SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2g85'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2g85 CHORISMATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 367
LEU A 155
ALA A 225
ALA A 227
LEU A 234
 None
 1.33A 1iiuA-2g85A:
undetectable		 1iiuA-2g85A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2g85 CHORISMATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 367
LEU A 155
ALA A 225
ALA A 227
LEU A 234
 None
 1.35A 1kt5A-2g85A:
undetectable		 1kt5A-2g85A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_2
(PROTEASE)		 2g85 CHORISMATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 11 GLY A 351
ALA A 350
ILE A 317
GLY A 220
ILE A 258
 None
 0.84A 1n49B-2g85A:
undetectable		 1n49B-2g85A:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_1
(PROTEASE)		 2g85 CHORISMATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 11 GLY A 351
ALA A 350
ILE A 317
GLY A 220
ILE A 258
 None
 0.85A 1n49C-2g85A:
undetectable		 1n49C-2g85A:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2g85 CHORISMATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 159
LEU A 155
ALA A 153
LEU A 367
ILE A 382
 None
 0.99A 1s9pD-2g85A:
undetectable		 1s9pD-2g85A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 2g85 CHORISMATE SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 128
ARG A 130
ASP A 117
 None
 0.94A 1vptA-2g85A:
undetectable		 1vptA-2g85A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 2g85 CHORISMATE SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 159
LEU A 244
PHE A 370
 None
 0.73A 2pgrA-2g85A:
undetectable		 2pgrA-2g85A:
19.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QHF_A_ACTA502_0
(CHORISMATE SYNTHASE)		 2g85 CHORISMATE SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 GLY A 240
ASP A 241
SER A 246
 None
 0.32A 2qhfA-2g85A:
26.3		 2qhfA-2g85A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QHF_A_ACTA503_0
(CHORISMATE SYNTHASE)		 2g85 CHORISMATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 5 GLN A  36
THR A 149
ARG A 152
ALA A 151
 None
 1.35A 2qhfA-2g85A:
59.1		 2qhfA-2g85A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QHF_A_ACTA503_0
(CHORISMATE SYNTHASE)		 2g85 CHORISMATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 5 GLN A  36
THR A 149
ARG A 152
ALA A 153
ARG A 156
 None
 0.29A 2qhfA-2g85A:
59.1		 2qhfA-2g85A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QHF_A_ACTA507_0
(CHORISMATE SYNTHASE)		 2g85 CHORISMATE SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 LEU A  15
ASN A  79
ARG A 139
 None
 0.21A 2qhfA-2g85A:
59.1		 2qhfA-2g85A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 2g85 CHORISMATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 5 LEU A 108
ARG A 110
ASP A 117
ALA A 129
ILE A 338
 None
 1.14A 2qhfA-2g85A:
59.1		 2qhfA-2g85A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 2g85 CHORISMATE SYNTHASE
(Mycobacterium
tuberculosis) 		7 / 11 ALA A 138
THR A 141
ILE A 317
ARG A 341
ALA A 346
ALA A 349
VAL A 353
 None
 1.31A 2qhfA-2g85A:
59.1		 2qhfA-2g85A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 2g85 CHORISMATE SYNTHASE
(Mycobacterium
tuberculosis) 		10 / 11 ARG A  40
ALA A 138
THR A 141
ILE A 255
MET A 314
ILE A 317
ARG A 341
ALA A 346
ALA A 350
VAL A 353
 None
 0.48A 2qhfA-2g85A:
59.1		 2qhfA-2g85A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 2g85 CHORISMATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 11 ILE A 258
ILE A 317
ARG A 341
ALA A 346
ALA A 350
 None
 0.85A 2qhfA-2g85A:
59.1		 2qhfA-2g85A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2g85 CHORISMATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 6 ILE A 382
PHE A 154
GLY A 371
GLY A 372
 None
 0.84A 2qx6A-2g85A:
undetectable
2qx6B-2g85A:
undetectable		 2qx6A-2g85A:
21.16
2qx6B-2g85A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 2g85 CHORISMATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 220
GLY A 171
ILE A 209
ALA A 257
VAL A 344
 None
 0.97A 2yqzA-2g85A:
undetectable		 2yqzA-2g85A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 2g85 CHORISMATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 4 VAL A 352
ARG A 139
ILE A 317
THR A 356
 None
 1.05A 3cl9A-2g85A:
undetectable		 3cl9A-2g85A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2g85 CHORISMATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A   2
LEU A 375
VAL A  26
VAL A  23
ILE A 382
 None
 1.12A 3gwxB-2g85A:
undetectable		 3gwxB-2g85A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA314_0
(UNCHARACTERIZED
PROTEIN)		 2g85 CHORISMATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 THR A 356
LEU A 360
LEU A 375
ILE A  63
ILE A  75
 None
 1.01A 3ijdA-2g85A:
undetectable		 3ijdA-2g85A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2g85 CHORISMATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 6 VAL A  57
LEU A 360
ILE A   5
ALA A 146
LEU A  37
 None
 1.36A 3kk6B-2g85A:
undetectable		 3kk6B-2g85A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2g85 CHORISMATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 360
VAL A  26
ILE A  77
ILE A  75
VAL A  19
 None
 0.96A 3w68D-2g85A:
undetectable		 3w68D-2g85A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2g85 CHORISMATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 8 ILE A 263
GLY A 264
VAL A 252
ARG A 152
 None
 0.88A 4acbB-2g85A:
undetectable
4acbC-2g85A:
undetectable		 4acbB-2g85A:
21.51
4acbC-2g85A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_A_ACTA202_0
(NITROGEN REGULATORY
PROTEIN P-II)		 2g85 CHORISMATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 4 VAL A 145
GLY A 148
ARG A 152
VAL A 352
 None
 1.02A 5d4nA-2g85A:
0.0
5d4nB-2g85A:
0.0		 5d4nA-2g85A:
14.70
5d4nB-2g85A:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)		 2g85 CHORISMATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 5 VAL A 352
VAL A 145
GLY A 148
ARG A 152
 None
 0.96A 5d4nA-2g85A:
0.7
5d4nC-2g85A:
undetectable		 5d4nA-2g85A:
14.70
5d4nC-2g85A:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_A_NIZA808_1
(CATALASE-PEROXIDASE)		 2g85 CHORISMATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 8 ARG A 139
GLU A 134
GLY A   8
LEU A  15
 None
 0.88A 5sxqA-2g85A:
undetectable		 5sxqA-2g85A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 2g85 CHORISMATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 8 ARG A 139
GLU A 134
GLY A   8
LEU A  15
 None
 0.87A 5sxqB-2g85A:
undetectable		 5sxqB-2g85A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_A_NIZA807_1
(CATALASE-PEROXIDASE)		 2g85 CHORISMATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 8 ARG A 139
GLU A 134
GLY A   8
LEU A  15
 None
 0.83A 5sxtA-2g85A:
undetectable		 5sxtA-2g85A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)		 2g85 CHORISMATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 8 ARG A 139
GLU A 134
GLY A   8
LEU A  15
 None
 0.85A 5sxtB-2g85A:
undetectable		 5sxtB-2g85A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 2g85 CHORISMATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 8 ARG A 139
GLU A 134
GLY A   8
LEU A  15
 None
 0.88A 5syjA-2g85A:
undetectable		 5syjA-2g85A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 2g85 CHORISMATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 8 ARG A 139
GLU A 134
GLY A   8
LEU A  15
 None
 0.88A 5syjB-2g85A:
undetectable		 5syjB-2g85A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 2g85 CHORISMATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  73
GLY A  62
ILE A  33
VAL A  57
ILE A  75
 None
 1.01A 6emuA-2g85A:
undetectable		 6emuA-2g85A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 2g85 CHORISMATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  73
GLY A  62
ILE A  33
VAL A  57
ILE A  75
 None
 0.98A 6emuB-2g85A:
undetectable		 6emuB-2g85A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2g85 CHORISMATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 6 ILE A  33
ALA A 153
ARG A 152
ASP A 185
 None
 1.10A 6hu9m-2g85A:
undetectable
6hu9q-2g85A:
undetectable		 6hu9m-2g85A:
23.03
6hu9q-2g85A:
16.40