SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2g8l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2g8l 287AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 9 LEU A 222
ILE A  49
ALA A  53
SER A  55
LEU A  56
 None
None
None
None
EDO  A 289 ( 4.2A)
 1.13A 1eqgA-2g8lA:
undetectable		 1eqgA-2g8lA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2g8l 287AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 11 LEU A 222
ILE A  49
ALA A  53
SER A  55
LEU A  56
 None
None
None
None
EDO  A 289 ( 4.2A)
 1.13A 1eqgB-2g8lA:
undetectable		 1eqgB-2g8lA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_A_BEZA1501_0
(ANTHRANILATE
SYNTHASE)		 2g8l 287AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 11 ILE A 188
GLY A 186
THR A 193
GLU A 185
GLY A 212
 None
 1.43A 1i7qA-2g8lA:
undetectable		 1i7qA-2g8lA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_C_BEZC1502_0
(ANTHRANILATE
SYNTHASE)		 2g8l 287AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 10 ILE A 188
GLY A 186
THR A 193
GLU A 185
GLY A 212
 None
 1.45A 1i7qC-2g8lA:
undetectable		 1i7qC-2g8lA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 2g8l 287AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 ASP A 156
ASP A 164
LYS A 184
 UNL  A 288 (-3.1A)
None
None
 1.12A 1lqtB-2g8lA:
2.6		 1lqtB-2g8lA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1430_0
(FPRA)		 2g8l 287AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 ASP A 156
ASP A 164
LYS A 184
 UNL  A 288 (-3.1A)
None
None
 1.13A 1lquB-2g8lA:
undetectable		 1lquB-2g8lA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2g8l 287AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 11 ILE A 105
VAL A 101
ALA A 100
PHE A  97
ILE A 166
 None
 1.10A 1uduA-2g8lA:
undetectable		 1uduA-2g8lA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 2g8l 287AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 PHE A 227
GLY A 212
ILE A 215
GLU A 195
ALA A 182
 None
 1.32A 1vq1A-2g8lA:
5.5		 1vq1A-2g8lA:
26.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)		 2g8l 287AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 LEU A  93
LEU A 129
MET A 128
ILE A 110
GLY A 107
 None
 1.28A 2j7xA-2g8lA:
undetectable		 2j7xA-2g8lA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2g8l 287AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		6 / 12 ALA A 192
VAL A 179
ILE A 171
LEU A 167
THR A 155
ALA A 165
 None
 1.43A 3cs9C-2g8lA:
undetectable		 3cs9C-2g8lA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_2
(FIV PROTEASE)		 2g8l 287AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 10 LEU A 197
ALA A 165
ILE A 238
VAL A 208
LEU A 202
 None
 1.09A 3ogpB-2g8lA:
undetectable		 3ogpB-2g8lA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 2g8l 287AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 ASP A 156
GLU A 246
SER A  78
 UNL  A 288 (-3.1A)
None
None
 0.81A 3p2kA-2g8lA:
3.6		 3p2kA-2g8lA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 2g8l 287AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 LEU A  93
LEU A 129
MET A 128
ILE A 110
GLY A 107
 None
 1.26A 4j26A-2g8lA:
undetectable		 4j26A-2g8lA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 2g8l 287AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ILE A 110
ALA A  82
LEU A  95
LEU A 129
ILE A 106
 None
 1.13A 4km2A-2g8lA:
undetectable		 4km2A-2g8lA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 2g8l 287AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 10 LEU A 167
CYH A 280
LEU A 259
ALA A 104
LEU A 133
 None
 1.13A 4p65A-2g8lA:
undetectable
4p65B-2g8lA:
undetectable
4p65F-2g8lA:
undetectable
4p65H-2g8lA:
undetectable		 4p65A-2g8lA:
4.42
4p65B-2g8lA:
7.17
4p65F-2g8lA:
7.17
4p65H-2g8lA:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 2g8l 287AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 11 LEU A 167
CYH A 280
LEU A 259
ALA A 104
LEU A 133
 None
 1.12A 4p65C-2g8lA:
undetectable
4p65D-2g8lA:
undetectable
4p65J-2g8lA:
undetectable
4p65L-2g8lA:
undetectable		 4p65C-2g8lA:
4.42
4p65D-2g8lA:
7.17
4p65J-2g8lA:
7.17
4p65L-2g8lA:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 2g8l 287AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 11 LEU A 133
LEU A 167
CYH A 280
LEU A 259
ALA A 104
 None
 1.15A 4p65B-2g8lA:
undetectable
4p65D-2g8lA:
undetectable
4p65G-2g8lA:
undetectable
4p65H-2g8lA:
undetectable		 4p65B-2g8lA:
7.17
4p65D-2g8lA:
7.17
4p65G-2g8lA:
4.42
4p65H-2g8lA:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 2g8l 287AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 LEU A 133
LEU A 167
CYH A 280
LEU A 259
ALA A 104
 None
 1.05A 4p65F-2g8lA:
undetectable
4p65H-2g8lA:
undetectable
4p65K-2g8lA:
undetectable
4p65L-2g8lA:
undetectable		 4p65F-2g8lA:
7.17
4p65H-2g8lA:
7.17
4p65K-2g8lA:
4.42
4p65L-2g8lA:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 2g8l 287AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 ASN A 190
PHE A 112
TYR A 162
 None
 0.74A 4u15A-2g8lA:
undetectable		 4u15A-2g8lA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2g8l 287AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 10 ALA A 165
ILE A 166
GLY A 159
ALA A  86
ASP A  87
 None
 1.07A 5ajqB-2g8lA:
undetectable		 5ajqB-2g8lA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2g8l 287AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		4 / 5 ILE A 171
GLY A 206
ILE A 151
LEU A 205
 None
 0.85A 5dzkB-2g8lA:
undetectable
5dzkI-2g8lA:
undetectable
5dzkW-2g8lA:
undetectable		 5dzkB-2g8lA:
21.78
5dzkI-2g8lA:
18.60
5dzkW-2g8lA:
0.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 2g8l 287AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		4 / 5 ILE A 171
GLY A 206
ILE A 151
LEU A 205
 None
 0.83A 5dzki-2g8lA:
undetectable
5dzkj-2g8lA:
undetectable
5dzkx-2g8lA:
undetectable		 5dzki-2g8lA:
18.60
5dzkj-2g8lA:
18.60
5dzkx-2g8lA:
0.67