SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2g7z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 2g7z CONSERVED
HYPOTHETICAL PROTEIN
SPY1493
(Streptococcus
pyogenes) 		4 / 8 LEU A 213
VAL A 189
TYR A 158
GLY A 160
 None
 0.83A 1jlbA-2g7zA:
undetectable		 1jlbA-2g7zA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2g7z CONSERVED
HYPOTHETICAL PROTEIN
SPY1493
(Streptococcus
pyogenes) 		4 / 7 LEU A 213
VAL A 189
TYR A 158
GLY A 160
 None
 0.85A 1lweA-2g7zA:
2.7		 1lweA-2g7zA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 2g7z CONSERVED
HYPOTHETICAL PROTEIN
SPY1493
(Streptococcus
pyogenes) 		4 / 8 ARG A 245
LEU A 213
VAL A 276
VAL A 256
 None
 0.81A 2bdmA-2g7zA:
undetectable		 2bdmA-2g7zA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 2g7z CONSERVED
HYPOTHETICAL PROTEIN
SPY1493
(Streptococcus
pyogenes) 		4 / 6 THR A  25
ILE A  85
LEU A  77
THR A  73
 None
 0.88A 3deuB-2g7zA:
undetectable		 3deuB-2g7zA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 2g7z CONSERVED
HYPOTHETICAL PROTEIN
SPY1493
(Streptococcus
pyogenes) 		4 / 5 GLN A 122
THR A 259
LEU A 192
LEU A 157
 None
HXA  A9136 ( 3.7A)
None
None
 0.98A 4lvcB-2g7zA:
undetectable		 4lvcB-2g7zA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2g7z CONSERVED
HYPOTHETICAL PROTEIN
SPY1493
(Streptococcus
pyogenes) 		3 / 3 ILE A 263
ASP A  40
ARG A 172
 HXA  A9136 (-4.2A)
None
TRS  A5081 ( 3.6A)
 0.75A 4pstA-2g7zA:
undetectable		 4pstA-2g7zA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2g7z CONSERVED
HYPOTHETICAL PROTEIN
SPY1493
(Streptococcus
pyogenes) 		3 / 3 THR A 267
HIS A  89
LEU A  29
 HXA  A9136 ( 4.2A)
None
None
 0.80A 5axdA-2g7zA:
2.1		 5axdA-2g7zA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2g7z CONSERVED
HYPOTHETICAL PROTEIN
SPY1493
(Streptococcus
pyogenes) 		3 / 3 THR A 267
HIS A  89
LEU A  29
 HXA  A9136 ( 4.2A)
None
None
 0.84A 5axdC-2g7zA:
2.1		 5axdC-2g7zA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 2g7z CONSERVED
HYPOTHETICAL PROTEIN
SPY1493
(Streptococcus
pyogenes) 		5 / 12 GLY A 160
VAL A 188
ILE A 159
GLY A 170
GLY A 171
 None
None
HXA  A9136 ( 4.3A)
GOL  A2647 (-2.9A)
None
 0.95A 5koxA-2g7zA:
undetectable		 5koxA-2g7zA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2g7z CONSERVED
HYPOTHETICAL PROTEIN
SPY1493
(Streptococcus
pyogenes) 		4 / 4 GLN A 122
THR A 259
LEU A 192
LEU A 157
 None
HXA  A9136 ( 3.7A)
None
None
 0.98A 5m5kB-2g7zA:
undetectable		 5m5kB-2g7zA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 2g7z CONSERVED
HYPOTHETICAL PROTEIN
SPY1493
(Streptococcus
pyogenes) 		4 / 7 ASP A 214
THR A 210
LEU A 213
TYR A 249
 None
 0.96A 5ov9A-2g7zA:
2.0		 5ov9A-2g7zA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 2g7z CONSERVED
HYPOTHETICAL PROTEIN
SPY1493
(Streptococcus
pyogenes) 		4 / 8 ASP A 214
THR A 210
LEU A 213
TYR A 249
 None
 0.96A 5ov9B-2g7zA:
1.6		 5ov9B-2g7zA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_A_SALA503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 2g7z CONSERVED
HYPOTHETICAL PROTEIN
SPY1493
(Streptococcus
pyogenes) 		4 / 7 THR A 259
PHE A  49
MET A  53
THR A  62
 HXA  A9136 ( 3.7A)
None
None
GOL  A2647 ( 3.3A)
 1.42A 5u6mA-2g7zA:
3.1		 5u6mA-2g7zA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_B_SALB503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 2g7z CONSERVED
HYPOTHETICAL PROTEIN
SPY1493
(Streptococcus
pyogenes) 		4 / 7 THR A 259
PHE A  49
MET A  53
THR A  62
 HXA  A9136 ( 3.7A)
None
None
GOL  A2647 ( 3.3A)
 1.44A 5u6mB-2g7zA:
2.2		 5u6mB-2g7zA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 2g7z CONSERVED
HYPOTHETICAL PROTEIN
SPY1493
(Streptococcus
pyogenes) 		3 / 3 GLY A   2
ASP A  84
ILE A 144
 None
ZN  A6003 (-2.3A)
None
 0.53A 6dgxB-2g7zA:
undetectable		 6dgxB-2g7zA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 2g7z CONSERVED
HYPOTHETICAL PROTEIN
SPY1493
(Streptococcus
pyogenes) 		4 / 5 ILE A 263
GLN A 122
THR A 259
LEU A 192
 HXA  A9136 (-4.2A)
None
HXA  A9136 ( 3.7A)
None
 0.97A 6f3mD-2g7zA:
undetectable		 6f3mD-2g7zA:
22.27