g7lA:
undetectable		 1a52A-2g7lA:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)		 2g7l TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 10 ALA A  28
LEU A  66
ARG A  21
HIS A 107
LEU A  37
 None
 1.46A 1a52B-2g7lA:
undetectable		 1a52B-2g7lA:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_B_ESTB2_1
(ESTROGEN RECEPTOR)		 2g7l TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 10 ALA A  28
LEU A  66
ARG A  21
HIS A 107
LEU A  37
 None
 1.47A 1pcgB-2g7lA:
undetectable		 1pcgB-2g7lA:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 2g7l TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 10 ALA A  28
LEU A  66
ARG A  21
HIS A 107
LEU A  37
 None
 1.49A 1qkuB-2g7lA:
undetectable		 1qkuB-2g7lA:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 2g7l TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 10 ALA A  28
LEU A  66
ARG A  21
HIS A 107
LEU A  37
 None
 1.48A 1qkuC-2g7lA:
undetectable		 1qkuC-2g7lA:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 2g7l TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 11 LEU A  97
ALA A 158
ALA A 156
VAL A  96
LEU A  80
 None
 1.06A 1rlbF-2g7lA:
undetectable		 1rlbF-2g7lA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2g7l TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 12 LEU A 135
LEU A 127
ILE A 221
LEU A 104
VAL A 103
 None
 1.09A 2pnjA-2g7lA:
undetectable		 2pnjA-2g7lA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_B_ESTB600_1
(ESTROGEN RECEPTOR)		 2g7l TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 10 ALA A  28
LEU A  66
ARG A  21
HIS A 107
LEU A  37
 None
 1.49A 3uudB-2g7lA:
0.0		 3uudB-2g7lA:
26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 2g7l TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		3 / 3 VAL A 128
LEU A 132
VAL A 149
 None
 0.46A 4wq4A-2g7lA:
undetectable		 4wq4A-2g7lA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 2g7l TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 9 ALA A  28
LEU A  66
ARG A  21
HIS A 107
LEU A  37
 None
 1.45A 5dx3B-2g7lA:
2.6		 5dx3B-2g7lA:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 2g7l TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 10 ALA A  28
LEU A  66
ARG A  21
HIS A 107
LEU A  37
 None
 1.46A 5dxeB-2g7lA:
undetectable		 5dxeB-2g7lA:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_B_ESTB601_1
(ESTROGEN RECEPTOR)		 2g7l TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 11 ALA A  28
LEU A  66
ARG A  21
HIS A 107
LEU A  37
 None
 1.48A 5hyrB-2g7lA:
undetectable		 5hyrB-2g7lA:
26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2g7l TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 5 ARG A  44
MET A  42
THR A  41
LEU A  66
 None
 1.37A 5wauJ-2g7lA:
undetectable		 5wauJ-2g7lA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 2g7l TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		3 / 3 LEU A  97
VAL A 149
ASP A 150
 None
 0.63A 5x23A-2g7lA:
undetectable		 5x23A-2g7lA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 2g7l TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 12 GLY A 148
PRO A 141
GLY A 142
LEU A 217
ASP A 155
 None
 1.13A 5yn6A-2g7lA:
undetectable		 5yn6A-2g7lA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 2g7l TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 12 GLY A 148
PRO A 141
GLY A 142
LEU A 217
ASP A 155
 None
 1.11A 5yniA-2g7lA:
undetectable		 5yniA-2g7lA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 2g7l TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 12 GLY A 148
PRO A 141
GLY A 142
LEU A 217
ASP A 155
 None
 1.08A 5ynmA-2g7lA:
undetectable		 5ynmA-2g7lA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 2g7l TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 10 ALA A  28
LEU A  66
ARG A  21
HIS A 107
LEU A  37
 None
 1.46A 6cbzB-2g7lA:
undetectable		 6cbzB-2g7lA:
16.74